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Protein: STT4
Organism: Saccharomyces cerevisiae
Length: 1900 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STT4.

Description E-value Query
Range		 Subject
Range
PI4KA_RAT - Phosphatidylinositol 4-kinase alpha OS=Rattus norvegicus GN=Pi4ka PE=1 SV=1
 0.0 [325..1900] [368..2041]
STT4_SCHPO - Phosphatidylinositol 4-kinase stt4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=stt4 PE...
SPBC577.06c - phosphatidylinositol kinase
 0.0 [507..1900] [447..1877]
PI4KA_BOVIN - Phosphatidylinositol 4-kinase alpha OS=Bos taurus GN=PI4KA PE=2 SV=1
 0.0 [325..1900] [368..2043]
PI4KA - phosphatidylinositol 4-kinase, catalytic, alpha
 0.0 [326..1900] [369..2044]
gi|5430764, gi|2... - gi|5430764|gb|AAD43164.1|AC007504_19 Putative Phosphatidylinositol 4-kinase PI4K [Arabidopsis thalia...
 0.0 [526..1898] [509..2049]
STT4_YEAST - Phosphatidylinositol 4-kinase STT4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STT4 ...
STT4 - Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for norma...
 0.0 [1..1900] [1..1900]
gi|6691825 - gi|6691825|emb|CAB65858.1| EG:BACR7C10.2 [Drosophila melanogaster]
 0.0 [327..1290] [458..1425]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [548..1900] [2..1466]

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Predicted Domain #1
Region A:
Residues: [1-505] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFTRGLKAS SSLRAKAIGR LTKLSTGAPN DQNSNGTTLD LITHTLPIFY STNTSKIYTI  60
   61 PLTLSEWEVL TSLCVAIPTT LDLVETMLKE IIAPYFLETP RQRISDVLSS KFKLEQMRNP 120
  121 IELLTFQLTK FMIQACEQYP VLYENIGGII STYFERVLKI FTIKQSGLLS LVGFINAFIQ 180
  181 FPNSTELTKF TWKKLAKLVL RGSFLNEVDK ILNSSATFTN DSIVQYYDAG NELSSAYLLE 240
  241 LISRLQVSLI SHLLNTSHVG ANLSEFLLNQ QYQFYKFDQE VADENDDTKC IDDFFFNVRS 300
  301 NKQFFTDMCK ISLQFCSESH ILDLSTDNRA RFSFDTRAHY LQTLCLIPFI EDTESELFES 360
  361 FTNVVSESID KFFLSDVVTP SLIKAIVASA SLLNFFTEKL SLTLIRMFPL LVASPHITTE 420
  421 TVNDVAKIFT TGLYPLNEDA IVSTIYSMNN LLAVSEDGSP VPVLRERQLT ITSGKNIEKD 480
  481 YFPLRNSSAS LDGTGALLGN TTVGQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [506-817] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSSHDVNSGA TMTYHASLIS NCVAATTTIA SYYNTQSITA LTISILTQKV NSMSKELDGV  60
   61 ILNSLARLAP NTSLTEFSLL LKFFKSRTVI ATKIDDSALL KNIIKAKCVI SKELLARHFS 120
  121 SDLYFMYLHD LLDSIIASGE VERLEHHRPQ TEISRVADQI ATYLEPLAAL LPVPGDTPLD 180
  181 INKDEVTTNK FRNAWFNFVI HGYHLGGPIV KRNFSFLLTI AYNSPPLASE FPANNKELSL 240
  241 EMNTILRRGS SNENIKQQKQ QITEYFNTNI VQYRTTSSSK IMFLAAAVLL ETIRCEAGDC 300
  301 SKTLLYFSDP SI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [818-1280] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSGSIEKCIA VLSVSMIRKY ARLIQKGNDA IFNSKMIAQQ LNNLLLCLSH REPTLQDAAF  60
   61 HACEIFIRSI PSSLCHHLSL YTLLDMLTAL FDSILDSEAH KFEPRYEFKL KHSKTTILVP 120
  121 SSSSWRATTL SRLHKSAKEW VRILLNRSNQ DTKILLQSYI SDLGEYSRLN SVEFGVSFAM 180
  181 DMAGLILPAD KELSRLTYYG PEKPNTISGF ISLHSWRSKY LFDTAITSSP EDIKRQIGIS 240
  241 TQNIRKNLTL GNKIITKDVT DFLDMATALL ILGNGAPASL IYDIVHIPFE VFTSASLKIA 300
  301 TNVWLTIITE KPEVAHLLLV EVCYCWMRSI DDNIGLYSRD HDLKGEEYQK MEYSPYDKAG 360
  361 INRDAKNASQ AMQPHLHVIK FFASHFEGTL FQSDFLLKIF TKCALYGIKN LYKASLHPFA 420
  421 RMIRHELLLF ATLVLNASYK QGSKYMGRLS QEITNGALSW FKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein transporter activity 3.54751411727402 bayes_pls_golite062009
transporter activity 2.3766833486706 bayes_pls_golite062009
binding 2.08129940242136 bayes_pls_golite062009
protein binding 2.0097220759196 bayes_pls_golite062009
substrate-specific transporter activity 1.87445049214426 bayes_pls_golite062009
protein transmembrane transporter activity 1.29496918547173 bayes_pls_golite062009
transmembrane transporter activity 1.2724388835449 bayes_pls_golite062009
protein kinase activity 0.810649007742052 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.80477645195818 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.458765492668419 bayes_pls_golite062009
kinase activity 0.457930590956078 bayes_pls_golite062009
nuclear localization sequence binding 0.446146092845179 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.325164716012293 bayes_pls_golite062009
clathrin binding 0.267269093785234 bayes_pls_golite062009
active transmembrane transporter activity 0.260663498540354 bayes_pls_golite062009
protein serine/threonine kinase activity 0.109457212542021 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0128158555898987 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00672548245940896 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1281-1544] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVAWPFGSNE LKIKADLSVT RDLFLQLNKL SSLMSRHCGK DYKILNYFLA SEIQQIQTWL  60
   61 TPTEKIEGAD SNELTSDIVE ATFAKDPTLA INLLQRCYSK KAEDVLVGLV AKHALMCVGS 120
  121 PSALDLFIKG SHLSSKKDLH ATLYWAPVSP LKSINLFLPE WQGNSFILQF SIYSLESQDV 180
  181 NLAFFYVPQI VQCLRYDKTG YVERLILDTA KISVLFSHQI IWNMLANCYK DDEGIQEDEI 240
  241 KPTLDRIRER MVSSFSQSHR DFYE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 451.9794
Match: 1he8A_
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1545-1659] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REFEFFDEVT GISGKLKPYI KKSKAEKKHK IDEEMSKIEV KPDVYLPSNP DGVVIDIDRK  60
   61 SGKPLQSHAK APFMATFKIK KDVKDPLTGK NKEVEKWQAA IFKVGDDCRQ DVLAL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1681-1696] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRVTATAPGC GVIDVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 451.9794
Match: 1he8A_
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [1660-1680] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLISLFRTIW SSIGLDVYVF P

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1697-1900] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNSVSRDMLG REAVNGLYEY FTSKFGNEST IEFQNARNNF VKSLAGYSVI SYLLQFKDRH  60
   61 NGNIMYDDQG HCLHIDFGFI FDIVPGGIKF EAVPFKLTKE MVKVMGGSPQ TPAYLDFEEL 120
  121 CIKAYLAARP HVEAIIECVN PMLGSGLPCF KGHKTIRNLR ARFQPQKTDH EAALYMKALI 180
  181 RKSYESIFTK GYDEFQRLTN GIPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 451.9794
Match: 1he8A_
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1281-1900] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVAWPFGSNE LKIKADLSVT RDLFLQLNKL SSLMSRHCGK DYKILNYFLA SEIQQIQTWL  60
   61 TPTEKIEGAD SNELTSDIVE ATFAKDPTLA INLLQRCYSK KAEDVLVGLV AKHALMCVGS 120
  121 PSALDLFIKG SHLSSKKDLH ATLYWAPVSP LKSINLFLPE WQGNSFILQF SIYSLESQDV 180
  181 NLAFFYVPQI VQCLRYDKTG YVERLILDTA KISVLFSHQI IWNMLANCYK DDEGIQEDEI 240
  241 KPTLDRIRER MVSSFSQSHR DFYEREFEFF DEVTGISGKL KPYIKKSKAE KKHKIDEEMS 300
  301 KIEVKPDVYL PSNPDGVVID IDRKSGKPLQ SHAKAPFMAT FKIKKDVKDP LTGKNKEVEK 360
  361 WQAAIFKVGD DCRQDVLALQ LISLFRTIWS SIGLDVYVFP YRVTATAPGC GVIDVLPNSV 420
  421 SRDMLGREAV NGLYEYFTSK FGNESTIEFQ NARNNFVKSL AGYSVISYLL QFKDRHNGNI 480
  481 MYDDQGHCLH IDFGFIFDIV PGGIKFEAVP FKLTKEMVKV MGGSPQTPAY LDFEELCIKA 540
  541 YLAARPHVEA IIECVNPMLG SGLPCFKGHK TIRNLRARFQ PQKTDHEAAL YMKALIRKSY 600
  601 ESIFTKGYDE FQRLTNGIPY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 145.0
Match: 1he8A
Description: Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 4.85949258240629 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.32184067232044 bayes_pls_golite062009
kinase activity 4.16135267871365 bayes_pls_golite062009
protein serine/threonine kinase activity 3.92556971928915 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 3.76541923765309 bayes_pls_golite062009
transferase activity 2.57136779276375 bayes_pls_golite062009
protein tyrosine kinase activity 2.49185236546092 bayes_pls_golite062009
phosphoinositide 3-kinase activity 2.44230772088939 bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity 2.31725772204126 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.10205527715406 bayes_pls_golite062009
binding 1.86908674572736 bayes_pls_golite062009
receptor signaling protein activity 1.78809750269485 bayes_pls_golite062009
ATP binding 1.62950013799854 bayes_pls_golite062009
protein transmembrane transporter activity 1.62540675397712 bayes_pls_golite062009
protein binding 1.62406684925162 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.61399284935575 bayes_pls_golite062009
adenyl ribonucleotide binding 1.59120412984243 bayes_pls_golite062009
adenyl nucleotide binding 1.57251948653832 bayes_pls_golite062009
SNARE binding 1.50911134971955 bayes_pls_golite062009
calcium-dependent phospholipid binding 1.48140651026963 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.47984425211758 bayes_pls_golite062009
ribonucleotide binding 1.32931505255952 bayes_pls_golite062009
purine ribonucleotide binding 1.32676572752438 bayes_pls_golite062009
purine nucleotide binding 1.31489723493061 bayes_pls_golite062009
nucleotide binding 1.31339663939554 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
molecular transducer activity 1.08569774189413 bayes_pls_golite062009
signal transducer activity 1.08569774189413 bayes_pls_golite062009
transmembrane receptor activity 1.05349866588938 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
nuclear localization sequence binding 0.865986250813399 bayes_pls_golite062009
platelet-derived growth factor receptor binding 0.863546778345754 bayes_pls_golite062009
syntaxin binding 0.860722375330019 bayes_pls_golite062009
phospholipase C activity 0.7749932550949 bayes_pls_golite062009
lipid kinase activity 0.74363752721495 bayes_pls_golite062009
phospholipase activity 0.689713182053935 bayes_pls_golite062009
receptor activity 0.565672931530981 bayes_pls_golite062009
clathrin binding 0.53271167669517 bayes_pls_golite062009
substrate-specific transporter activity 0.451090007290896 bayes_pls_golite062009
nuclear export signal receptor activity 0.407635284358481 bayes_pls_golite062009
inositol or phosphatidylinositol kinase activity 0.328918574945998 bayes_pls_golite062009
protein transporter activity 0.322729515821394 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.205652638854091 bayes_pls_golite062009
magnesium ion binding 0.134745748018448 bayes_pls_golite062009
neurexin binding 0.10203540130895 bayes_pls_golite062009
growth factor binding 0.0282286028179795 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009
primary active transmembrane transporter activity 0.00492507437049428 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle