YRC Public Data Repository - Protein Structure Prediction

Protein:	MAS1
Organism:	Saccharomyces cerevisiae
Length:	462 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAS1.

Description	E-value	Query Range	Subject Range
gi\|3342006, gi\|4... - gi\|4758734\|ref\|NP_004270.1\| peptidase (mitochondrial processing) beta [Homo sapiens], gi\|3342006\|gb\|...	0.0	[8..460]	[41..484]
MPPB_MOUSE - Mitochondrial-processing peptidase subunit beta OS=Mus musculus GN=Pmpcb PE=1 SV=1	0.0	[8..460]	[41..484]
MAS1 - Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cle... MPPB_YEAST - Mitochondrial-processing peptidase subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...	0.0	[1..462]	[1..462]
gi\|397699 - gi\|397699\|dbj\|BAA03007.1\| mitochondrial processing protease [Rattus norvegicus]	0.0	[8..460]	[39..482]
gi\|195570810, gi... - gi\|195570810\|ref\|XP_002103397.1\| GD18983 [Drosophila simulans], gi\|194199324\|gb\|EDX12900.1\| GD18983 ... gi\|220945206, gi... - gi\|220955020\|gb\|ACL90053.1\| CG3731-PA [synthetic construct], gi\|220945206\|gb\|ACL85146.1\| CG3731-PA [... gi\|195328891, gi... - gi\|195328891\|ref\|XP_002031145.1\| GM24191 [Drosophila sechellia], gi\|194120088\|gb\|EDW42131.1\| GM24191... CG3731-PB, CG3731-PA - This gene is referred to in FlyBase by the symbol Dmel\CG3731 (CG3731, FBgn0038271). It is a protein...	0.0	[1..460]	[21..465]
gi\|12802327 - gi\|12802327\|gb\|AAK07827.1\|AF297643_1 mitochondrial processing peptidase beta subunit [Cucumis melo]	0.0	[21..459]	[89..522]
MPPB_ARATH - Probable mitochondrial-processing peptidase subunit beta, mitochondrial OS=Arabidopsis thaliana GN=A...	0.0	[15..459]	[86..525]
QCR1_BOVIN - Cytochrome b-c1 complex subunit 1, mitochondrial OS=Bos taurus GN=UQCRC1 PE=1 SV=2	0.0	[4..460]	[27..475]

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Predicted Domain #1

Region A:
Residues: [1-155]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRTASKFR NTRRLLSTIS SQIPGTRTSK LPNGLTIATE YIPNTSSATV GIFVDAGSRA  60
   61 ENVKNNGTAH FLEHLAFKGT QNRSQQGIEL EIENIGSHLN AYTSRENTVY YAKSLQEDIP 120
  121 KAVDILSDIL TKSVLDNSAI ERERDVIIRE SEEVD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [174-247]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QPLGRTILGP IKNIKSITRT DLKDYITKNY KGDRMVLAGA GAVDHEKLVQ YAQKYFGHVP  60
   61 KSESPVPLGS PRGP

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [387-411]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDGSTAIVE DIGRQVVTTG KRLSP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10127.0
Match:	1hr6B_
Description:	Mitochondrial processing peptidase (MPP) beta chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	10.0305725791312	bayes_pls_golite062009
ubiquinol-cytochrome-c reductase activity	10.0305725791312	bayes_pls_golite062009
metallopeptidase activity	7.31794755224524	bayes_pls_golite062009
metalloendopeptidase activity	7.31174048559335	bayes_pls_golite062009
peptidase activity	7.05972470989638	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors	6.64269017601856	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.57226784092621	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.17510847735476	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.03221088799464	bayes_pls_golite062009
oxidoreductase activity	3.89224384280888	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.48526983761385	bayes_pls_golite062009
endopeptidase activity	3.25021389096625	bayes_pls_golite062009
hydrolase activity	2.79262298779436	bayes_pls_golite062009
transporter activity	1.55442313420533	bayes_pls_golite062009
binding	1.51460850438647	bayes_pls_golite062009
transmembrane transporter activity	1.40378628474509	bayes_pls_golite062009
catalytic activity	1.30647052031202	bayes_pls_golite062009
substrate-specific transporter activity	1.29599547747567	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.16717310870379	bayes_pls_golite062009
signal transducer activity	1.12122807250795	bayes_pls_golite062009
molecular transducer activity	1.12122807250795	bayes_pls_golite062009
ion transmembrane transporter activity	1.05022391589259	bayes_pls_golite062009
cation transmembrane transporter activity	0.961854978876222	bayes_pls_golite062009
protein binding	0.236143103582996	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.11486391789734	bayes_pls_golite062009
pyrophosphatase activity	0.077701103001661	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0688257218639591	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0662171656580391	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [156-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMYDEVVFDH LHEITYKD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [248-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPVFCRGERF IKENTLPTTH IAIALEGVSW SAPDYFVALA TQAIVGNWDR AIGTGTNSPS  60
   61 PLAVAASQNG SLANSYMSFS TSYADSGLWG MYIVTDSNEH NVQLIVNEIL KEWKRIKSGK 120
  121 ISDAEVNRAK AQLKAALLL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [412-462]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEVFEQVDKI TKDDIIMWAN YRLQNKPVSM VALGNTSTVP NVSYIEEKLN Q

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10127.0
Match:	1hr6B_
Description:	Mitochondrial processing peptidase (MPP) beta chain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: