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View Structure Prediction Details

Protein: MLP1
Organism: Saccharomyces cerevisiae
Length: 1875 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MLP1.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 0.0 [460..1635] [734..1937]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 0.0 [460..1630] [737..1935]
MYH1B_CHICK - Myosin-1B OS=Gallus gallus GN=MYH1B PE=2 SV=3
 0.0 [460..1635] [737..1940]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [460..1635] [737..1940]
gi|179508, gi|10... - sp|P12883|MYH7_HUMAN Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta), gi|4557773|ref|NP...
 0.0 [460..1630] [732..1930]
MYSS_CYPCA - Myosin heavy chain, fast skeletal muscle OS=Cyprinus carpio PE=2 SV=2
 0.0 [460..1634] [733..1935]

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Predicted Domain #1
Region A:
Residues: [1-103] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDHDTPMES IQNGENSDER LNAIASFFGC SLEQVKSFDG DVVKHLNDKL LQFNELKSEN  60
   61 LKVTVSFDEL KASSLKKIDG LKTEMENVIR ENDKIRKERN DTF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [104-327] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKFESVENEK MKLSSELEFV KRKLDDLTEE KKETQSNQQR TLKILDERLK EIELVRVENN  60
   61 RSNSECKKLR STIMDLETKQ QGYITNDLNS RTELERKTQE LTLLQSNNDW LEKELRSKNE 120
  121 QYLSYRQKTD KVILDIRNEL NRLRNDFQME RTNNDVLKQK NNELSKSLQE KLLEIKGLSD 180
  181 SLNSEKQEFS AEMSLKQRLV DLLESQLNAV KEELNSIREL NTAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.0
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [328-450] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIADDSKKQT PENEDLLKEL QLTKEKLAQC EKECLRLSSI TDEADEDNEN LSAKSSSDFI  60
   61 FLKKQLIKER RTKEHLQNQI ETFIVELEHK VPIINSFKER TDMLENELNN AALLLEHTSN 120
  121 EKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.975 0.009 nuclear envelope a.47.2 t-snare proteins

Predicted Domain #4
Region A:
Residues: [451-602] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKVKELNAKN QKLVECENDL QTLTKQRLDL CRQIQYLLIT NSVSNDSKGP LRKEEIQFIQ  60
   61 NIMQEDDSTI TESDSQKVVT ERLVEFKNII QLQEKNAELL KVVRNLADKL ESKEKKSKQS 120
  121 LQKIESETVN EAKEAIITLK SEKMDLESRI EE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [603-901] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQKELEELKT SVPNEDASYS NVTIKQLTET KRDLESQVQD LQTRISQITR ESTENMSLLN  60
   61 KEIQDLYDSK SDISIKLGKE KSSRILAEER FKLLSNTLDL TKAENDQLRK RFDYLQNTIL 120
  121 KQDSKTHETL NEYVSCKSKL SIVETELLNL KEEQKLRVHL EKNLKQELNK LSPEKDSLRI 180
  181 MVTQLQTLQK EREDLLEETR KSCQKKIDEL EDALSELKKE TSQKDHHIKQ LEEDNNSNIE 240
  241 WYQNKIEALK KDYESVITSV DSKQTDIEKL QYKVKSLEKE IEEDKIRLHT YNVMDETIN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
cytoskeletal protein binding 1.24134446233807 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
actin binding 0.6102552688489 bayes_pls_golite062009
molecular transducer activity 0.515227322986114 bayes_pls_golite062009
signal transducer activity 0.515227322986114 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.377270323657906 bayes_pls_golite062009
receptor activity 0.361249991204582 bayes_pls_golite062009
RNA binding 0.329588635205335 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
transmembrane receptor activity 0.147724557486814 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [902-1421] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDSLRKELEK SKINLTDAYS QIKEYKDLYE TTSQSLQQTN SKLDESFKDF TNQIKNLTDE  60
   61 KTSLEDKISL LKEQMFNLNN ELDLQKKGME KEKADFKKRI SILQNNNKEV EAVKSEYESK 120
  121 LSKIQNDLDQ QTIYANTAQN NYEQELQKHA DVSKTISELR EQLHTYKGQV KTLNLSRDQL 180
  181 ENALKENEKS WSSQKESLLE QLDLSNSRIE DLSSQNKLLY DQIQIYTAAD KEVNNSTNGP 240
  241 GLNNILITLR RERDILDTKV TVAERDAKML RQKISLMDVE LQDARTKLDN SRVEKENHSS 300
  301 IIQQHDDIME KLNQLNLLRE SNITLRNELE NNNNKKKELQ SELDKLKQNV APIESELTAL 360
  361 KYSMQEKEQE LKLAKEEVHR WKKRSQDILE KHEQLSSSDY EKLESEIENL KEELENKERQ 420
  421 GAEAEEKFNR LRRQAQERLK TSKLSQDSLT EQVNSLRDAK NVLENSLSEA NARIEELQNA 480
  481 KVAQGNNQLE AIRKLQEDAE KASRELQAKL EESTTSYEST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1422-1507] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INGLNEEITT LKEEIEKQRQ IQQQLQATSA NEQNDLSNIV ESMKKSFEED KIKFIKEKTQ  60
   61 EVNEKILEAQ ERLNQPSNIN MEEIKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.678 0.829 nuclear envelope a.118.1 ARM repeat

Predicted Domain #8
Region A:
Residues: [1508-1875] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWESEHEQEV SQKIREAEEA LKKRIRLPTE EKINKIIERK KEELEKEFEE KVEERIKSME  60
   61 QSGEIDVVLR KQLEAKVQEK QKELENEYNK KLQEELKDVP HSSHISDDER DKLRAEIESR 120
  121 LREEFNNELQ AIKKKSFDEG KQQAMMKTTL LERKLAKMES QLSETKQSAE SPPKSVNNVQ 180
  181 NPLLGLPRKI EENSNSPFNP LLSGEKLLKL NSKSSSGGFN PFTSPSPNKH LQNDNDKRES 240
  241 LANKTDPPTH LEPSFNIPAS RGLISSSSTL STDTNDEELT SNNPAQKDSS NRNVQSEEDT 300
  301 EKKKEGEPVK RGEAIEEQTK SNKRPIDEVG ELKNDEDDTT ENINESKKIK TEDEEEKETD 360
  361 KVNDENSI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.62
Match: 1k83A
Description: RBP1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle