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View Structure Prediction Details

Protein: VPS1
Organism: Saccharomyces cerevisiae
Length: 704 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS1.

Description E-value Query
Range		 Subject
Range
gi|207343428 - gi|207343428|gb|EDZ70888.1| YKR001Cp-like protein [Saccharomyces cerevisiae AWRI1631]
VPS1_YEAST - Vacuolar protein sorting-associated protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
gi|151941546 - gi|151941546|gb|EDN59909.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
VPS1 - Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization,...
 0.0 [1..704] [1..704]
gi|4868358 - gi|4868358|gb|AAD31278.1| dynamin-like protein DLP1 isoform DLP1-37 [Rattus norvegicus]
 0.0 [3..704] [2..712]
gi|17148576 - gi|17148576|dbj|BAB78398.1| VpsA [Emericella nidulans]
gi|67902072, gi|... - gi|67902072|ref|XP_681292.1| hypothetical protein AN8023.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
 0.0 [2..704] [14..695]
gi|74186203, gi|... - gi|74186203|dbj|BAE42897.1| unnamed protein product [Mus musculus], gi|12836637|dbj|BAB23745.1| unna...
 0.0 [3..704] [7..739]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [3..704] [7..739]

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Predicted Domain #1
Region A:
Residues: [1-356] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEHLISTIN KLQDALAPLG GGSQSPIDLP QITVVGSQSS GKSSVLENIV GRDFLPRGTG  60
   61 IVTRRPLVLQ LINRRPKKSE HAKVNQTANE LIDLNINDDD KKKDESGKHQ NEGQSEDNKE 120
  121 EWGEFLHLPG KKFYNFDEIR KEIVKETDKV TGANSGISSV PINLRIYSPH VLTLTLVDLP 180
  181 GLTKVPVGDQ PPDIERQIKD MLLKYISKPN AIILSVNAAN TDLANSDGLK LAREVDPEGT 240
  241 RTIGVLTKVD LMDQGTDVID ILAGRVIPLR YGYIPVINRG QKDIEHKKTI REALENERKF 300
  301 FENHPSYSSK AHYCGTPYLA KKLNSILLHH IRQTLPEIKA KIEATLKKYQ NELINL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1185.0
Match: 1jwyB_
Description: Dynamin G domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.74389108884083 bayes_pls_golite062009
pyrophosphatase activity 2.67097555143215 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.65161658635465 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.64849912301318 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
ATPase activity 2.2625504298178 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
binding 2.01755875920323 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
motor activity 1.47133910026814 bayes_pls_golite062009
protein transporter activity 1.37245678118001 bayes_pls_golite062009
hydrolase activity 1.34710139310747 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
microfilament motor activity 0.723407201613229 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
cytoskeletal protein binding 0.568484017802328 bayes_pls_golite062009
actin binding 0.563996324417607 bayes_pls_golite062009
protein transmembrane transporter activity 0.46552249844591 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
signal recognition particle binding 0.29390189699022 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
protein binding 0.071010918255742 bayes_pls_golite062009
nucleic acid binding 0.0636334376764289 bayes_pls_golite062009
molecular transducer activity 0.0529006651532686 bayes_pls_golite062009
signal transducer activity 0.0529006651532686 bayes_pls_golite062009
macromolecule transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009
P-P-bond-hydrolysis-driven protein transmembrane transporter activity 0.00571427458217011 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [357-583] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPETMDSASS VVLSMITDFS NEYAGILDGE AKELSSQELS GGARISYVFH ETFKNGVDSL  60
   61 DPFDQIKDSD IRTIMYNSSG SAPSLFVGTE AFEVLVKQQI RRFEEPSLRL VTLVFDELVR 120
  121 MLKQIISQPK YSRYPALREA ISNQFIQFLK DATIPTNEFV VDIIKAEQTY INTAHPDLLK 180
  181 GSQAMVMVEE KLHPRQVAVD PKTGKPLPTQ PSSSKAPVME EKSGFFG

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 42.69897
Match: PF01031
Description: Dynamin central region

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [584-704] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFFSTKNKKK LAALESPPPV LKATGQMTER ETMETEVIKL LISSYFSIVK RTIADIIPKA  60
   61 LMLKLIVKSK TDIQKVLLEK LYGKQDIEEL TKENDITIQR RKECKKMVEI LRNASQIVSS 120
  121 V

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.173925
Match: PF02212
Description: Dynamin GTPase effector domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [600-704] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPVLKATGQ MTERETMETE VIKLLISSYF SIVKRTIADI IPKALMLKLI VKSKTDIQKV  60
   61 LLEKLYGKQD IEELTKENDI TIQRRKECKK MVEILRNASQ IVSSV

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 40.187087
Match: PF02212.9
Description: No description for PF02212.9 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.896 0.059 mitochondrial outer membrane a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.902 0.041 mitochondrial outer membrane a.7.1 Spectrin repeat
View Download 0.860 0.034 mitochondrial outer membrane a.47.2 t-snare proteins
View Download 0.915 0.006 mitochondrial outer membrane f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.907 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle