YRC Public Data Repository - Protein Structure Prediction

Protein:	SMY1
Organism:	Saccharomyces cerevisiae
Length:	656 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMY1.

Description	E-value	Query Range	Subject Range
gi\|168267318 - gi\|168267318\|dbj\|BAG09715.1\| kinesin family member 3B [synthetic construct] gi\|114681458, gi... - gi\|114681460\|ref\|XP_001155482.1\| PREDICTED: kinesin family member 3B isoform 2 [Pan troglodytes], gi... KIF3B - kinesin family member 3B	0.0	[19..648]	[1..646]
gi\|13235654, gi\|... - gi\|148228464\|ref\|NP_001084268.1\| minesin-like protein [Xenopus laevis], gi\|13235654\|emb\|CAC33801.1\| ...	0.0	[21..621]	[8..588]
FLA10_CHLRE - Kinesin-like protein FLA10 OS=Chlamydomonas reinhardtii GN=FLA10 PE=1 SV=1	0.0	[26..618]	[9..621]
gi\|9800183 - gi\|9800183\|gb\|AAF99085.1\|AF149286_1 KRP95 [Caenorhabditis elegans]	0.0	[19..606]	[5..578]
gi\|8248421 - gi\|8248421\|gb\|AAF74192.1\|AF247761_1 kinesin superfamily member DUnc104 [Drosophila melanogaster]	0.0	[26..628]	[2..638]
SMY1 - Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is relat... SMY1_YEAST - Kinesin-related protein SMY1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SMY1 PE=1 S...	0.0	[1..644]	[1..644]
KRP85_STRPU - Kinesin-II 85 kDa subunit OS=Strongylocentrotus purpuratus GN=KRP85 PE=1 SV=1	0.0	[22..621]	[5..586]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	0.0	[1..644]	[1..644]

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Predicted Domain #1

Region A:
Residues: [1-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHWNIISKEQ SSSSVSLPTL DSSEPCHIEV ILRAIPEKGL QNNESTFKID PYENTVLFRT  60
   61 NNPLHETTKE THSTFQFDKV FDANATQEDV QKFLVHPIIN DVLNGYNGTV ITYGPSFSGK 120
  121 SYSLIGSKES EGILPNICKT LFDTLEKNEE TKGDSFSVSV LAFEIYMEKT YDLLVPLPER 180
  181 KPLKLHRSSS KMDLEIKDIC PAHVGSYEDL RSYIQAVQNV GNRMACGDKT ERSRSHLVFQ 240
  241 LHVEQRNRKD DILKNSSLYL VDLHGAEKFD KRTESTLSQD ALKKLNQSIE ALKNTVRSLS 300
  301 MKERDSAYSA KGSHSSAYRE SQLTEVLKDS LGGNRKTKVI LTCFLSNVPT TLSTLEFGDS 360
  361 IRQINN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	523.228787
Match:	1gojA_
Description:	Kinesin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphatase activity	2.28726855139279	bayes_pls_golite062009
pyrophosphatase activity	2.23754609668547	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.21702600128327	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.21503003850174	bayes_pls_golite062009
transporter activity	1.85044926113762	bayes_pls_golite062009
ATPase activity	1.70670922135201	bayes_pls_golite062009
transmembrane transporter activity	1.656935231793	bayes_pls_golite062009
ATPase activity, coupled	1.5648315540069	bayes_pls_golite062009
binding	1.55526868300981	bayes_pls_golite062009
hydrolase activity	1.20846280768115	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
protein binding	0.569246647740442	bayes_pls_golite062009
substrate-specific transporter activity	0.464456497491373	bayes_pls_golite062009
catalytic activity	0.458437698837681	bayes_pls_golite062009
active transmembrane transporter activity	0.434775387083003	bayes_pls_golite062009
microfilament motor activity	0.424639191768109	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
primary active transmembrane transporter activity	0.294474570607914	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.282352478532746	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.220608508617331	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.219533217661421	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.219157471322311	bayes_pls_golite062009
cytoskeletal protein binding	0.173467228941698	bayes_pls_golite062009
GTPase activity	0.105546189348878	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.0756212238097211	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [367-656]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVTDNTTGLN LKKKMDLFIQ DMKIKDDNYV AQINILKAEI DSLKSLHNKS LPEDDEKKML  60
   61 ENTKKENIKL KLQLDSITQL LSSSTNEDPN NRIDEEVSEI LTKRCEQIAQ LELSFDRQMN 120
  121 SNSKLQQELE YKKSKEEALE SMNVRLLEQI QLQEREIQEL LTTNAILKGE LETHTKLTET 180
  181 RSERIKSLES SVKELSLNKS AIPSPRRGSM SSSSGNTMLH IEEGSEISNS PWSANTSSKP 240
  241 LVWGARKVSS SSIATTGSQE SFVARPFKKG LNLHSIKVTS STPKSPSSGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.69897
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: