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View Structure Prediction Details

Protein: YUH1
Organism: Saccharomyces cerevisiae
Length: 236 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YUH1.

Description E-value Query
Range
Subject
Range
gi|7710106, gi|7... - gi|7710106|ref|NP_057932.1| ubiquitin carboxyl-terminal esterase L3 [Mus musculus], gi|7578956|gb|AA...
2.0E-82 [4..231] [2..227]
gi|61355555 - gi|61355555|gb|AAX41152.1| ubiquitin carboxyl-terminal esterase L3 [synthetic construct]
ENSPTRT00000010892 - null
UCHL3 - ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
tr|M3WRI6|M3WRI6... - Ubiquitin carboxyl-terminal hydrolase OS=Felis catus GN=UCHL3 PE=3 SV=1
4.0E-82 [4..231] [2..227]
UCHL3_RAT - Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Rattus norvegicus GN=Uchl3 PE=1 SV=1
1.0E-80 [4..231] [2..227]

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Predicted Domain #1
Region A:
Residues: [1-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGENRAVVP IESNPEVFTN FAHKLGLKNE WAYFDIYSLT EPELLAFLPR PVKAIVLLFP  60
   61 INEDRKSSTS QQITSSYDVI WFKQSVKNAC GLYAILHSLS NNQSLLEPGS DLDNFLKSQS 120
  121 DTSSSKNRFD DVTTDQFVLN VIKENVQTFS TGQSEAPEAT ADTNLHYITY VEENGGIFEL 180
  181 DGRNLSGPLY LGKSDPTATD LIEQELVRVR VASYMENANE EDVLNFAMLG LGPNWE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1337.522879
Match: 1cmxA_
Description: Ubiquitin carboxyl-terminal hydrolase UCH-l3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
peptidase activity 1.2363147273892 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.10408384086394 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.854677025220204 bayes_pls_golite062009
hydrolase activity 0.785819892845781 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
cysteine-type endopeptidase activity 0.519017048367076 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
endopeptidase activity 0.415253171908598 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle