| Protein: | TOK1 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 691 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TOK1.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..691] | [1..691] |
|
|
6.0E-85 | [18..344] | [158..487] |
|
|
1.0E-84 | [18..344] | [170..499] |
|
|
2.0E-83 | [18..354] | [130..464] |
|
|
7.0E-83 | [18..331] | [182..512] |
|
|
2.0E-82 | [18..362] | [106..449] |
|
Region A: Residues: [1-117] |
1 11 21 31 41 51
| | | | | |
1 MTRFMNSFAK QTLGYGNMAT VEQESSAQAV DSHSNNTPKQ AKGVLAEELK DALRFRDERV 60
61 SIINAEPSST LFVFWFVVSC YFPVITACLG PVANTISIAC VVEKWRSLKN NSVVTNP
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.437 | 0.028 | potassium channel activity | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.367 | 0.012 | potassium channel activity | d.89.1 | Origin of replication-binding domain, RBD-like |
| View | Download | 0.428 | 0.010 | potassium channel activity | a.29.2 | Bromodomain |
| View | Download | 0.524 | 0.002 | potassium channel activity | d.58.44 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains |
| View | Download | 0.374 | N/A | N/A | c.114.1 | YchN-like |
| View | Download | 0.358 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.357 | N/A | N/A | c.95.1 | Thiolase-like |
| View | Download | 0.346 | N/A | N/A | d.110.4 | SNARE-like |
| View | Download | 0.346 | N/A | N/A | d.233.1 | Inhibitor of vertebrate lysozyme, Ivy |
| View | Download | 0.345 | N/A | N/A | b.52.1 | Barwin-like endoglucanases |
| View | Download | 0.341 | N/A | N/A | c.23.1 | CheY-like |
| View | Download | 0.329 | N/A | N/A | d.218.1 | Nucleotidyltransferase |
| View | Download | 0.327 | N/A | N/A | d.110.1 | Profilin (actin-binding protein) |
| View | Download | 0.326 | N/A | N/A | d.185.1 | LuxS/MPP-like metallohydrolase |
| View | Download | 0.320 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.315 | N/A | N/A | c.51.1 | Anticodon-binding domain of Class II aaRS |
| View | Download | 0.308 | N/A | N/A | c.52.1 | Restriction endonuclease-like |
| View | Download | 0.301 | N/A | N/A | d.88.1 | SRF-like |
| View | Download | 0.300 | N/A | N/A | c.23.12 | Formate/glycerate dehydrogenase catalytic domain-like |
| View | Download | 0.296 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.291 | N/A | N/A | d.92.2 | beta-N-acetylhexosaminidase-like domain |
| View | Download | 0.287 | N/A | N/A | d.232.1 | Mago nashi protein |
| View | Download | 0.273 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.273 | N/A | N/A | c.23.1 | CheY-like |
| View | Download | 0.272 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.272 | N/A | N/A | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.267 | N/A | N/A | d.26.1 | FKBP-like |
| View | Download | 0.265 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.264 | N/A | N/A | d.52.3 | Prokaryotic type KH domain (KH-domain type II) |
| View | Download | 0.260 | N/A | N/A | d.187.1 | Photosystem I subunit PsaD |
| View | Download | 0.260 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.260 | N/A | N/A | c.2.1 | NAD(P)-binding Rossmann-fold domains |
| View | Download | 0.259 | N/A | N/A | c.23.12 | Formate/glycerate dehydrogenase catalytic domain-like |
| View | Download | 0.249 | N/A | N/A | d.74.1 | Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH) |
| View | Download | 0.247 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.246 | N/A | N/A | d.81.1 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain |
| View | Download | 0.239 | N/A | N/A | c.16.1 | Lumazine synthase |
| View | Download | 0.234 | N/A | N/A | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
| View | Download | 0.226 | N/A | N/A | d.58.18 | Regulatory domain in the aminoacid metabolism |
| View | Download | 0.226 | N/A | N/A | d.58.7 | RNA-binding domain, RBD |
| View | Download | 0.218 | N/A | N/A | d.155.1 | Pyruvoyl-dependent histidine and arginine decarboxylases |
| View | Download | 0.218 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.217 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.213 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.212 | N/A | N/A | d.16.1 | FAD-linked reductases, C-terminal domain |
| View | Download | 0.211 | N/A | N/A | c.2.1 | NAD(P)-binding Rossmann-fold domains |
| View | Download | 0.210 | N/A | N/A | d.93.1 | SH2 domain |
| View | Download | 0.208 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.208 | N/A | N/A | d.39.1 | Dynein light chain 8 (DLC8) |
| View | Download | 0.205 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
|
Region A: Residues: [118-194] |
1 11 21 31 41 51
| | | | | |
1 RSNDTDVLMN QVKTVFDPPG IFAVNIISLV LGFTSNIILM LHFSKKLTYL KSQLINITGW 60
61 TIAGGMLLVD VIVCSLN
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| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| potassium channel activity | 6.80950139957332 | bayes_pls_golite062009 |
| voltage-gated potassium channel activity | 6.78740036921969 | bayes_pls_golite062009 |
| voltage-gated cation channel activity | 6.69340621375858 | bayes_pls_golite062009 |
| voltage-gated ion channel activity | 6.55904318827964 | bayes_pls_golite062009 |
| voltage-gated channel activity | 6.55320598344395 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 5.06264960439093 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 4.86252983188139 | bayes_pls_golite062009 |
| cation channel activity | 4.85749153259346 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 4.77144021609018 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 4.3961579058414 | bayes_pls_golite062009 |
| gated channel activity | 4.19619757426613 | bayes_pls_golite062009 |
| inward rectifier potassium channel activity | 4.13359972196575 | bayes_pls_golite062009 |
| substrate-specific channel activity | 4.09858664479122 | bayes_pls_golite062009 |
| ion channel activity | 3.86720832958006 | bayes_pls_golite062009 |
| channel activity | 3.7587607940377 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 3.7587607940377 | bayes_pls_golite062009 |
| transporter activity | 2.93091397928047 | bayes_pls_golite062009 |
| transmembrane transporter activity | 2.82224868778929 | bayes_pls_golite062009 |
| monovalent inorganic cation transmembrane transporter activity | 2.63886826791804 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 2.54207434157938 | bayes_pls_golite062009 |
| ligand-gated ion channel activity | 2.26062383880472 | bayes_pls_golite062009 |
| ligand-gated channel activity | 2.26062383880472 | bayes_pls_golite062009 |
| inorganic cation transmembrane transporter activity | 1.88952785751441 | bayes_pls_golite062009 |
| catalytic activity | 1.79741889688267 | bayes_pls_golite062009 |
| hydrogen ion transmembrane transporter activity | 1.58358846593395 | bayes_pls_golite062009 |
| potassium ion transmembrane transporter activity | 1.57069429249737 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on CH-OH group of donors | 0.282641904073821 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.239024094835991 | bayes_pls_golite062009 |
| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 0.22529291758658 | bayes_pls_golite062009 |
| binding | 0.144628283348863 | bayes_pls_golite062009 |
|
Region A: Residues: [195-350] |
1 11 21 31 41 51
| | | | | |
1 DMPSIYSKTI GFWFACISSG LYLVCTIILT IHFIGYKLGK YPPTFNLLPN ERSIMAYTVL 60
61 LSLWLIWGAG MFSGLLHITY GNALYFCTVS LLTVGLGDIL PKSVGAKIMV LIFSLSGVVL 120
121 MGLIVFMTRS IIQKSSGPIF FFHRVEKGRS KSWKHY
|
| Detection Method: | |
| Confidence: | 10.57 |
| Match: | 1f6gA |
| Description: | Potassium channel protein |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [351-458] |
1 11 21 31 41 51
| | | | | |
1 MDSSKNLSER EAFDLMKCIR QTASRKQHWF SLSVTIAIFM AFWLLGALVF KFAENWSYFN 60
61 CIYFCFLCLL TIGYGDYAPR TGAGRAFFVI WALGAVPLMG AILSTVGD
|
| Detection Method: | |
| Confidence: | 57.512579 |
| Match: | 1lnqA_ |
| Description: | Potassium channel-related protein MthK |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [459-638] |
1 11 21 31 41 51
| | | | | |
1 LLFDISTSLD IKIGESFNNK VKSIVFNGRQ RALSFMVNTG EIFEESDTAD GDLEENTTSS 60
61 QSSQISEFND NNSEENDSGV TSPPASLQES FSSLSKASSP EGILPLEYVS SAEYALQDSG 120
121 TCNLRNLQEL LKAVKKLHRI CLADKDYTLS FSDWSYIHKL HLRNITDIEE YTRGPEFWIS 180
181
|
| Detection Method: | |
| Confidence: | 57.512579 |
| Match: | 1lnqA_ |
| Description: | Potassium channel-related protein MthK |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [639-691] |
1 11 21 31 41 51
| | | | | |
1 PDTPLKFPLN EPHFAFMMLF KNIEELVGNL VEDEELYKVI SKRKFLGEHR KTL
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.405 | a.5.2 | UBA-like |
| View | Download | 0.395 | a.55.1 | IHF-like DNA-binding proteins |
| View | Download | 0.393 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.368 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.306 | a.2.9 | C-terminal UvrC-binding domain of UvrB |
| View | Download | 0.292 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.250 | a.164.1 | C-terminal domain of DFF45/ICAD (DFF-C domain) |
| View | Download | 0.247 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.242 | d.58.36 | Sulfite reductase, domains 1 and 3 |
| View | Download | 0.230 | a.51.1 | Cytochrome c oxidase subunit h |
| View | Download | 0.230 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.206 | a.6.1 | Putative DNA-binding domain |
| View | Download | 0.200 | d.59.1 | Ribosomal protein L30p/L7e |
