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View Structure Prediction Details

Protein: PSF2
Organism: Saccharomyces cerevisiae
Length: 213 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PSF2.

Description E-value Query
Range
Subject
Range
gi|207344004 - gi|207344004|gb|EDZ71287.1| YJL072Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409427 - gi|190409427|gb|EDV12692.1| subunit of the GINS complex [Saccharomyces cerevisiae RM11-1a]
PSF2 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication orig...
gi|151945255 - gi|151945255|gb|EDN63504.1| GINS complex subunit [Saccharomyces cerevisiae YJM789]
PSF2_YEAST - DNA replication complex GINS protein PSF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
6.0E-80 [1..213] [1..213]
gi|5042457 - gi|5042457|gb|AAD38294.1|AC007789_20 unknown protein [Oryza sativa Japonica Group]
3.0E-59 [6..194] [8..179]
gi|55644351 - gi|55644351|ref|XP_511151.1| PREDICTED: similar to DNA replication complex GINS protein PSF2 (HSPC03...
GINS2 - GINS complex subunit 2 (Psf2 homolog)
2.0E-56 [15..197] [5..172]
PSF2_MOUSE - DNA replication complex GINS protein PSF2 OS=Mus musculus GN=Gins2 PE=1 SV=1
2.0E-56 [15..197] [5..172]
psf2 - GINS complex subunit Psf2
PSF2_SCHPO - DNA replication complex GINS protein psf2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...
3.0E-53 [1..195] [1..176]
gi|220948274, gi... - gi|220957452|gb|ACL91269.1| Psf2-PA [synthetic construct], gi|220948274|gb|ACL86680.1| Psf2-PA [synt...
Psf2-PA - The gene Psf2 is referred to in FlyBase by the symbol Dmel\Psf2 (CG18013, FBgn0031599). It is a prot...
4.0E-49 [13..199] [15..187]
CE17734 - status:Partially_confirmed UniProt:O62193 protein_id:CAB07195.1
3.0E-46 [14..185] [4..161]
PSF2_ENCCU - Probable DNA replication complex GINS protein PSF2 OS=Encephalitozoon cuniculi GN=ECU06_1410 PE=3 SV...
PSF2_ENCCU - Probable DNA replication complex GINS protein PSF2 OS=Encephalitozoon cuniculi (strain GB-M1) GN=ECU...
7.0E-45 [12..195] [4..168]
gi|16805258, gi|... - gi|7768290|emb|CAB11139.2| conserved Plasmodium protein, unknown function [Plasmodium falciparum 3D7...
0.003 [72..177] [356..476]

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Predicted Domain #1
Region A:
Residues: [1-115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPAHLQQT FSPEEIQFIV ENEPIKIFPR ITTRQKIRGD DRGTGNHTRW QLITTDDKAL  60
   61 NNMVAMRSTE VVLWIALLLK QQSKCSIVAP QWLTTKELDR KIQYEKTHPD RFSEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.523 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.201 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain

Predicted functions:

Term Confidence Notes
3'-5' DNA helicase activity 3.30007058745861 bayes_pls_golite062009
DNA helicase activity 2.7662250039458 bayes_pls_golite062009
binding 1.71578680186328 bayes_pls_golite062009
transcription regulator activity 1.2336233528067 bayes_pls_golite062009
helicase activity 1.2110072302388 bayes_pls_golite062009
protein binding 0.495328779211482 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.406116199163083 bayes_pls_golite062009
transcription elongation regulator activity 0.37490315580617 bayes_pls_golite062009
pyrophosphatase activity 0.350000641617868 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.33576520693158 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.333445385039412 bayes_pls_golite062009
catalytic activity 0.161911144249814 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [116-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PWNWLVLARI LFNKAKDDFH DPIHELRGKI QDLREIRQIK VLKGLKYLNE SHLQLDNLSL  60
   61 LEINELRPFI TEIMDKLREI HTASLTAGTE NDEEEFNI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.775 0.033 DNA binding a.24.9 alpha-catenin/vinculin
View Download 0.760 0.004 DNA-dependent DNA replication a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.754 0.003 DNA-dependent DNA replication a.2.7 tRNA-binding arm
View Download 0.780 N/A N/A i.1.1 Ribosome and ribosomal fragments
View Download 0.684 N/A N/A a.2.7 tRNA-binding arm
View Download 0.674 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.661 N/A N/A a.64.1 Saposin
View Download 0.643 N/A N/A a.7.1 Spectrin repeat
View Download 0.580 N/A N/A a.2.3 Chaperone J-domain
View Download 0.567 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.557 N/A N/A a.2.2 Ribosomal protein L29 (L29p)
View Download 0.554 N/A N/A a.60.2 RuvA domain 2-like
View Download 0.547 N/A N/A a.24.1 Apolipoprotein
View Download 0.539 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.516 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.504 N/A N/A a.25.1 Ferritin-like
View Download 0.490 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.467 N/A N/A a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.463 N/A N/A a.7.7 BAG domain
View Download 0.458 N/A N/A a.47.2 t-snare proteins
View Download 0.457 N/A N/A d.2.1 Lysozyme-like
View Download 0.453 N/A N/A a.4.12 TrpR-like
View Download 0.443 N/A N/A f.17.1 F1F0 ATP synthase subunit C
View Download 0.439 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.435 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.431 N/A N/A a.3.1 Cytochrome c
View Download 0.426 N/A N/A a.24.4 Hemerythrin
View Download 0.403 N/A N/A a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.401 N/A N/A a.22.1 Histone-fold
View Download 0.400 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.400 N/A N/A a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.390 N/A N/A a.22.1 Histone-fold
View Download 0.382 N/A N/A a.59.1 PAH2 domain
View Download 0.376 N/A N/A a.1.1 Globin-like
View Download 0.369 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.368 N/A N/A d.68.4 YhbY-like
View Download 0.365 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.365 N/A N/A a.7.8 GAT domain
View Download 0.360 N/A N/A a.19.1 Fertilization protein
View Download 0.353 N/A N/A a.74.1 Cyclin-like
View Download 0.344 N/A N/A a.42.1 MDM2
View Download 0.343 N/A N/A g.53.1 TAZ domain
View Download 0.325 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.322 N/A N/A a.74.1 Cyclin-like
View Download 0.322 N/A N/A a.26.1 4-helical cytokines
View Download 0.321 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.321 N/A N/A a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.317 N/A N/A a.2.7 tRNA-binding arm
View Download 0.308 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.307 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.303 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.298 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.293 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.292 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.291 N/A N/A a.47.2 t-snare proteins
View Download 0.290 N/A N/A a.24.3 Cytochromes
View Download 0.288 N/A N/A a.7.1 Spectrin repeat
View Download 0.282 N/A N/A d.58.13 Anticodon-binding domain of PheRS
View Download 0.275 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.275 N/A N/A a.47.2 t-snare proteins
View Download 0.274 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.271 N/A N/A a.118.1 ARM repeat
View Download 0.270 N/A N/A a.36.1 Signal peptide-binding domain
View Download 0.266 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.261 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.259 N/A N/A a.6.1 Putative DNA-binding domain
View Download 0.255 N/A N/A a.22.1 Histone-fold
View Download 0.253 N/A N/A a.4.1 Homeodomain-like
View Download 0.252 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.252 N/A N/A g.36.1 Ferredoxin thioredoxin reductase (FTR), catalytic beta chain
View Download 0.246 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.244 N/A N/A a.24.12 Outer surface protein C (OspC)
View Download 0.238 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.237 N/A N/A a.4.1 Homeodomain-like
View Download 0.237 N/A N/A d.202.1 Transcription factor NusA, N-terminal domain
View Download 0.236 N/A N/A d.94.1 HPr-like
View Download 0.232 N/A N/A d.79.1 YjgF-like
View Download 0.229 N/A N/A a.11.2 Second domain of FERM
View Download 0.228 N/A N/A d.58.27 Translational regulator protein regA
View Download 0.222 N/A N/A a.26.1 4-helical cytokines
View Download 0.218 N/A N/A a.38.1 Helix-loop-helix DNA-binding domain
View Download 0.217 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.216 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.215 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.214 N/A N/A a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.214 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.214 N/A N/A a.1.1 Globin-like
View Download 0.212 N/A N/A a.25.1 Ferritin-like
View Download 0.211 N/A N/A d.109.2 C-terminal, gelsolin-like domain of Sec23/24
View Download 0.211 N/A N/A d.58.16 Poly(A) polymerase, C-terminal domain
View Download 0.203 N/A N/A a.2.3 Chaperone J-domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle