YRC Public Data Repository - Protein Structure Prediction

Protein:	RTT101
Organism:	Saccharomyces cerevisiae
Length:	842 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RTT101.

Description	E-value	Query Range	Subject Range
CUL8_YEAST - Cullin-8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTT101 PE=1 SV=1 RTT101 - Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression;...	0.0	[1..842]	[1..842]
CUL1 - cullin 1 CUL1_PONPY - Cullin-1 - Pongo pygmaeus (Orangutan) CUL1_PONAB - Cullin-1 OS=Pongo abelii GN=CUL1 PE=2 SV=1 gi\|114616601, gi... - gi\|114616611\|ref\|XP_001165597.1\| PREDICTED: cullin 1 isoform 12 [Pan troglodytes], gi\|114616609\|ref\|...	0.0	[74..842]	[39..774]
gi\|224044991 - gi\|224044991\|ref\|XP_002198372.1\| PREDICTED: hypothetical protein [Taeniopygia guttata] gi\|363730292\|ref... - PREDICTED: cullin-1 [Gallus gallus] gi\|542154239\|ref... - PREDICTED: cullin-1 [Zonotrichia albicollis] CUL1_MOUSE - Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 gi\|62647154, gi\|... - gi\|62647154\|ref\|XP_342680.2\| PREDICTED: similar to Cullin-1 (CUL-1) [Rattus norvegicus], gi\|17184707...	0.0	[74..842]	[39..774]
gi\|19577357 - gi\|19577357\|emb\|CAD28438.1\| putative scf complex protein [Aspergillus fumigatus]	0.0	[58..839]	[2..743]
cul1 - cullin 1 CUL1_SCHPO - Cullin-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cul1 PE=1 SV=1	0.0	[74..842]	[44..765]
gi\|66801663, gi\|... - gi\|66801663\|ref\|XP_629756.1\| cullin [Dictyostelium discoideum AX4], gi\|60463149\|gb\|EAL61342.1\| culli... CUL1_DICDI - Cullin-1 OS=Dictyostelium discoideum GN=culA PE=1 SV=1	0.0	[76..842]	[41..768]
CUL1_ARATH - Cullin-1 OS=Arabidopsis thaliana GN=CUL1 PE=1 SV=1	0.0	[149..842]	[56..736]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[74..842]	[43..765]

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Predicted Domain #1

Region A:
Residues: [1-369]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINESVSKRE GFHESISRET SASNALGLYN KFNDERNPRY RTMIAELHEF FHLTLAETIT  60
   61 ETDVKELECN KEKAAKFRKL MPKMLNNCRE LTQRKSYIPY NSEFNGNDEK QKKFQLLHQH 120
  121 QIVLSFQEFC DELAKLIIDA HVLSFLTRCD YSYEIIPKNW TSFYKLFQYV MGAVGPIISY 180
  181 VPVNYPMIRK ELGFETLTIF QYYDSKLFEC MKSHFGREFS TLVSATIHHY IHMFPITNTM 240
  241 LEKEVPMLRI MSNCNFSIEG LSPKDFYMKT LRQYYCEESN LRPRLETFKN FKVLLTRNAL 300
  301 LASLFSPEWV SDANDLFISH LLLNKKSISE YIEIGKDTYD EEKERYFKTE THFSLLMFRN 360
  361 AFEAKNMLS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [383-396]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKAAYGSNHD TERL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1ldjA_
Description:	Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.44907471960058	bayes_pls_golite062009
transcription factor activity	3.48782936574155	bayes_pls_golite062009
ubiquitin-protein ligase activity	3.04993477724372	bayes_pls_golite062009
small conjugating protein ligase activity	3.01842842236076	bayes_pls_golite062009
transcription repressor activity	2.39237599101586	bayes_pls_golite062009
binding	2.3219000606044	bayes_pls_golite062009
acid-amino acid ligase activity	2.07503944671713	bayes_pls_golite062009
transcription activator activity	1.69071209162619	bayes_pls_golite062009
ligase activity	1.56500586430034	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.2152419300113	bayes_pls_golite062009
nucleic acid binding	1.19889127256113	bayes_pls_golite062009
protein binding	1.15192193279649	bayes_pls_golite062009
DNA binding	0.906045577633981	bayes_pls_golite062009
structure-specific DNA binding	0.851238175736283	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.602749768906734	bayes_pls_golite062009
catalytic activity	0.201606344181603	bayes_pls_golite062009
transcription factor binding	0.18566280876224	bayes_pls_golite062009
bubble DNA binding	0.163558276321259	bayes_pls_golite062009
specific transcriptional repressor activity	0.0565989703351002	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [370-382]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFKEFCDDAV SEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [397-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDEVVQLANV DHLKIYSDSI EYHLCNLLGS TSKAIEQYVK YFESHLFIIV RKIKTTKKDL  60
   61 PRDMKIKYLN ENLPILRLKF VNLPTFPNFF ERSIFRKTIL QSDQNSSFIK DILPVYKDSL 120
  121 MELFKQRIIT NVSQEDEMRY RDQYQPYLSQ FFQPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1ldjA_
Description:	Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [552-649]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVMADLRIKY ASFLSFYENI EAAVKFGKTY NENNSKSFFP LIFDRERIPK VFQQSNEVKK  60
   61 NFVLPQEMDD TWNQFLRNYH EQNKVEDSDA SKKELYPM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1ldjA_
Description:	Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [650-773]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNLHHCEVES PYIIQDGTNL IFELTLFQTC VLTLFNESDH LTLQVISEQT KLAYKDLALV  60
   61 LKSFCNYKIL TRDIDNTYSI NESFKPDMKK VKNGKLRVVL PRTASLQSSN TGGERTSSAH 120
  121 HEGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1ldjA_
Description:	Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [774-842]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSQWTQELLK ACITRSVKSE RNGLDYDHLF ETVKQQIKGF SVGEFKDALA KLLRDKFITR  60
   61 DESTATYKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	164.0
Match:	1ldjA_
Description:	Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: