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Protein Overview: CUL8_YEAST

General Information:
Name(s) found: CUL8_YEAST [Swiss-Prot]
Description(s) found:
  • Cullin-8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RTT101 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 842 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINESVSKRE GFHESISRET SASNALGLYN KFNDERNPRY RTMIAELHEF FHLTLAETIT  60
   61 ETDVKELECN KEKAAKFRKL MPKMLNNCRE LTQRKSYIPY NSEFNGNDEK QKKFQLLHQH 120
  121 QIVLSFQEFC DELAKLIIDA HVLSFLTRCD YSYEIIPKNW TSFYKLFQYV MGAVGPIISY 180
  181 VPVNYPMIRK ELGFETLTIF QYYDSKLFEC MKSHFGREFS TLVSATIHHY IHMFPITNTM 240
  241 LEKEVPMLRI MSNCNFSIEG LSPKDFYMKT LRQYYCEESN LRPRLETFKN FKVLLTRNAL 300
  301 LASLFSPEWV SDANDLFISH LLLNKKSISE YIEIGKDTYD EEKERYFKTE THFSLLMFRN 360
  361 AFEAKNMLSK FKEFCDDAVS EKLKAAYGSN HDTERLFDEV VQLANVDHLK IYSDSIEYHL 420
  421 CNLLGSTSKA IEQYVKYFES HLFIIVRKIK TTKKDLPRDM KIKYLNENLP ILRLKFVNLP 480
  481 TFPNFFERSI FRKTILQSDQ NSSFIKDILP VYKDSLMELF KQRIITNVSQ EDEMRYRDQY 540
  541 QPYLSQFFQP VEVMADLRIK YASFLSFYEN IEAAVKFGKT YNENNSKSFF PLIFDRERIP 600
  601 KVFQQSNEVK KNFVLPQEMD DTWNQFLRNY HEQNKVEDSD ASKKELYPMW NLHHCEVESP 660
  661 YIIQDGTNLI FELTLFQTCV LTLFNESDHL TLQVISEQTK LAYKDLALVL KSFCNYKILT 720
  721 RDIDNTYSIN ESFKPDMKKV KNGKLRVVLP RTASLQSSNT GGERTSSAHH EGSNSQWTQE 780
  781 LLKACITRSV KSERNGLDYD HLFETVKQQI KGFSVGEFKD ALAKLLRDKF ITRDESTATY 840
  841 KY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..369]
    [383..396]    		 PSI-BLAST 164.0 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    2 View Details [370..382]
    [397..551]    		 PSI-BLAST 164.0 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    3 View Details [552..649] PSI-BLAST 164.0 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    4 View Details [650..773] PSI-BLAST 164.0 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1
    5 View Details [774..842] PSI-BLAST 164.0 Anaphase promoting complex (APC); Cullin homolog 1, Cul-1; Cullin homolog 1, cul-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.44907471960058 bayes_pls_golite062009
  • transcription factor activity
    		•  3.48782936574155 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.04993477724372 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.01842842236076 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.39237599101586 bayes_pls_golite062009
  • binding
    		•  2.3219000606044 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.07503944671713 bayes_pls_golite062009
  • transcription activator activity
    		•  1.69071209162619 bayes_pls_golite062009
  • ligase activity
    		•  1.56500586430034 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.2152419300113 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.19889127256113 bayes_pls_golite062009
  • protein binding
    		•  1.15192193279649 bayes_pls_golite062009
  • DNA binding
    		•  0.906045577633981 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.851238175736283 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.602749768906734 bayes_pls_golite062009
  • catalytic activity
    		•  0.201606344181603 bayes_pls_golite062009
  • transcription factor binding
    		•  0.18566280876224 bayes_pls_golite062009
  • bubble DNA binding
    		•  0.163558276321259 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.0565989703351002 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle