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View Structure Prediction Details

Protein: CWC22
Organism: Saccharomyces cerevisiae
Length: 577 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CWC22.

Description E-value Query
Range
Subject
Range
CWC22_YEAST - Pre-mRNA-splicing factor CWC22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC22 PE=...
CWC22 - Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putat...
0.0 [1..577] [1..577]
gi|19528255 - gi|19528255|gb|AAL90242.1| GH13383p [Drosophila melanogaster]
0.0 [1..490] [399..912]
gi|10047283 - gi|10047283|dbj|BAB13430.1| KIAA1604 protein [Homo sapiens]
0.0 [1..492] [171..687]
gi|19113048 - gi|19113048|ref|NP_596256.1| hypothetical protein SPBC15D4.16 [Schizosaccharomyces pombe 972h-]
gi|3451474, gi|1... - gi|3451474|emb|CAA20491.1| SPBC13E7.01 [Schizosaccharomyces pombe], ref|NP_596256.1| conserved hypot...
0.0 [1..495] [103..618]
gi|6503305, gi|2... - gi|6503305|gb|AAF14681.1|AC011713_29 Contains similarity to gb|U19615 LET 858 gene from Caenorhabdit...
0.0 [1..494] [342..855]
let-858 - status:Confirmed UniProt:Q17336 protein_id:CAB04256.1
0.0 [1..480] [173..677]

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Predicted Domain #1
Region A:
Residues: [1-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTATIQDED IKFQRENWEM IRSHVSPIIS NLTMDNLQES HRDLFQVNIL IGRNIICKNV  60
   61 VDFTLNKQNG RLIPALSALI ALLNSDIPDI GETLAKELML MFVQQFNRKD YVSCGNILQC 120
  121 LSILFLYDVI HEIVILQILL LLLEKNSLRL VIAVMKICGW KLALVSKKTH DMIWEKLRYI 180
  181 LQTQELSSTL RESLETLFEI RQKDYKSGSQ GLFILDPTSY TVHTHS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.0
Match: 1hu3A_
Description: Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.20683443264388 bayes_pls_golite062009
mRNA binding 2.49094746544717 bayes_pls_golite062009
binding 2.47395644967726 bayes_pls_golite062009
nucleic acid binding 1.64539435934931 bayes_pls_golite062009
structural molecule activity 1.39201458088376 bayes_pls_golite062009
transcription regulator activity 1.06250847754412 bayes_pls_golite062009
protein binding 1.04044934052933 bayes_pls_golite062009
DNA binding 0.946847037737779 bayes_pls_golite062009
RNA cap binding 0.66277586901495 bayes_pls_golite062009
transcription factor activity 0.362911773502049 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [227-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIVSDEDEAN KELGNFEKCE NFNELTMAFD TLRQKLLINN TSDTNEGSNS QLQIYDMTST  60
   61 NDVEFKKKIY LVLK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
RNA binding 4.05046860305563 bayes_pls_golite062009
binding 2.36800795249393 bayes_pls_golite062009
mRNA binding 2.35042158577052 bayes_pls_golite062009
nucleic acid binding 1.59410102249793 bayes_pls_golite062009
structural molecule activity 1.3916221897201 bayes_pls_golite062009
transcription regulator activity 1.08645493064764 bayes_pls_golite062009
DNA binding 0.956143892328242 bayes_pls_golite062009
protein binding 0.914877292844892 bayes_pls_golite062009
transcription factor activity 0.371244009721798 bayes_pls_golite062009
RNA cap binding 0.357520253345298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [301-514]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLSGDEAAH KLLKLKIANN LKKSVVDIII KSSLQESTFS KFYSILSERM ITFHRSWQTA  60
   61 YNETFEQNYT QDIEDYETDQ LRILGKFWGH LISYEFLPMD CLKIIKLTEE ESCPQGRIFI 120
  121 KFLFQELVNE LGLDELQLRL NSSKLDGMFP LEGDAEHIRY SINFFTAIGL GLLTEDMRSR 180
  181 LTIIQEVEDA EEEEKKLREE EELEKLRKKA RESQ

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.46
Match: 1h6kA
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [515-577]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTQGPKIHES RLFLQKDTRE NSRSRSPFTV ETRKRARSRT PPRGSRNHRN RSRTPPARRQ  60
   61 RHR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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