YRC Public Data Repository - Protein Structure Prediction

Protein:	RBG2
Organism:	Saccharomyces cerevisiae
Length:	368 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RBG2.

Description	E-value	Query Range	Subject Range
DRG2_ARATH - Developmentally-regulated G-protein 2 OS=Arabidopsis thaliana GN=DRG2 PE=2 SV=1	6.0E-96	[1..368]	[1..367]
gi\|194198741, gi... - gi\|195569634\|ref\|XP_002102814.1\| GD20106 [Drosophila simulans], gi\|194198741\|gb\|EDX12317.1\| GD20106 ... gi\|220949542, gi... - gi\|220958466\|gb\|ACL91776.1\| CG6195-PA [synthetic construct], gi\|220949542\|gb\|ACL87314.1\| CG6195-PA [... gi\|195353604, gi... - gi\|195353604\|ref\|XP_002043294.1\| GM26898 [Drosophila sechellia], gi\|194127408\|gb\|EDW49451.1\| GM26898... CG6195-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6195 (CG6195, FBgn0038723). It is a protein...	4.0E-94	[1..368]	[1..363]
DRG2_MOUSE - Developmentally-regulated GTP-binding protein 2 OS=Mus musculus GN=Drg2 PE=1 SV=1 gi\|149052834 - gi\|149052834\|gb\|EDM04651.1\| rCG32787 [Rattus norvegicus]	2.0E-93	[1..368]	[1..364]
gi\|2654192 - gi\|2654192\|gb\|AAC33135.1\| GTP-binding protein [Oncorhynchus tshawytscha]	2.0E-93	[1..368]	[1..364]
RBG2_YEAST - Ribosome-interacting GTPase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RBG2 PE=1 ... gi\|151943451 - gi\|151943451\|gb\|EDN61762.1\| ribosome interacting GTPase [Saccharomyces cerevisiae YJM789] RBG2 - Protein with similarity to mammalian developmentally regulated GTP-binding protein gi\|190406811 - gi\|190406811\|gb\|EDV10078.1\| GTP-binding protein 1 [Saccharomyces cerevisiae RM11-1a]	2.0E-93	[1..368]	[1..368]
gi\|61359503, gi\|... - gi\|61359503\|gb\|AAX41728.1\| developmentally regulated GTP binding protein 2 [synthetic construct], gi... gi\|12653443, gi\|... - gi\|30582791\|gb\|AAP35622.1\| developmentally regulated GTP binding protein 2 [Homo sapiens], gi\|126534...	3.0E-93	[1..368]	[1..364]

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Predicted Domain #1

Region A:
Residues: [1-298]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIIDKIKAI EEEMARTQKN KATEHHLGLL KGKLARYRQQ LLADEAGSGG GGGSGFEVAK  60
   61 SGDARVVLIG YPSVGKSSLL GKITTTKSEI AHYAFTTLTS VPGVLKYQGA EIQIVDLPGI 120
  121 IYGASQGKGR GRQVVATART ADLVLMVLDA TKSEHQRASL EKELENVGIR LNKEKPNIYY 180
  181 KKKETGGVKV TFTSPPKTNL TEQAIKMILR DYRIHNAEVL VRDDQCTIDD FIDVINEQHR 240
  241 NYVKCLYVYN KIDAVSLEEV DKLAREPNTV VMSCEMDLGL QDVVEEIWYQ LNLSRVYT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.522879
Match:	1egaA_
Description:	GTPase Era, N-terminal domain; GTPase Era C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTP binding	3.12773729841136	bayes_pls_golite062009
guanyl ribonucleotide binding	3.11992469401001	bayes_pls_golite062009
guanyl nucleotide binding	3.11160667523268	bayes_pls_golite062009
binding	2.79149251200147	bayes_pls_golite062009
ribonucleotide binding	1.3103969098333	bayes_pls_golite062009
purine ribonucleotide binding	1.31038866506213	bayes_pls_golite062009
purine nucleotide binding	1.30205192849426	bayes_pls_golite062009
nucleotide binding	1.28752914655985	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [299-368]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRGVRPVFD DPLVVRNNST IGDLCHGIHR DFKDKFKYAL VWGSSAKHSP QKCGLNHRID  60
   61 DEDVVSLFAK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.09956015274464	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
guanyl nucleotide binding	1.89320355239381	bayes_pls_golite062009
guanyl ribonucleotide binding	1.88721318481223	bayes_pls_golite062009
GTP binding	1.87900088157196	bayes_pls_golite062009
DNA binding	1.87765278833074	bayes_pls_golite062009
GTPase activity	1.23010905798386	bayes_pls_golite062009
purine ribonucleotide binding	1.21658213854831	bayes_pls_golite062009
ribonucleotide binding	1.21652144153182	bayes_pls_golite062009
purine nucleotide binding	1.21571071905795	bayes_pls_golite062009
nucleotide binding	1.20347573865566	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
motor activity	0.926612891775441	bayes_pls_golite062009
transcription factor activity	0.682439846757997	bayes_pls_golite062009
cytoskeletal protein binding	0.498311726132348	bayes_pls_golite062009
pyrophosphatase activity	0.219555040684154	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.198256709027213	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.197994873032963	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
structural constituent of ribosome	0.089234257580272	bayes_pls_golite062009
helicase activity	0.0775311459068899	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: