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View Structure Prediction Details

Protein: ACT1
Organism: Saccharomyces cerevisiae
Length: 375 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ACT1.

Description E-value Query
Range
Subject
Range
ACTB_PONAB - Actin, cytoplasmic 1 OS=Pongo abelii GN=ACTB PE=2 SV=1
ACTB_CANLF - Actin, cytoplasmic 1 OS=Canis lupus familiaris GN=ACTB PE=2 SV=3
ACTB_BOVIN - Actin, cytoplasmic 1 OS=Bos taurus GN=ACTB PE=1 SV=1
gi|54695168 - gi|54695168|dbj|BAD67166.1| beta-actin [Meriones unguiculatus]
gi|149409094 - gi|149409094|ref|XP_001512727.1| PREDICTED: similar to tripartite motif-containing 37 protein [Ornit...
ACTB_PONPY - Actin, cytoplasmic 1 - Pongo pygmaeus (Orangutan)
gi|55250205, gi|... - gb|AAH86153.1| Unknown (protein for MGC:98584) [Xenopus laevis], gb|AAH86219.1| Unknown (protein fo...
gi|60686894 - gi|60686894|gb|AAX35537.1| beta-actin [Meleagris gallopavo]
ACTB_MOUSE - Actin, cytoplasmic 1 OS=Mus musculus GN=Actb PE=1 SV=1
ACTB_MESAU - Actin, cytoplasmic 1 OS=Mesocricetus auratus GN=ACTB PE=1 SV=1
gi|123980114, gi... - gi|60655869|gb|AAX32498.1| actin beta [synthetic construct], gi|168277960|dbj|BAG10958.1| actin, cyt...
ACTB_SPECI - Actin, cytoplasmic 1 OS=Spermophilus citellus GN=ACTB PE=2 SV=1
ACTB_MACFA - Actin, cytoplasmic 1 OS=Macaca fascicularis GN=ACTB PE=2 SV=1
gi|74316002 - gi|74316002|ref|NP_001028256.1| beta-actin [Macaca mulatta]
ACTB_SHEEP - Actin, cytoplasmic 1 OS=Ovis aries GN=ACTB PE=2 SV=1
ACTB_CHICK - Actin, cytoplasmic 1 OS=Gallus gallus GN=ACTB PE=1 SV=1
ACTB_CHLAE - Actin, cytoplasmic 1 OS=Chlorocebus aethiops GN=ACTB PE=2 SV=1
ACTB_RAT - Actin, cytoplasmic 1 OS=Rattus norvegicus GN=Actb PE=1 SV=1
ACTB_CAVPO - Actin, cytoplasmic 1 OS=Cavia porcellus GN=ACTB PE=2 SV=1
ENSCJAT00000000010 - null
ACTB_HORSE - Actin, cytoplasmic 1 OS=Equus caballus GN=ACTB PE=2 SV=1
gi|56342330|dbj|... - beta-actin [Pan troglodytes]
tr|G3GVD0|G3GVD0... - Actin, cytoplasmic 1 OS=Cricetulus griseus GN=I79_001666 PE=3 SV=1
ACTB_TRIVU - Actin, cytoplasmic 1 OS=Trichosurus vulpecula GN=ACTB PE=2 SV=1
ACTB_PANTR - Actin, cytoplasmic 1 OS=Pan troglodytes GN=ACTB PE=2 SV=1
ACTB - actin, beta
ACTB_PIG - Actin, cytoplasmic 1 OS=Sus scrofa GN=ACTB PE=1 SV=2
gi|126338082, gi... - gi|126338082|ref|XP_001362898.1| PREDICTED: similar to beta actin isoform 1 [Monodelphis domestica],...
gi|542157396|ref... - PREDICTED: actin, cytoplasmic 1 [Zonotrichia albicollis]
0.0 [1..375] [1..375]
gi|63018 - gi|63018|emb|CAA25004.1| beta-actin [Gallus gallus]
0.0 [1..375] [1..375]
ACTB_XENLA - Actin, cytoplasmic 1 OS=Xenopus laevis GN=actb PE=2 SV=1
0.0 [1..375] [1..375]
gi|309090 - gi|309090|gb|AAA37170.1| A-X actin
0.0 [1..375] [1..375]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..375] [1..375]
ACTB_CRIGR - Actin, cytoplasmic 1 OS=Cricetulus griseus GN=ACTB PE=3 SV=1
0.0 [1..375] [1..375]
ACTB_SIGHI - Actin, cytoplasmic 1 OS=Sigmodon hispidus GN=ACTB PE=2 SV=1
0.0 [1..375] [1..375]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSEVAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGIMVGMGQK DSYVGDEAQS  60
   61 KRGILTLRYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPM NPKSNREKMT 120
  121 QIMFETFNVP AFYVSIQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [339-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VWIGGSILAS LTTFQQMWIS KQEYDESGPS IVHHKCF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 2btfA_
Description: Actin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
lysine N-acetyltransferase activity 6.00435371802752 bayes_pls_golite062009
histone acetyltransferase activity 6.00435371802752 bayes_pls_golite062009
ATP-dependent 5'-3' DNA helicase activity 4.48403442393358 bayes_pls_golite062009
5'-3' DNA helicase activity 4.48403442393358 bayes_pls_golite062009
N-acetyltransferase activity 4.4623239863508 bayes_pls_golite062009
N-acyltransferase activity 4.17753709537507 bayes_pls_golite062009
acetyltransferase activity 3.85999832240402 bayes_pls_golite062009
actin binding 3.49917339467744 bayes_pls_golite062009
DNA helicase activity 3.48040623488385 bayes_pls_golite062009
acyltransferase activity 3.31611368687679 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.27955167799398 bayes_pls_golite062009
structural constituent of cytoskeleton 3.14961582364442 bayes_pls_golite062009
cytoskeletal protein binding 3.11425505645918 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.10494259200141 bayes_pls_golite062009
myosin binding 2.53108346927043 bayes_pls_golite062009
kinase activity 2.39470546929151 bayes_pls_golite062009
structural molecule activity 2.37892721989886 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.28750451001371 bayes_pls_golite062009
ADP binding 2.25399944386472 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
transcription regulator activity 2.09111975841662 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.06985477154666 bayes_pls_golite062009
actin filament binding 2.01821925799878 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
nucleic acid binding 1.84294882554466 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
DNA binding 1.70014394990425 bayes_pls_golite062009
transcription activator activity 1.35676801272576 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
transferase activity 1.25544026047211 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.19428728049016 bayes_pls_golite062009
transcription factor activity 1.06678984888387 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
DNA-dependent ATPase activity 0.866917783590327 bayes_pls_golite062009
glucose binding 0.81023419099138 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
protein transporter activity 0.780308299678282 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.574998559133169 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
protein kinase activity 0.344796257628435 bayes_pls_golite062009
nucleosome binding 0.329990231856661 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
glucuronosyltransferase activity 0.281824450653963 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.166787445046116 bayes_pls_golite062009
adenyl nucleotide binding 0.162883291947849 bayes_pls_golite062009
ATP binding 0.13613543261671 bayes_pls_golite062009
ligase activity 0.106704967795667 bayes_pls_golite062009
adenyl ribonucleotide binding 0.0977998908064818 bayes_pls_golite062009
chromatin binding 0.0489277194984092 bayes_pls_golite062009
unfolded protein binding 0.0304569608189402 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVLSLYSSGR TTGIVLDSGD GVTHVVPIYA GFSLPHAILR IDLAGRDLTD YLMKILSERG  60
   61 YSFSTTAERE IVRDIKEKLC YVALDFEQEM QTAAQSSSIE KSYELPDGQV ITIGNERFRA 120
  121 PEALFHPSVL GLESAGIDQT TYNSIMKCDV DVRKELYGNI VMSGGTTMFP GIAERMQKEI 180
  181 TALAPSSMKV KIIAPPERKY S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11000.0
Match: 2btfA_
Description: Actin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle