| Protein: | RPN3 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 523 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPN3.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..523] | [1..523] |
|
|
0.0 | [9..513] | [4..486] |
|
|
0.0 | [9..513] | [4..486] |
|
|
0.0 | [2..513] | [12..498] |
|
|
0.0 | [9..513] | [4..487] |
|
|
0.0 | [2..514] | [10..495] |
|
Region A: Residues: [1-109] |
1 11 21 31 41 51
| | | | | |
1 MASTAVMMDV DSSGVNDLHH SEKKYAEEDQ VQELLKVLNE ISKTTLTLDP RYIWRSLKDL 60
61 SSLRNQELLN AETLCFTVNV LYPDSSSFKK NLLKFITSNH KSSVPGSAE
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.771 | 0.062 | ubiquitin-dependent protein catabolic process | a.118.1 | ARM repeat |
| View | Download | 0.823 | 0.036 | ubiquitin-dependent protein catabolic process | a.118.8 | TPR-like |
| View | Download | 0.778 | 0.002 | ubiquitin-dependent protein catabolic process | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.700 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.667 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.660 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.602 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.601 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.600 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.582 | N/A | N/A | a.71.1 | Endoplasmic reticulum protein ERP29, C-domain |
| View | Download | 0.582 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.580 | N/A | N/A | a.118.11 | Cytochrome c oxidase subunit E |
| View | Download | 0.578 | N/A | N/A | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.575 | N/A | N/A | c.98.1 | MurE/MurF N-terminal domain |
| View | Download | 0.560 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.550 | N/A | N/A | c.78.2 | Aspartate/glutamate racemase |
| View | Download | 0.548 | N/A | N/A | a.165.1 | Myosin phosphatase inhibitor 17kDa protein, CPI-17 |
| View | Download | 0.535 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.517 | N/A | N/A | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.517 | N/A | N/A | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.516 | N/A | N/A | d.168.1 | Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain |
| View | Download | 0.516 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.510 | N/A | N/A | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.490 | N/A | N/A | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.488 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.486 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.482 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.481 | N/A | N/A | a.3.1 | Cytochrome c |
| View | Download | 0.479 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.465 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.456 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.455 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.452 | N/A | N/A | d.164.1 | SMAD MH1 domain |
| View | Download | 0.444 | N/A | N/A | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.440 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.425 | N/A | N/A | a.181.1 | Antibiotic binding domain of TipA-like multidrug resistance regulators |
| View | Download | 0.415 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.414 | N/A | N/A | a.118.13 | Arp2/3 complex 16 kDa subunit ARPC5 |
| View | Download | 0.410 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.409 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.393 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.383 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.377 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.375 | N/A | N/A | d.79.2 | Tubulin/Dihydroxyacetone kinase C-terminal domain |
| View | Download | 0.375 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.372 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.369 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.366 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.359 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.356 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.356 | N/A | N/A | a.5.4 | Elongation factor TFIIS domain 2 |
| View | Download | 0.354 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.352 | N/A | N/A | a.144.1 | PABC (PABP) domain |
| View | Download | 0.352 | N/A | N/A | e.37.1 | Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains |
| View | Download | 0.348 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.348 | N/A | N/A | d.8.1 | Urease, gamma-subunit |
| View | Download | 0.343 | N/A | N/A | c.55.4 | Translational machinery components |
| View | Download | 0.342 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.341 | N/A | N/A | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.341 | N/A | N/A | d.68.3 | SirA-like |
| View | Download | 0.339 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.338 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.337 | N/A | N/A | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.335 | N/A | N/A | c.47.1 | Thioredoxin-like |
| View | Download | 0.335 | N/A | N/A | a.165.1 | Myosin phosphatase inhibitor 17kDa protein, CPI-17 |
| View | Download | 0.332 | N/A | N/A | d.54.1 | Enolase N-terminal domain-like |
| View | Download | 0.332 | N/A | N/A | a.24.15 | FAD-dependent thiol oxidase |
| View | Download | 0.331 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.331 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.329 | N/A | N/A | a.3.1 | Cytochrome c |
| View | Download | 0.328 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.326 | N/A | N/A | a.5.4 | Elongation factor TFIIS domain 2 |
| View | Download | 0.323 | N/A | N/A | a.69.3 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain |
| View | Download | 0.321 | N/A | N/A | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.317 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.312 | N/A | N/A | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.312 | N/A | N/A | a.46.2 | Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain |
| View | Download | 0.312 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.311 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.311 | N/A | N/A | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.311 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.310 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.308 | N/A | N/A | c.95.1 | Thiolase-like |
| View | Download | 0.307 | N/A | N/A | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.301 | N/A | N/A | d.8.1 | Urease, gamma-subunit |
| View | Download | 0.300 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.300 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.298 | N/A | N/A | a.43.1 | Met repressor-like |
| View | Download | 0.298 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.297 | N/A | N/A | c.30.1 | PreATP-grasp domain |
| View | Download | 0.296 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.296 | N/A | N/A | c.37.1 | P-loop containing nucleoside triphosphate hydrolases |
| View | Download | 0.295 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.294 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.294 | N/A | N/A | a.181.1 | Antibiotic binding domain of TipA-like multidrug resistance regulators |
| View | Download | 0.294 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.291 | N/A | N/A | a.60.5 | Barrier-to-autointegration factor, BAF |
| View | Download | 0.290 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.288 | N/A | N/A | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.287 | N/A | N/A | a.41.1 | Domain of poly(ADP-ribose) polymerase |
| View | Download | 0.287 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.287 | N/A | N/A | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.283 | N/A | N/A | d.58.14 | Ribosomal protein S6 |
| View | Download | 0.283 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.279 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.277 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.276 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.272 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.271 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.270 | N/A | N/A | a.72.1 | Functional domain of the splicing factor Prp18 |
| View | Download | 0.269 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.268 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.267 | N/A | N/A | a.165.1 | Myosin phosphatase inhibitor 17kDa protein, CPI-17 |
| View | Download | 0.267 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.267 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.266 | N/A | N/A | a.23.2 | Diol dehydratase, gamma subunit |
| View | Download | 0.261 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.261 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.258 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.257 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.256 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.250 | N/A | N/A | a.79.1 | Antitermination factor NusB |
| View | Download | 0.250 | N/A | N/A | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.249 | N/A | N/A | a.60.2 | RuvA domain 2-like |
| View | Download | 0.249 | N/A | N/A | a.69.3 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, C-terminal domain |
| View | Download | 0.247 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.245 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.245 | N/A | N/A | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.243 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.237 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.235 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.235 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.233 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.232 | N/A | N/A | a.74.1 | Cyclin-like |
| View | Download | 0.229 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.229 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.228 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.227 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.227 | N/A | N/A | a.118.9 | ENTH/VHS domain |
| View | Download | 0.225 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.225 | N/A | N/A | a.59.1 | PAH2 domain |
| View | Download | 0.223 | N/A | N/A | c.102.1 | Cell-division inhibitor MinC, N-terminal domain |
| View | Download | 0.223 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.222 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.222 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.221 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.220 | N/A | N/A | a.77.1 | DEATH domain |
| View | Download | 0.219 | N/A | N/A | a.5.3 | N-terminal domain of phosphatidylinositol transfer protein sec14p |
| View | Download | 0.219 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.218 | N/A | N/A | a.91.1 | Regulator of G-protein signalling, RGS |
| View | Download | 0.218 | N/A | N/A | b.82.2 | Clavaminate synthase-like |
| View | Download | 0.217 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.215 | N/A | N/A | d.109.1 | Actin depolymerizing proteins |
| View | Download | 0.215 | N/A | N/A | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.213 | N/A | N/A | a.39.4 | Hypothetical protein MTH865 |
| View | Download | 0.211 | N/A | N/A | a.79.1 | Antitermination factor NusB |
| View | Download | 0.211 | N/A | N/A | a.41.1 | Domain of poly(ADP-ribose) polymerase |
| View | Download | 0.209 | N/A | N/A | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.208 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.206 | N/A | N/A | d.192.1 | YlxR-like |
| View | Download | 0.204 | N/A | N/A | a.73.1 | Retrovirus capsid protein, N-terminal core domain |
| View | Download | 0.203 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.201 | N/A | N/A | a.3.1 | Cytochrome c |
|
Region A: Residues: [110-315] |
1 11 21 31 41 51
| | | | | |
1 LRNSYPASFY SVNTEKKTIE VTAEINCFMH LLVQLFLWDS KELEQLVEFN RKVVIPNLLC 60
61 YYNLRSLNLI NAKLWFYIYL SHETLARSSE EINSDNQNII LRSTMMKFLK IASLKHDNET 120
121 KAMLINLILR DFLNNGEVDS ASDFISKLEY PHTDVSSSLE ARYFFYLSKI NAIQLDYSTA 180
181 NEYIIAAIRK APHNSKSLGF LQQSNK
|
| Detection Method: | |
| Confidence: | 10.38 |
| Match: | 1hz4A |
| Description: | Transcription factor MalT domain III |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| hydrolase activity | 2.802999698299 | bayes_pls_golite062009 |
| binding | 2.0556615145105 | bayes_pls_golite062009 |
| protein binding | 1.85124014295385 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.499034250223658 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.447205684237625 | bayes_pls_golite062009 |
| nucleic acid binding | 0.437277381081288 | bayes_pls_golite062009 |
| transcription regulator activity | 0.198767743012145 | bayes_pls_golite062009 |
| DNA binding | 0.186035324819401 | bayes_pls_golite062009 |
|
Region A: Residues: [316-447] |
1 11 21 31 41 51
| | | | | |
1 LHCCIQLLMG DIPELSFFHQ SNMQKSLLPY YHLTKAVKLG DLKKFTSTIT KYKQLLLKDD 60
61 TYQLCVRLRS NVIKTGIRII SLTYKKISLR DICLKLNLDS EQTVEYMVSR AIRDGVIEAK 120
121 INHEDGFIET TE
|
| Detection Method: | |
| Confidence: | 10.38 |
| Match: | 1hz4A |
| Description: | Transcription factor MalT domain III |
| Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 3.38230388954255 | bayes_pls_golite062009 |
| nucleic acid binding | 3.38144578566524 | bayes_pls_golite062009 |
| DNA binding | 3.30822066787723 | bayes_pls_golite062009 |
| binding | 2.93590311675477 | bayes_pls_golite062009 |
| transcription factor activity | 2.53517246325934 | bayes_pls_golite062009 |
| hydrolase activity | 2.30467124306022 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 1.28622713424902 | bayes_pls_golite062009 |
| protein binding | 1.09170941633583 | bayes_pls_golite062009 |
| transcription activator activity | 1.08566311616647 | bayes_pls_golite062009 |
| transcription repressor activity | 0.95491822926452 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.42135864069093 | bayes_pls_golite062009 |
| structural molecule activity | 0.272316540117209 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 0.136726704233672 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 0.118016217031359 | bayes_pls_golite062009 |
| structural constituent of ribosome | 0.0912115683429473 | bayes_pls_golite062009 |
|
Region A: Residues: [448-523] |
1 11 21 31 41 51
| | | | | |
1 LLNIYDSEDP QQVFDERIKF ANQLHDEYLV SMRYPEDKKT QQNEKSENGE NDDDTLDGDL 60
61 MDDMSDISDL DDLGFL
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.255 | a.77.1 | DEATH domain |
| View | Download | 0.246 | d.50.1 | dsRNA-binding domain-like |
| View | Download | 0.636 | a.59.1 | PAH2 domain |
| View | Download | 0.561 | a.165.1 | Myosin phosphatase inhibitor 17kDa protein, CPI-17 |
| View | Download | 0.446 | a.8.2 | Plasmid maintenance system epsilon/zeta, antidote epsilon subunit |
| View | Download | 0.228 | a.112.1 | Description not found. |
| View | Download | 0.226 | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.226 | a.77.1 | DEATH domain |
| View | Download | 0.225 | a.108.1 | Ribosomal protein L7/12, oligomerisation (N-terminal) domain |
| View | Download | 0.225 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.205 | a.6.1 | Putative DNA-binding domain |
