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View Structure Prediction Details

Protein: HYP2
Organism: Saccharomyces cerevisiae
Length: 157 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HYP2.

Description E-value Query
Range		 Subject
Range
ANB1 - Translation elongation factor eIF-5A, previously thought to function in translation initiation; simi...
gi|151945115 - gi|151945115|gb|EDN63366.1| translation initiation factor eIF5A [Saccharomyces cerevisiae YJM789]
gi|190409524 - gi|190409524|gb|EDV12789.1| translation initiation factor eIF-5A [Saccharomyces cerevisiae RM11-1a]
IF5A2_YEAST - Eukaryotic translation initiation factor 5A-2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288...
 9.0E-52 [1..157] [1..157]
IF5A3_ARATH - Eukaryotic translation initiation factor 5A-3 OS=Arabidopsis thaliana GN=ELF5A-3 PE=2 SV=1
 6.0E-50 [1..156] [1..158]
IF5A1_MOUSE - Eukaryotic translation initiation factor 5A-1 OS=Mus musculus GN=Eif5a PE=1 SV=2
gi|52745937|emb|... - unnamed protein product [Rattus sp.], unnamed protein product [Rattus sp.], unnamed protein product ...
gi|73955431, gi|... - gi|73955433|ref|XP_546586.2| PREDICTED: similar to eukaryotic translation initiation factor 5A isofo...
EIF5A - eukaryotic translation initiation factor 5A
gi|60552517, gi|... - gi|60552517|gb|AAH91629.1| LOC496181 protein [Xenopus laevis], gi|147899976|ref|NP_001088861.1| hypo...
IF5A1_RAT - Eukaryotic translation initiation factor 5A-1 OS=Rattus norvegicus GN=Eif5a PE=1 SV=3
gi|126309172 - gi|126309172|ref|XP_001365196.1| PREDICTED: similar to initiation factor 4D [Monodelphis domestica]
gi|149724243 - gi|149724243|ref|XP_001504816.1| PREDICTED: similar to initiation factor 4D [Equus caballus]
IF5A1_BOVIN - Eukaryotic translation initiation factor 5A-1 OS=Bos taurus GN=EIF5A PE=2 SV=3
gi|123997597, gi... - gi|123997597|gb|ABM86400.1| eukaryotic translation initiation factor 5A [synthetic construct], gi|12...
 3.0E-49 [1..151] [1..150]
IF5A1_SOLTU - Eukaryotic translation initiation factor 5A-1/2 OS=Solanum tuberosum GN=EIF5A1 PE=2 SV=1
 3.0E-49 [1..156] [1..159]
IF5A_NEUCR - Eukaryotic translation initiation factor 5A - Neurospora crassa
 4.0E-49 [2..157] [8..163]
IF5A1_SOLLC - Eukaryotic translation initiation factor 5A-1 OS=Solanum lycopersicum PE=2 SV=1
 4.0E-49 [1..156] [1..159]
IF5A2_NICPL - Eukaryotic translation initiation factor 5A-2 OS=Nicotiana plumbaginifolia GN=EIF-5A2 PE=2 SV=1
 4.0E-49 [1..156] [1..159]

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Predicted Domain #1
Region A:
Residues: [1-85] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEEHTFET ADAGSSATYP MQCSALRKNG FVVIKSRPCK IVDMSTSKTG KHGHAKVHLV  60
   61 AIDIFTGKKL EDLSPSTHNM EVPVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 590.156545
Match: 1fh4A_
Description: No description for 1fh4A_ was found.

Predicted functions:

Term Confidence Notes
U6 snRNA binding 7.69488393698619 bayes_pls_golite062009
structural constituent of ribosome 6.60650180781768 bayes_pls_golite062009
structural molecule activity 6.0174879876147 bayes_pls_golite062009
translation initiation factor activity 5.09596850944863 bayes_pls_golite062009
nucleic acid binding 3.89165617439497 bayes_pls_golite062009
translation elongation factor activity 3.58178742491041 bayes_pls_golite062009
DNA binding 3.38561002225202 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
RNA binding 1.76502371106766 bayes_pls_golite062009
sequence-specific DNA binding 1.74890841494748 bayes_pls_golite062009
transcription regulator activity 1.69669059514663 bayes_pls_golite062009
structure-specific DNA binding 1.54386990150255 bayes_pls_golite062009
translation regulator activity 1.46320772716954 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.40718318783582 bayes_pls_golite062009
single-stranded DNA binding 1.38349489974693 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
transcription activator activity 0.990244702925461 bayes_pls_golite062009
mRNA binding 0.883475899526061 bayes_pls_golite062009
transcription factor activity 0.859071050218437 bayes_pls_golite062009
telomeric DNA binding 0.594907498313479 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.474251377131502 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.47336621289748 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.47336621289748 bayes_pls_golite062009
RNA polymerase activity 0.39251242706379 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.39251242706379 bayes_pls_golite062009
ribonuclease activity 0.35186207828037 bayes_pls_golite062009
nuclease activity 0.26446253803519 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [86-157] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRNEYQLLDI DDGFLSLMNM DGDTKDDVKA PEGELGDSLQ TAFDEGKDLM VTIISAMGEE  60
   61 AAISFKEAAR TD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 590.156545
Match: 1fh4A_
Description: No description for 1fh4A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle