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View Structure Prediction Details

Protein: CYM1
Organism: Saccharomyces cerevisiae
Length: 989 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYM1.

Description E-value Query
Range
Subject
Range
gi|151942400 - gi|151942400|gb|EDN60756.1| metalloprotease [Saccharomyces cerevisiae YJM789]
gi|190404639 - gi|190404639|gb|EDV07906.1| metalloprotease [Saccharomyces cerevisiae RM11-1a]
CYM1 - Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin f...
CYM1_YEAST - Mitochondrial presequence protease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYM1 ...
0.0 [1..989] [1..989]
gi|13477137 - gi|13477137|gb|AAH05025.1| Pitrilysin metallopeptidase 1 [Homo sapiens]
0.0 [3..987] [24..1037]
PREP1_ARATH - Presequence protease 1, chloroplastic/mitochondrial OS=Arabidopsis thaliana GN=PREP1 PE=1 SV=2
0.0 [2..977] [71..1063]
gi|237803256, gi... - gi|237803256|ref|YP_002888450.1| metalloprotease-insulinase [Chlamydia trachomatis], gi|231274490|em...
gi|3329294, gi|1... - gi|3329294|gb|AAC68421.1| Zinc Metalloprotease (insulinase family) [Chlamydia trachomatis D/UW-3/CX]...
gi|7469080 - pir||A71466 probable zinc metalloproteinase (insulinase family) - Chlamydia trachomatis (serotype D,...
gi|76168099, gi|... - gi|76789569|ref|YP_328655.1| insulinase family metalloprotease [Chlamydia trachomatis A/HAR-13], gi|...
0.0 [21..972] [2..953]
gi|7190249, gi|1... - gi|7190249|gb|AAF39083.1| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi|15834831...
gi|7190249, gi|1... - gi|7190249|gb|AAF39083.1| metalloprotease, insulinase family [Chlamydia muridarum Nigg], gi|15834831...
0.0 [21..972] [2..953]
IDE_RAT - Insulin-degrading enzyme OS=Rattus norvegicus GN=Ide PE=1 SV=1
0.0 [14..966] [23..949]
IDE_MOUSE - Insulin-degrading enzyme OS=Mus musculus GN=Ide PE=1 SV=1
0.0 [8..966] [18..949]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRFQRFASS YAQAQAVRKY PVGGIFHGYE VRRILPVPEL RLTAVDLVHS QTGAEHLHID  60
   61 RDDKNNVFSI AFKTNPPDST GVPHILEHTT LCGSVKYPVR DPFFKMLNKS LANFMNAMTG 120
  121 PDYTFFPFST TNPQDFANLR GVYLDSTLNP LLKQEDFDQE GWRLEHKNIT DPESNIVFKG 180
  181 VVYNEMKGQI 

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [209-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNNSGGDPMK ITDLRYGDLL DFHHKNYHPS NAKTFTYGNL PLVDTLKQLN EQFSGYGKRA  60
   61 RKDKLLMPI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [413-447]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQKADFGLQL LYSILPGWTN KIDPFESLLF EDVLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.69897
Match: 1bccA_
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
metalloendopeptidase activity 3.72038852665442 bayes_pls_golite062009
endopeptidase activity 3.60100837479757 bayes_pls_golite062009
peptidase activity 3.59435865021473 bayes_pls_golite062009
metallopeptidase activity 3.51928093329287 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.00607833553933 bayes_pls_golite062009
hydrolase activity 2.42559068821325 bayes_pls_golite062009
catalytic activity 1.30647052031202 bayes_pls_golite062009
binding 0.820758410659358 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [191-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNANYYFWSK FQQSIYPS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [278-412]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLKKDIDVKL LGQIDTMLPP EKQTKASMTW ICGAPQDTYD TFLLKVLGNL LMDGHSSVMY  60
   61 QKLIESGIGL EFSVNSGVEP TTAVNLLTVG IQGVSDIEIF KDTVNNIFQN LLETEHPFDR 120
  121 KRIDAIIEQL ELSKK

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [448-532]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFRGDLETKG DTLFQDLIRK YIVHKPCFTF SIQGSEEFSK SLDDEEQTRL REKITALDEQ  60
   61 DKKNIFKRGI LLQEKQNEKE DLSCL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.69897
Match: 1bccA_
Description: Cytochrome bc1 core subunit 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [533-698]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLQIKDIPR AGDKYSIEQK NNTMSRITDT NGITYVRGKR LLNDIIPFEL FPYLPLFAES  60
   61 LTNLGTTTES FSEIEDQIKL HTGGISTHVE VTSDPNTTEP RLIFGFDGWS LNSKTDHIFE 120
  121 FWSKILLETD FHKNSDKLKV LIRLLASSNT SSVADAGHAF ARGYSA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [723-792]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHSLLDNEET FQREVVDKLT ELQKYIVDTN NMNFFITSDS DVQAKTVESQ ISKFMERLPH  60
   61 GSCLPNGPKT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1ezvB_
Description: Cytochrome bc1 core subunit 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [699-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AHYRSSGAIN ETLNGIEQLQ FINR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [793-916]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDYPLIGSKC KHTLIKFPFQ VHYTSQALLG VPYTHKDGSA LQVMSNMLTF KHLHREVREK  60
   61 GGAYGGGASY SALAGIFSFY SYRDPQPLKS LETFKNSGRY ILNDAKWGVT DLDEAKLTIF 120
  121 QQVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1ezvB_
Description: Cytochrome bc1 core subunit 2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [917-989]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APKSPKGEGV TYFMSGVTDD MKQARREQLL DVSLLDVHRV AEKYLLNKEG VSTVIGPGIE  60
   61 GKTVSPNWEV KEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle