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View Structure Prediction Details

Protein: GCD6
Organism: Saccharomyces cerevisiae
Length: 712 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCD6.

Description E-value Query
Range
Subject
Range
EI2BE_YEAST - Translation initiation factor eIF-2B subunit epsilon OS=Saccharomyces cerevisiae (strain ATCC 204508...
GCD6 - Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchang...
0.0 [1..704] [1..704]
gi|7488395, gi|3... - pir||T00478 probable translation regulator GCD6 F19I3.20 - Arabidopsis thaliana, gi|34098787|gb|AAQ...
0.0 [7..704] [5..714]
EI2BE_RAT, E2BE_RAT - (Q64350) Translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor), (Q64...
0.0 [2..711] [15..716]
EI2BE_RABIT - Translation initiation factor eIF-2B subunit epsilon OS=Oryctolagus cuniculus GN=EIF2B5 PE=1 SV=1
0.0 [2..701] [16..711]
tif225 - translation initiation factor eIF2B epsilon subunit
EI2BE_SCHPO - Probable translation initiation factor eIF-2B subunit epsilon OS=Schizosaccharomyces pombe (strain 9...
0.0 [14..703] [5..667]
EIF2B5 - eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
gi|123995989, gi... - gi|123995989|gb|ABM85596.1| eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa [s...
0.0 [65..701] [1..631]
gi|2832776 - gi|2832776|emb|CAA15932.1| EG:86E4.1 [Drosophila melanogaster]
0.0 [24..704] [6..659]

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Predicted Domain #1
Region A:
Residues: [1-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGKKGQKKS GLGNHGKNSD MDVEDRLQAV VLTDSYETRF MPLTAVKPRC LLPLANVPLI  60
   61 EYTLEFLAKA GVHEVFLICS SHANQINDYI ENSKWNLPWS PFKITTIMSP EARCTGDVMR 120
  121 DLDNRGIITG DFILVSGDVL TNIDFSKMLE FHKKMHLQDK DHISTMCLSK ASTYPKTRTI 180
  181 EPAAFVLDKS TSRCIYYQDL PLPSSREKTS IQIDPELLDN VDEFVIRNDL IDCRIDICTS 240
  241 HVPLIFQENF DYQSLRTDFV KGVISSDILG KHIYAYLTDE YAVRVESWQT YDTISQDFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 116.917458
Match: 1hv9A_
Description: N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uridylyltransferase activity 3.74072767898515 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 2.70047942699289 bayes_pls_golite062009
UTP:glucose-1-phosphate uridylyltransferase activity 2.65167602524122 bayes_pls_golite062009
UTP-monosaccharide-1-phosphate uridylyltransferase activity 2.46432078102948 bayes_pls_golite062009
UDP-glycosyltransferase activity 2.33861720107822 bayes_pls_golite062009
transferase activity 2.17535315350752 bayes_pls_golite062009
nucleotidyltransferase activity 2.00651267140641 bayes_pls_golite062009
catalytic activity 1.88676710996045 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.49149681135671 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 1.33788133706753 bayes_pls_golite062009
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity 1.17181714897181 bayes_pls_golite062009
polypeptide N-acetylgalactosaminyltransferase activity 1.10309252319727 bayes_pls_golite062009
binding 1.09657219604879 bayes_pls_golite062009
mannosyltransferase activity 0.91123217364068 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.897978517422275 bayes_pls_golite062009
acyltransferase activity 0.741838450922005 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 0.717805296858439 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.555398952276587 bayes_pls_golite062009
UDP-N-acetylglucosamine diphosphorylase activity 0.513376694534047 bayes_pls_golite062009
O-acyltransferase activity 0.319932817519902 bayes_pls_golite062009
mannose-phosphate guanylyltransferase activity 0.2363835251362 bayes_pls_golite062009
cytidylyltransferase activity 0.218759888732981 bayes_pls_golite062009
guanylyltransferase activity 0.0539392112504681 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [300-516]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRWCYPLVLD SNIQDDQTYS YESRHIYKEK DVVLAQSCKI GKCTAIGSGT KIGEGTKIEN  60
   61 SVIGRNCQIG ENIRIKNSFI WDDCIIGNNS IIDHSLIASN ATLGSNVRLN DGCIIGFNVK 120
  121 IDDNMDLDRN TKISASPLKN AGSRMYDNES NEQFDQDLDD QTLAVSIVGD KGVGYIYESE 180
  181 VSDDEDSSTE ACKEINTLSN QLDELYLSDD SISSATK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 116.917458
Match: 1hv9A_
Description: N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 9.37171190530754 bayes_pls_golite062009
translation regulator activity 5.35226950142169 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
RNA cap binding 1.73309326409609 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
structural molecule activity 0.908029258648777 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
mRNA binding 0.46864854653143 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [517-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTKKRRTMSV NSIYTDREEI DSEFEDEDFE KEGIATVERA MENNHDLDTA LLELNTLRMS  60
   61 MNVTYHEVRI ATITALLRRV YHFIATQTLG PKDAVVKVFN QWGLLFKRQA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [627-712]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDEEEYIDLM NIIMEKIVEQ SFDKPDLILF SALVSLYDND IIEEDVIYKW WDNVSTDPRY  60
   61 DEVKKLTVKW VEWLQNADEE SSSEEE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 27.60206
Match: PF02020
Description: eIF4-gamma/eIF5/eIF2-epsilon

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle