Protein Overview: tif225

General Information:
Name(s) found:	tif225 / SPAC8C9.15c [Sanger Pombe]
Description(s) found: Found 18 descriptions. SHOW ALL	translation initiation factor eIF2B epsilon subunit [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	678 amino acids
Gene Ontology:
Cellular Component:	cytosol [IDA] eukaryotic translation initiation factor 2B complex [ISS]
Biological Process:	positive regulation of translational initiation [IC] regulation of catalytic activity [IC] translational initiation [ISS]
Molecular Function:	translation initiation factor activity [ISS] nucleotidyltransferase activity [IEA] guanyl-nucleotide exchange factor activity [ISS] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSKGLNGK LEKPKHALQA IVLSDSYNYR FRPLTLDKPR CLLPLANTPL IEYTFEFLAL  60
   61 AGVQEVYVFC CAHAGQIREY IEKSKWNLPS SPFSVNTIVS RESLSVGDAL RELDSKQLIT 120
  121 SDFILVSGDV VSNVPLNEVL KEHRKRREDD KNAIMTMVVR EASPFHRTRA RTESSVFVID 180
  181 KKTSQCVHYQ ANERGKHYVS MDPEIFNEHE ELEVRNDLID CQIDICSNDV PALFTENFDY 240
  241 QDIRKDFVYG VLTSDLLGKK IHCHVAKENY AARVRSLQTY DAISKDVLSR WVYPFVPDSN 300
  301 LLNQTFSYQR HQIYKEEDVV LARSCIIKAR TLIGAYTKVG DASVVANTII GRNCTIGSNC 360
  361 SIDSAFLWED VVIGDNCRIG KAILANSVKI GNNCSIEDGA IVAAGVVIGD NTIIEKNKRL 420
  421 TTFESHSQGT LNDPSLVGIG GRGQEYHAEE DSDDEGEFME ASGLIESTNE LHLSDSESSE 480
  481 TSSSSEEDME FIPFSARRDS ANTINSEDFD EGDFNKEAQQ SLERAFEENH QIDIAALELN 540
  541 TLRMAMNANY HEVRSAIVLA LLRRIMHLDV SPKEALAKVM TRWGPLLAKL TFSHEEQVDN 600
  601 VLTLQKYCVR LSMTRHFLQL LGYFYQLEIA EENAIQEWYS DPRSSEGELA ALRDAGGKQF 660
  661 VDWLNTAESE SESEEGSE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..509]	PSI-BLAST	66.522879	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
2	View Details	[510..678]	PSI-BLAST	31.39794	CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF EUKARYOTIC INITIATION FACTOR 2B EPSILON

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transferase activity	2.17535315350752	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
nucleotidyltransferase activity	1.86990263440735	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.49149681135671	bayes_pls_golite062009
binding	1.09657219604879	bayes_pls_golite062009
protein binding	0.967722609820275	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	0.796949457473955	bayes_pls_golite062009
acyltransferase activity	0.741838450922005	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	0.717805296858439	bayes_pls_golite062009
UDP-glycosyltransferase activity	0.619458068514795	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.555398952276587	bayes_pls_golite062009
O-acyltransferase activity	0.319932817519902	bayes_pls_golite062009

2

Term	Confidence	Notes
translation initiation factor activity	9.37171190530754	bayes_pls_golite062009
translation regulator activity	5.35226950142169	bayes_pls_golite062009
structural molecule activity	4.37969512292045	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein binding	2.78733902345842	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
RNA cap binding	1.73309326409609	bayes_pls_golite062009
mRNA binding	1.71342954033223	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transcription activator activity	1.23830945970239	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
protein phosphatase binding	0.18767619609331	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle