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Protein Overview: tif225

General Information:
Name(s) found: tif225 / SPAC8C9.15c [Sanger Pombe]
Description(s) found:
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  • gi|7493510|pir||T39151 translation initiation factor eif-2b - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3023676|sp|P56287.1|EI2BE_SCHPO RecName: Full=Probable translation initiation factor eIF-2B subunit epsilon; AltName: Full=eIF-2B GDP-GTP exchange factor subunit epsilon [NCBI NR]
  • gi|2408098|emb|CAB16302.1| translation initiation factor eIF2B epsilon subunit [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115197|ref|NP_594285.1| translation initiation factor eIF2B epsilon subunit [Schizosaccharomyces pombe] [NCBI NR]
  • translation initiation factor eIF2B epsilon subunit [Sanger Pombe]
  • Probable translation initiation factor eIF-2B subunit epsilon OS=Schizosaccharomyces pombe GN=tif225 PE=1 SV=1 [Swiss-Prot]
  • (P56287) Probable translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor) [Swiss-Prot]
  • TRANSLATION INITIATION FACTOR EIF-2B: P56287; [pompepVF.fasta]
  • Probable translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor) [pompep4896]
  • |tif225||translation initiation factor eif-2b [pompepnew.fasta]
  • |tif225||translation initiation factor|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • translation initiation factor eif-2b [Schizosaccharomyces pombe]gi|2408098|emb|CAB16302.1| tif225 [Schizosaccharomyces pombe]gi|3023676|sp|P56287|E2BE_SCHPO Probable translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor)g [nrdb_11152004_Chlamydomonas]
  • |tif225||translation initiation factor eIF2B epsilon subunit|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC8C9.15c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC8C9.15c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Probable translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon) [nr-271106-contam.fasta]
  • |tif225||translation initiation factor eIF2B epsilon subunit |Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Probable translation initiation factor eIF-2B subunit epsilon OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tif225 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 678 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    eukaryotic translation initiation factor 2B complex [ISSLink to PubMed article]
    Biological Process: positive regulation of translational initiation [ICLink to PubMed article]
    regulation of catalytic activity [ICLink to PubMed article]
    translational initiation [ISSLink to PubMed article]
    Molecular Function: translation initiation factor activity [ISSLink to PubMed article]
    nucleotidyltransferase activity [IEA]
    guanyl-nucleotide exchange factor activity [ISSLink to PubMed article]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSKGLNGK LEKPKHALQA IVLSDSYNYR FRPLTLDKPR CLLPLANTPL IEYTFEFLAL  60
   61 AGVQEVYVFC CAHAGQIREY IEKSKWNLPS SPFSVNTIVS RESLSVGDAL RELDSKQLIT 120
  121 SDFILVSGDV VSNVPLNEVL KEHRKRREDD KNAIMTMVVR EASPFHRTRA RTESSVFVID 180
  181 KKTSQCVHYQ ANERGKHYVS MDPEIFNEHE ELEVRNDLID CQIDICSNDV PALFTENFDY 240
  241 QDIRKDFVYG VLTSDLLGKK IHCHVAKENY AARVRSLQTY DAISKDVLSR WVYPFVPDSN 300
  301 LLNQTFSYQR HQIYKEEDVV LARSCIIKAR TLIGAYTKVG DASVVANTII GRNCTIGSNC 360
  361 SIDSAFLWED VVIGDNCRIG KAILANSVKI GNNCSIEDGA IVAAGVVIGD NTIIEKNKRL 420
  421 TTFESHSQGT LNDPSLVGIG GRGQEYHAEE DSDDEGEFME ASGLIESTNE LHLSDSESSE 480
  481 TSSSSEEDME FIPFSARRDS ANTINSEDFD EGDFNKEAQQ SLERAFEENH QIDIAALELN 540
  541 TLRMAMNANY HEVRSAIVLA LLRRIMHLDV SPKEALAKVM TRWGPLLAKL TFSHEEQVDN 600
  601 VLTLQKYCVR LSMTRHFLQL LGYFYQLEIA EENAIQEWYS DPRSSEGELA ALRDAGGKQF 660
  661 VDWLNTAESE SESEEGSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..509] PSI-BLAST 66.522879 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
    2 View Details [510..678] PSI-BLAST 31.39794 CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF EUKARYOTIC INITIATION FACTOR 2B EPSILON

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transferase activity
    		•  2.17535315350752 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.86990263440735 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.49149681135671 bayes_pls_golite062009
  • binding
    		•  1.09657219604879 bayes_pls_golite062009
  • protein binding
    		•  0.967722609820275 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.796949457473955 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.741838450922005 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.717805296858439 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  0.619458068514795 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.555398952276587 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.319932817519902 bayes_pls_golite062009
    2
    Term Confidence Notes
  • translation initiation factor activity
    		•  9.37171190530754 bayes_pls_golite062009
  • translation regulator activity
    		•  5.35226950142169 bayes_pls_golite062009
  • structural molecule activity
    		•  4.37969512292045 bayes_pls_golite062009
  • binding
    		•  3.0667965351474 bayes_pls_golite062009
  • protein binding
    		•  2.78733902345842 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.34284977509828 bayes_pls_golite062009
  • RNA binding
    		•  1.98024495780436 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.76231475025891 bayes_pls_golite062009
  • RNA cap binding
    		•  1.73309326409609 bayes_pls_golite062009
  • mRNA binding
    		•  1.71342954033223 bayes_pls_golite062009
  • DNA binding
    		•  1.62032607987786 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23830945970239 bayes_pls_golite062009
  • transcription factor activity
    		•  0.923253759652909 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.803700928110921 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.18767619609331 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle