YRC Public Data Repository - Protein Structure Prediction

Protein:	tif225
Organism:	Schizosaccharomyces pombe
Length:	678 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif225.

Description	E-value	Query Range	Subject Range
EI2BE_RAT - Translation initiation factor eIF-2B subunit epsilon OS=Rattus norvegicus GN=Eif2b5 PE=1 SV=2 gi\|55741628 - ref\|NP_620221.2\| initiation factor eIF-2Be [Rattus norvegicus]	368.0	[0..10]	[675..30]
gi\|74003272 - gi\|74003272\|ref\|XP_545227.2\| PREDICTED: similar to Translation initiation factor eIF-2B epsilon subu...	347.0	[0..7]	[665..32]
EIF2B5 - eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	346.0	[0..11]	[665..36]
gi\|114590669 - gi\|114590669\|ref\|XP_001139517.1\| PREDICTED: eukaryotic translation initiation factor 2B, subunit 5 e...	346.0	[0..11]	[665..36]
EI2BE_RABIT - Translation initiation factor eIF-2B subunit epsilon OS=Oryctolagus cuniculus GN=EIF2B5 PE=1 SV=1	345.0	[0..11]	[665..36]
gi\|109042919 - gi\|109042919\|ref\|XP_001104122.1\| PREDICTED: eukaryotic translation initiation factor 2B, subunit 5 e...	342.0	[0..11]	[665..36]
EI2BE_MOUSE - Translation initiation factor eIF-2B subunit epsilon OS=Mus musculus GN=Eif2b5 PE=1 SV=1	339.0	[0..10]	[665..31]
EI2BE_YEAST - Translation initiation factor eIF-2B subunit epsilon OS=Saccharomyces cerevisiae (strain ATCC 204508... GCD6 - Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchang...	336.0	[0..15]	[668..24]

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Predicted Domain #1

Region A:
Residues: [1-509]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPSKGLNGK LEKPKHALQA IVLSDSYNYR FRPLTLDKPR CLLPLANTPL IEYTFEFLAL  60
   61 AGVQEVYVFC CAHAGQIREY IEKSKWNLPS SPFSVNTIVS RESLSVGDAL RELDSKQLIT 120
  121 SDFILVSGDV VSNVPLNEVL KEHRKRREDD KNAIMTMVVR EASPFHRTRA RTESSVFVID 180
  181 KKTSQCVHYQ ANERGKHYVS MDPEIFNEHE ELEVRNDLID CQIDICSNDV PALFTENFDY 240
  241 QDIRKDFVYG VLTSDLLGKK IHCHVAKENY AARVRSLQTY DAISKDVLSR WVYPFVPDSN 300
  301 LLNQTFSYQR HQIYKEEDVV LARSCIIKAR TLIGAYTKVG DASVVANTII GRNCTIGSNC 360
  361 SIDSAFLWED VVIGDNCRIG KAILANSVKI GNNCSIEDGA IVAAGVVIGD NTIIEKNKRL 420
  421 TTFESHSQGT LNDPSLVGIG GRGQEYHAEE DSDDEGEFME ASGLIESTNE LHLSDSESSE 480
  481 TSSSSEEDME FIPFSARRDS ANTINSEDF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	66.522879
Match:	1hv9A
Description:	N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transferase activity	2.17535315350752	bayes_pls_golite062009
catalytic activity	1.88676710996045	bayes_pls_golite062009
nucleotidyltransferase activity	1.86990263440735	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.49149681135671	bayes_pls_golite062009
binding	1.09657219604879	bayes_pls_golite062009
protein binding	0.967722609820275	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	0.796949457473955	bayes_pls_golite062009
acyltransferase activity	0.741838450922005	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	0.717805296858439	bayes_pls_golite062009
UDP-glycosyltransferase activity	0.619458068514795	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.555398952276587	bayes_pls_golite062009
O-acyltransferase activity	0.319932817519902	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [510-678]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEGDFNKEAQ QSLERAFEEN HQIDIAALEL NTLRMAMNAN YHEVRSAIVL ALLRRIMHLD  60
   61 VSPKEALAKV MTRWGPLLAK LTFSHEEQVD NVLTLQKYCV RLSMTRHFLQ LLGYFYQLEI 120
  121 AEENAIQEWY SDPRSSEGEL AALRDAGGKQ FVDWLNTAES ESESEEGSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.39794
Match:	1paqA
Description:	CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF EUKARYOTIC INITIATION FACTOR 2B EPSILON
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	9.37171190530754	bayes_pls_golite062009
translation regulator activity	5.35226950142169	bayes_pls_golite062009
structural molecule activity	4.37969512292045	bayes_pls_golite062009
binding	3.0667965351474	bayes_pls_golite062009
protein binding	2.78733902345842	bayes_pls_golite062009
nucleic acid binding	2.34284977509828	bayes_pls_golite062009
RNA binding	1.98024495780436	bayes_pls_golite062009
transcription regulator activity	1.76231475025891	bayes_pls_golite062009
RNA cap binding	1.73309326409609	bayes_pls_golite062009
mRNA binding	1.71342954033223	bayes_pls_golite062009
DNA binding	1.62032607987786	bayes_pls_golite062009
transcription activator activity	1.23830945970239	bayes_pls_golite062009
transcription factor activity	0.923253759652909	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.803700928110921	bayes_pls_golite062009
protein phosphatase binding	0.18767619609331	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: