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View Structure Prediction Details

Protein: CDC9
Organism: Saccharomyces cerevisiae
Length: 755 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC9.

Description E-value Query
Range
Subject
Range
gi|151941840 - gi|151941840|gb|EDN60196.1| DNA ligase [Saccharomyces cerevisiae YJM789]
DNLI1_YEAST - DNA ligase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC9 PE=1 SV=2
CDC9 - DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments d...
0.0 [1..755] [1..755]
DNLI1_SCHPO - DNA ligase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc17 PE=3 SV=1
cdc17 - ATP-dependent DNA ligase Cdc17
0.0 [18..750] [21..751]
DNLI1_ARATH - DNA ligase 1 OS=Arabidopsis thaliana GN=LIG1 PE=2 SV=2
0.0 [24..753] [48..779]
DNLI1_XENLA - DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1
0.0 [9..755] [305..1058]
LIG1 - ligase I, DNA, ATP-dependent
0.0 [10..755] [149..905]
DNLI1_MOUSE - DNA ligase 1 OS=Mus musculus GN=Lig1 PE=1 SV=2
0.0 [9..749] [146..897]
DNLI1_RAT - DNA ligase 1 OS=Rattus norvegicus GN=Lig1 PE=1 SV=1
0.0 [5..749] [150..899]
gi|16905197, gi|... - gi|40539108|gb|AAR87364.1| putative DNA ligase [Oryza sativa (japonica cultivar-group)], gi|37535574...
0.0 [8..751] [70..796]

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Predicted Domain #1
Region A:
Residues: [1-143]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRLLTGCLL SSARPLKSRL PLLMSSSLPS SAGKKPKQAT LARFFTSMKN KPTEGTPSPK  60
   61 KSSKHMLEDR MDNVSGEEEY ATKKLKQTAV THTVAAPSSM GSNFSSIPSS APSSGVADSP 120
  121 QQSQRLVGEV EDALSSNNND HYS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.99
Match: 1ldvA
Description: No description for 1ldvA was found.

Predicted Domain #2
Region A:
Residues: [144-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNIPYSEVCE VFNKIEAISS RLEIIRICSD FFIKIMKQSS KNLIPTTYLF INRLGPDYEA  60
   61 GLELGLGENL LMKTISETCG KSMSQIKLKY KDIGDLGEIA MGARNVQPTM FKPKPLTVGE 120
  121 VFKNLRAIAK TQGKDSQLKK MKLIKRMLTA CKGIEAKFLI RSLESKLRIG LAEKTVLISL 180
  181 SKALLLH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.17
Match: 1lshA
Description: Lipovitellin-phosvitin complex, superhelical domain; Lipovitellin-phosvitin complex; beta-sheet shell regions
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA ligase activity 5.12640522664474 bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds 5.0464977640909 bayes_pls_golite062009
DNA ligase (ATP) activity 3.18914513915107 bayes_pls_golite062009
DNA ligase (NAD+) activity 3.1488483282989 bayes_pls_golite062009
ligase activity 2.36807839237461 bayes_pls_golite062009
catalytic activity 2.15370807854636 bayes_pls_golite062009
nucleotidyltransferase activity 2.06695360101593 bayes_pls_golite062009
nucleic acid binding 1.4725380374617 bayes_pls_golite062009
binding 1.23714137231717 bayes_pls_golite062009
DNA binding 1.1855473374207 bayes_pls_golite062009
protein binding 0.0772495917382868 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [331-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DENREDSPDK DVPMDVLESA QQKIRDAFCQ VPNYEIVINS CLEHGIMNLD KYCTLRPGIP  60
   61 L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.502 a.4.1 Homeodomain-like
View Download 0.592 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.655 a.4.11 RNA polymerase subunit RPB10
View Download 0.730 a.5.6 Hypothetical protein MTH1615
View Download 0.447 d.54.1 Enolase N-terminal domain-like
View Download 0.387 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.353 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.353 a.112.1 Description not found.
View Download 0.333 a.4.1 Homeodomain-like
View Download 0.321 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.319 d.58.1 4Fe-4S ferredoxins
View Download 0.299 a.4.1 Homeodomain-like
View Download 0.296 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.295 a.159.2 FF domain
View Download 0.294 f.13.1 Family A G protein-coupled receptor-like
View Download 0.288 a.126.1 Serum albumin-like
View Download 0.259 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.240 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.239 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.236 d.120.1 Cytochrome b5
View Download 0.231 a.4.1 Homeodomain-like
View Download 0.220 d.15.2 CAD & PB1 domains
View Download 0.217 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.207 a.4.1 Homeodomain-like
View Download 0.205 a.64.2 Bacteriocin AS-48

Predicted Domain #4
Region A:
Residues: [392-419]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPMLAKPTKA INEVLDRFQG ETFTSEYK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [548-599]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQITTNNLDE LQKFLDESVN HSCEGLMVKM LEGPESHYEP SKRSRNWLKL KK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.30103
Match: 1a0i__
Description: ATP-dependent DNA ligase; ATP-dependent DNA ligase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [420-547]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDGERAQVHL LNDGTMRIYS RNGENMTERY PEINITDFIQ DLDTTKNLIL DCEAVAWDKD  60
   61 QGKILPFQVL STRKRKDVEL NDVKVKVCLF AFDILCYNDE RLINKSLKER REYLTKVTKV 120
  121 VPGEFQYA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [600-755]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYLEGVGDSL DLCVLGAYYG RGKRTGTYGG FLLGCYNQDT GEFETCCKIG TGFSDEMLQL  60
   61 LHDRLTPTII DGPKATFVFD SSAEPDVWFE PTTLFEVLTA DLSLSPIYKA GSATFDKGVS 120
  121 LRFPRFLRIR EDKGVEDATS SDQIVELYEN QSHMQN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.30103
Match: 1a0i__
Description: ATP-dependent DNA ligase; ATP-dependent DNA ligase, N-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle