YRC Public Data Repository - Protein Structure Prediction

Protein:	SIR2
Organism:	Saccharomyces cerevisiae
Length:	562 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SIR2.

Description	E-value	Query Range	Subject Range
SIR2_YEAST - NAD-dependent histone deacetylase SIR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S... SIR2 - Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespa... gi\|190405052 - gi\|190405052\|gb\|EDV08319.1\| NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae RM11-1a... gi\|207346927 - gi\|207346927\|gb\|EDZ73271.1\| YDL042Cp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..562]	[1..562]
SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70... SIR2_KLULA - NAD-dependent histone deacetylase SIR2 OS=Kluyveromyces lactis GN=SIR2 PE=3 SV=2	0.0	[99..554]	[142..610]
SIR2_CANAL - NAD-dependent histone deacetylase SIR2 OS=Candida albicans GN=SIR2 PE=3 SV=1	0.0	[123..553]	[91..506]
gi\|31982681, gi\|... - gi\|31982681\|ref\|NP_071877.2\| sirtuin 2 (silent mating type information regulation 2, homolog) 2 [Mus...	0.0	[178..553]	[11..361]
SIRT2 - sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) gi\|114677027 - gi\|114677027\|ref\|XP_001168375.1\| PREDICTED: sirtuin 2 isoform 8 [Pan troglodytes]	0.0	[178..553]	[11..361]

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Predicted Domain #1

Region A:
Residues: [1-191]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIPHMKYAV SKTSENKVSN TVSPTQDKDA IRKQPDDIIN NDEPSHKKIK VAQPDSLRET  60
   61 NTTDPLGHTK AALGEVASME LKPTNDMDPL AVSAASVVSM SNDVLKPETP KGPIIISKNP 120
  121 SNGIFYGPSF TKRESLNARM FLKYYGAHKF LDTYLPEDLN SLYIYYLIKL LGFEVKDQAL 180
  181 IGTINSIVHI N

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [192-273]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQERVQDLGS AISVTNVEDP LAKKQTVRLI KDLQRAINKV LCTRLRLSNF FTIDHFIQKL  60
   61 HTARKILVLT GAGVSTSLGI PD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [317-366]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPEKIYSPLH SFIKMLQMKG KLLRNYTQNI DNLESYAGIS TDKLVQCHGS

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [450-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNKFHKSIRE DILECDLLIC IGTSLKVAPV SEIVNMVPSH VPQVLINRDP VKHAEFDLSL  60
   61 LGYCDDIAAM VAQKCGWTIP HKKWNDLKNK NFKCQEKDKG VYVVTSDEHP KTL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	480.38764
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [274-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FRSSEGFYSK IKHLGLDDPQ DVFNYNIFMH DPSVFYNIAN MVL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [367-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FATATCVTCH WNLPGERIFN KIRNLELPLC PYCYKKRREY FPEGYNNKVG VAASQGSMSE  60
   61 RPPYILNSYG VLKPDITFFG EAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	480.38764
Match:	1j8fA_
Description:	Sirt2 histone deacetylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	11.8771442637949	bayes_pls_golite062009
histone deacetylase activity	11.7308825525122	bayes_pls_golite062009
deacetylase activity	10.8368006972109	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	8.53375308475286	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	8.13038616303736	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K9 specific)	7.45234027270448	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H3-K14 specific)	7.45234027270448	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	7.0185004322765	bayes_pls_golite062009
histone deacetylase activity (H3-K14 specific)	6.02509672218091	bayes_pls_golite062009
NAD-dependent histone deacetylase activity (H4-K16 specific)	5.11288441003953	bayes_pls_golite062009
tubulin deacetylase activity	4.98963898611597	bayes_pls_golite062009
histone deacetylase activity (H3-K9 specific)	4.84457718476539	bayes_pls_golite062009
NAD+ ADP-ribosyltransferase activity	4.62921662347995	bayes_pls_golite062009
transcription regulator activity	2.9155913558118	bayes_pls_golite062009
DNA binding	2.43141001866996	bayes_pls_golite062009
nucleic acid binding	2.41433477472968	bayes_pls_golite062009
transcription repressor activity	2.24657784428979	bayes_pls_golite062009
binding	2.06552694538163	bayes_pls_golite062009
NAD-independent histone deacetylase activity	2.03444106183496	bayes_pls_golite062009
histone binding	1.71445510915336	bayes_pls_golite062009
transcription corepressor activity	1.64212790017753	bayes_pls_golite062009
protein binding	1.52593340148652	bayes_pls_golite062009
nucleosome binding	1.5125174755597	bayes_pls_golite062009
hydrolase activity	1.43067365161346	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.40719303660557	bayes_pls_golite062009
transcription factor activity	1.30143289828088	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.26370407179255	bayes_pls_golite062009
transcription factor binding	1.14766678956419	bayes_pls_golite062009
NAD(P)+-protein-arginine ADP-ribosyltransferase activity	0.963519974868694	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.74741958699764	bayes_pls_golite062009
catalytic activity	0.739210399081789	bayes_pls_golite062009
cation transmembrane transporter activity	0.56434127203174	bayes_pls_golite062009
transcription cofactor activity	0.54005617175343	bayes_pls_golite062009
transferase activity	0.483523935618287	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: