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View Structure Prediction Details

Protein: PRP9
Organism: Saccharomyces cerevisiae
Length: 530 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PRP9.

Description E-value Query
Range
Subject
Range
PRP9 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the forma...
PRP9_YEAST - Pre-mRNA-splicing factor PRP9 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRP9 PE=1 ...
0.0 [1..530] [1..530]
gi|68533853, gi|... - gi|71043736|ref|NP_001020869.1| splicing factor 3a, subunit 3 [Rattus norvegicus], gi|68533853|gb|AA...
tr|G3HE04|G3HE04... - Splicing factor 3A subunit 3 OS=Cricetulus griseus GN=I79_008773 PE=4 SV=1
SF3A3_MOUSE - Splicing factor 3A subunit 3 OS=Mus musculus GN=Sf3a3 PE=1 SV=2
0.0 [2..530] [3..501]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [2..530] [3..501]
ENSCJAT00000004235 - null
gi|67969421 - gi|67969421|dbj|BAE01061.1| unnamed protein product [Macaca fascicularis]
SF3A3 - splicing factor 3a, subunit 3, 60kDa
gi|114555628 - gi|114555628|ref|XP_001170218.1| PREDICTED: splicing factor 3a, subunit 3 isoform 5 [Pan troglodytes...
gi|157928128, gi... - gi|208967488|dbj|BAG73758.1| splicing factor 3a, subunit 3, 60kDa [synthetic construct], gi|15792812...
0.0 [2..530] [3..501]
noi-PA - The gene noisette is referred to in FlyBase by the symbol Dmel\noi (CG2925, FBgn0014366). It is a pr...
gi|220944748 - gi|220944748|gb|ACL84917.1| noi-PA [synthetic construct]
0.0 [2..530] [3..503]
sap61 - U2 snRNP-associated protein sap61
SAP61_SCHPO - Pre-mRNA-splicing factor sap61 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sap61 PE=1 ...
0.0 [2..530] [4..492]
gi|19069179, gi|... - gi|19074537|ref|NP_586043.1| hypothetical protein ECU07_1140 [Encephalitozoon cuniculi GB-M1], gi|19...
gi|19074537 - ref|NP_586043.1| hypothetical protein [Encephalitozoon cuniculi]
1.0E-67 [157..530] [76..370]

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Predicted Domain #1
Region A:
Residues: [1-212]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLLETRRSL LEEMEIIENA IAERIQRNPE LYYHYIQESS KVFPDTKLPR SSLIAENKIY  60
   61 KFKKVKRKRK QIILQQHEIN IFLRDYQEKQ QTFNKINRPE ETQEDDKDLP NFERKLQQLE 120
  121 KELKNEDENF ELDINSKKDK YALFSSSSDP SRRTNILSDR ARDLDLNEIF TRDEQYGEYM 180
  181 ELEQFHSLWL NVIKRGDCSL LQFLDILELF LD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [213-530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEKYLLTPPM DRKNDRYMAF LLKLSKYVET FFFKSYALLD AAAVENLIKS DFEHSYCRGS  60
   61 LRSEAKGIYC PFCSRWFKTS SVFESHLVGK IHKKNESKRR NFVYSEYKLH RYLKYLNDEF 120
  121 SRTRSFVERK LAFTANERMA EMDILTQKYE APAYDSTEKE GAEQVDGEQR DGQLQEEHLS 180
  181 GKSFDMPLGP DGLPMPYWLY KLHGLDREYR CEICSNKVYN GRRTFERHFN EERHIYHLRC 240
  241 LGIEPSSVFK GITKIKEAQE LWKNMQGQSQ LTSIAAVPPK PNPSQLKVPT ELELEEEDEE 300
  301 GNVMSKKVYD ELKKQGLV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.37529385176635 bayes_pls_golite062009
DNA binding 3.3049326844117 bayes_pls_golite062009
nucleic acid binding 3.24981360535232 bayes_pls_golite062009
snRNA binding 3.16782731106334 bayes_pls_golite062009
RNA binding 3.11293528368816 bayes_pls_golite062009
U1 snRNA binding 2.86343975521155 bayes_pls_golite062009
transcription factor activity 2.44389510173662 bayes_pls_golite062009
binding 2.40458515823407 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.57041104288348 bayes_pls_golite062009
mRNA binding 1.28525296322454 bayes_pls_golite062009
transcription activator activity 1.20323819132961 bayes_pls_golite062009
sequence-specific DNA binding 0.732558534458316 bayes_pls_golite062009
protein binding 0.702841772031834 bayes_pls_golite062009
transcription repressor activity 0.686318575498149 bayes_pls_golite062009
chromatin binding 0.626365497850853 bayes_pls_golite062009
transcription factor binding 0.515821187939278 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.200483461579207 bayes_pls_golite062009
transcription cofactor activity 0.113925660147477 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle