YRC Public Data Repository - Protein Structure Prediction

Protein:	PCA1
Organism:	Saccharomyces cerevisiae
Length:	1216 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PCA1.

Description	E-value	Query Range	Subject Range
gi\|1272511 - gi\|1272511\|dbj\|BAA07831.1\| P-type ATPase [Saccharomyces cerevisiae]	0.0	[1..1216]	[17..1232]
gi\|18144214, gi\|... - gi\|18309537\|ref\|NP_561471.1\| copper-translocating P-type ATPase [Clostridium perfringens str. 13], g...	0.0	[320..1215]	[11..885]
COPA_STAAN - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain N315) GN=copA PE=1 SV=1 gi\|25290742 - pir\|\|F90060 copper-transporting ATPase copA copA [imported] - Staphylococcus aureus (strain N315) COPA_STAAM - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain Mu50 / ATCC 700699) GN=copA PE=3 S... COPA_STAA2 - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain JH1) GN=copA PE=3 SV=1 COPA_STAA1 - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain Mu3 / ATCC 700698) GN=copA PE=3 SV... COPA_STAA9 - Copper-exporting P-type ATPase A OS=Staphylococcus aureus (strain JH9) GN=copA PE=3 SV=1 gi\|253316059 - gi\|253316059\|ref\|ZP_04839272.1\| copper-transporting ATPase [Staphylococcus aureus subsp. aureus str.... gi\|255007329 - gi\|255007329\|ref\|ZP_05145930.2\| copper-transporting ATPase [Staphylococcus aureus subsp. aureus Mu50... gi\|269204190\|ref... - copper-translocating P-type ATPase [Staphylococcus aureus subsp. aureus ED98]	0.0	[409..1216]	[4..795]
gi\|15613120, gi\|... - gi\|15613120\|ref\|NP_241423.1\| copper-transporting ATPase [Bacillus halodurans C-125], gi\|10173170\|dbj... gi\|25290739 - pir\|\|E83719 copper-transporting ATPase BH0557 [imported] - Bacillus halodurans (strain C-125)	0.0	[409..1216]	[4..805]
gi\|1947035 - gi\|1947035\|gb\|AAB52902.1\| ATP7B [Homo sapiens]	0.0	[321..1193]	[363..1355]
COPA_BACSU - Copper-exporting P-type ATPase A OS=Bacillus subtilis GN=copA PE=1 SV=1 gi\|2635863, gi\|1... - gi\|2635863\|emb\|CAB15355.1\| yvgX [Bacillus subtilis subsp. subtilis str. 168], gi\|16080403\|ref\|NP_391...	0.0	[409..1215]	[5..803]

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Predicted Domain #1

Region A:
Residues: [1-313]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPEKLFSGL GTSDGEYGVV NSENISIDAM QDNRGECHRR SIEMHANDNL GLVSQRDCTN  60
   61 RPKITPQECL SETEQICHHG ENRTKAGLDV DDAETGGDHT NESRVDECCA EKVNDTETGL 120
  121 DVDSCCGDAQ TGGDHTNESC VDGCCVRDSS VMVEEVTGSC EAVSSKEQLL TSFEVVPSKS 180
  181 EGLQSIHDIR ETTRCNTNSN QHTGKGRLCI ESSDSTLKKR SCKVSRQKIE VSSKPECCNI 240
  241 SCVERIASRS CEKRTFKGST NVGISGSSST DSLSEKFFSE QYSRMYNRYS SILKNLGCIC 300
  301 NYLRTLGKES CCL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [314-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKVRFCSGEG ASKKTKYSYR NSSGCLTKKK THGDKERLSN DNGHADFVCS KSCCTKMKDC  60
   61 AVTSTISGTS SSEISR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.522879
Match:	1aw0__
Description:	Menkes copper-transporting ATPase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [390-456]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVSMEPIENH LNLEAGSTGT EHIVLSVSGM SCTGCESKLK KSFGALKCVH GLKTSLILSQ  60
   61 AEFNLDL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.629	0.050	cellular copper ion homeostasis	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.801	0.050	cellular copper ion homeostasis	d.58.5	GlnB-like
View	Download	0.667	0.050	cellular copper ion homeostasis	d.58.4	Dimeric alpha+beta barrel
View	Download	0.651	0.050	cellular copper ion homeostasis	d.43.1	Elongation factor Ts (EF-Ts), dimerisation domain
View	Download	0.643	0.050	cellular copper ion homeostasis	d.68.7	R3H domain
View	Download	0.623	0.050	cellular copper ion homeostasis	d.15.7	Immunoglobulin-binding domains
View	Download	0.619	0.050	cellular copper ion homeostasis	d.15.7	Immunoglobulin-binding domains
View	Download	0.586	0.050	cellular copper ion homeostasis	d.58.11	EF-G/eEF-2 domains III and V
View	Download	0.556	0.050	cellular copper ion homeostasis	d.64.1	eIF1-like
View	Download	0.547	0.050	cellular copper ion homeostasis	d.68.3	SirA-like
View	Download	0.536	0.050	cellular copper ion homeostasis	d.230.3	Amyloid beta a4 protein copper binding domain (domain 2)
View	Download	0.508	0.050	cellular copper ion homeostasis	c.52.2	tRNA splicing endonuclease, C-terminal domain
View	Download	0.506	0.050	cellular copper ion homeostasis	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.489	0.050	cellular copper ion homeostasis	d.68.1	Translation initiation factor IF3, C-terminal domain
View	Download	0.477	0.050	cellular copper ion homeostasis	g.59.1	Zinc-binding domain of translation initiation factor 2 beta
View	Download	0.469	0.050	cellular copper ion homeostasis	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.463	0.050	cellular copper ion homeostasis	d.58.12	eEF-1beta-like
View	Download	0.432	0.050	cellular copper ion homeostasis	d.95.2	Homing endonucleases
View	Download	0.430	0.050	cellular copper ion homeostasis	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.427	0.050	cellular copper ion homeostasis	d.68.5	C-terminal domain of ProRS
View	Download	0.418	0.050	cellular copper ion homeostasis	b.71.1	Glycosyl hydrolase domain
View	Download	0.418	0.050	cellular copper ion homeostasis	b.71.1	Glycosyl hydrolase domain
View	Download	0.393	0.050	cellular copper ion homeostasis	d.74.1	Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View	Download	0.377	0.050	cellular copper ion homeostasis	d.74.2	C-terminal domain of arginine repressor
View	Download	0.377	0.050	cellular copper ion homeostasis	d.58.3	Protease propeptides/inhibitors
View	Download	0.358	0.050	cellular copper ion homeostasis	g.18.1	Complement control module/SCR domain
View	Download	0.342	0.050	cellular copper ion homeostasis	d.58.12	eEF-1beta-like
View	Download	0.319	0.050	cellular copper ion homeostasis	b.43.4	Riboflavin synthase domain-like
View	Download	0.315	0.050	cellular copper ion homeostasis	d.74.3	RBP11-like subunits of RNA polymerase
View	Download	0.312	0.050	cellular copper ion homeostasis	d.58.7	RNA-binding domain, RBD
View	Download	0.306	0.050	cellular copper ion homeostasis	d.52.3	Prokaryotic type KH domain (KH-domain type II)
View	Download	0.300	0.050	cellular copper ion homeostasis	d.16.1	FAD-linked reductases, C-terminal domain
View	Download	0.299	0.050	cellular copper ion homeostasis	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.265	0.050	cellular copper ion homeostasis	b.71.1	Glycosyl hydrolase domain
View	Download	0.261	0.050	cellular copper ion homeostasis	d.58.44	Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View	Download	0.259	0.050	cellular copper ion homeostasis	b.24.1	Hyaluronate lyase-like, C-terminal domain
View	Download	0.253	0.050	cellular copper ion homeostasis	b.84.2	Rudiment single hybrid motif
View	Download	0.252	0.050	cellular copper ion homeostasis	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.252	0.050	cellular copper ion homeostasis	b.1.1	Immunoglobulin
View	Download	0.241	0.050	cellular copper ion homeostasis	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.239	0.050	cellular copper ion homeostasis	g.3.7	Scorpion toxin-like
View	Download	0.236	0.050	cellular copper ion homeostasis	d.58.7	RNA-binding domain, RBD
View	Download	0.235	0.050	cellular copper ion homeostasis	d.58.19	Bacterial exopeptidase dimerisation domain
View	Download	0.232	0.050	cellular copper ion homeostasis	d.74.3	RBP11-like subunits of RNA polymerase
View	Download	0.232	0.050	cellular copper ion homeostasis	d.58.10	Acylphosphatase-like
View	Download	0.231	0.050	cellular copper ion homeostasis	d.58.7	RNA-binding domain, RBD
View	Download	0.230	0.050	cellular copper ion homeostasis	d.52.4	YhbC-like, N-terminal domain
View	Download	0.230	0.050	cellular copper ion homeostasis	d.95.1	Glucose permease domain IIB
View	Download	0.228	0.050	cellular copper ion homeostasis	a.6.1	Putative DNA-binding domain
View	Download	0.222	0.050	cellular copper ion homeostasis	d.52.6	BolA-like
View	Download	0.222	0.050	cellular copper ion homeostasis	c.78.2	Aspartate/glutamate racemase
View	Download	0.221	0.050	cellular copper ion homeostasis	d.12.1	Ribosomal proteins L23 and L15e
View	Download	0.221	0.050	cellular copper ion homeostasis	d.58.7	RNA-binding domain, RBD
View	Download	0.216	0.050	cellular copper ion homeostasis	b.1.18	E set domains
View	Download	0.202	0.050	cellular copper ion homeostasis	d.52.5	Probable GTPase Der, C-terminal domain
View	Download	0.201	0.050	cellular copper ion homeostasis	d.16.1	FAD-linked reductases, C-terminal domain

Predicted Domain #4

Region A:
Residues: [457-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQGSVKDVIK HLSKTTEFKY EQISNHGSTI DVVVPYAAKD FINEEWPQGV TELKIVERNI  60
   61 IRIYFDPKVI GARDLVNEGW SVPVSIAPFS CHPTIEVGRK HLVRVG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.39794
Match:	1kqkA_
Description:	Potential copper-translocating P-type ATPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
copper chaperone activity	9.82063669832995	bayes_pls_golite062009
copper-dependent protein binding	9.4886676850819	bayes_pls_golite062009
metallochaperone activity	8.74818422646376	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	7.67724993505658	bayes_pls_golite062009
copper ion transmembrane transporter activity	6.91184156399207	bayes_pls_golite062009
copper ion binding	5.41725082570189	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.4007166857771	bayes_pls_golite062009
copper-exporting ATPase activity	5.04749761961029	bayes_pls_golite062009
copper-transporting ATPase activity	5.03252922496602	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	4.79570221435856	bayes_pls_golite062009
cation transmembrane transporter activity	4.61622753861072	bayes_pls_golite062009
ion transmembrane transporter activity	4.52484959112186	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.12792340516867	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.10264569844449	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	3.70964017127302	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.27250923701445	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.98847682261773	bayes_pls_golite062009
metal ion binding	2.69806984896689	bayes_pls_golite062009
cation binding	2.69806984896689	bayes_pls_golite062009
ion binding	2.69078950610234	bayes_pls_golite062009
transition metal ion binding	2.52520930681159	bayes_pls_golite062009
transporter activity	2.43435890488191	bayes_pls_golite062009
transmembrane transporter activity	2.32163502360862	bayes_pls_golite062009
binding	2.31155280022787	bayes_pls_golite062009
substrate-specific transporter activity	2.28845421748925	bayes_pls_golite062009
primary active transmembrane transporter activity	1.62116507842838	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.61680623728503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.59572740343301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.5925429451548	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.59219836319916	bayes_pls_golite062009
active transmembrane transporter activity	1.53883152283038	bayes_pls_golite062009
hydrolase activity	1.26149508477113	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.1718859439419	bayes_pls_golite062009
pyrophosphatase activity	1.10705671028492	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.09044745388495	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.0880789970261	bayes_pls_golite062009
ATPase activity	1.08091411328281	bayes_pls_golite062009
ATPase activity, coupled	1.02520458852568	bayes_pls_golite062009
protein binding	0.889287086236279	bayes_pls_golite062009
cation-transporting ATPase activity	0.75722873989123	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [563-607]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CTTALSIILT IPILVMAWAP QLREKISTIS ASMVLATIIQ FVIAG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [696-796]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAILVDKTGK ETEINIRLLQ YGDIFKVLPD SRIPTDGTVI SGSSEVDEAL ITGESMPVPK  60
   61 KCQSIVVAGS VNGTGTLFVK LSKLPGNNTI STIATMVDEA K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.529817
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted functions:

Term	Confidence	Notes
copper chaperone activity	9.82063669832995	bayes_pls_golite062009
copper-dependent protein binding	9.4886676850819	bayes_pls_golite062009
metallochaperone activity	8.74818422646376	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	7.67724993505658	bayes_pls_golite062009
copper ion transmembrane transporter activity	6.91184156399207	bayes_pls_golite062009
copper ion binding	5.41725082570189	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.4007166857771	bayes_pls_golite062009
copper-exporting ATPase activity	5.04749761961029	bayes_pls_golite062009
copper-transporting ATPase activity	5.03252922496602	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	4.79570221435856	bayes_pls_golite062009
cation transmembrane transporter activity	4.61622753861072	bayes_pls_golite062009
ion transmembrane transporter activity	4.52484959112186	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.12792340516867	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.10264569844449	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	3.70964017127302	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.27250923701445	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.98847682261773	bayes_pls_golite062009
metal ion binding	2.69806984896689	bayes_pls_golite062009
cation binding	2.69806984896689	bayes_pls_golite062009
ion binding	2.69078950610234	bayes_pls_golite062009
transition metal ion binding	2.52520930681159	bayes_pls_golite062009
transporter activity	2.43435890488191	bayes_pls_golite062009
transmembrane transporter activity	2.32163502360862	bayes_pls_golite062009
binding	2.31155280022787	bayes_pls_golite062009
substrate-specific transporter activity	2.28845421748925	bayes_pls_golite062009
primary active transmembrane transporter activity	1.62116507842838	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.61680623728503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.59572740343301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.5925429451548	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.59219836319916	bayes_pls_golite062009
active transmembrane transporter activity	1.53883152283038	bayes_pls_golite062009
hydrolase activity	1.26149508477113	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.1718859439419	bayes_pls_golite062009
pyrophosphatase activity	1.10705671028492	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.09044745388495	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.0880789970261	bayes_pls_golite062009
ATPase activity	1.08091411328281	bayes_pls_golite062009
ATPase activity, coupled	1.02520458852568	bayes_pls_golite062009
protein binding	0.889287086236279	bayes_pls_golite062009
cation-transporting ATPase activity	0.75722873989123	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [608-685]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFYLNALKSL IFSRLIEMDL LIVLSTSAAY IFSIVSFGYF VVGRPLSTEQ FFETSSLLVT  60
   61 LIMVGRFVSE LARHRAVK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [797-870]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTKPKIQNIA DKIASYFVPT IIGITVVTFC VWIAVGIRVE KQSRSDAVIQ AIIYAITVLI  60
   61 VSCPCVIGLA VPIV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.529817
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #7

Region A:
Residues: [686-695]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SISVRSLQAS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [871-937]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVIASGVAAK RGVIFKSAES IEVAHNTSHV VFDKTGTLTE GKLTVVHETV RGDRHNSQSL  60
   61 LLGLTEG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	125.529817
Match:	1eulA_
Description:	Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #8

Region A:
Residues: [938-1001]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKHPVSMAIA SYLKEKGVSA QNVSNTKAVT GKRVEGTSYS GLKLQGGNCR WLGHNNDPDV  60
   61 RKAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.39794
Match:	1f5sA_
Description:	Phosphoserine phosphatase
Matching Structure (courtesy of the PDB):

Predicted Domain #9

Region A:
Residues: [1002-1154]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EQGYSVFCFS VNGSVTAVYA LEDSLRADAV STINLLRQRG ISLHILSGDD DGAVRSMAAR  60
   61 LGIESSNIRS HATPAEKSEY IKDIVEGRNC DSSSQSKRPV VVFCGDGTND AIGLTQATIG 120
  121 VHINEGSEVA KLAADVVMLK PKLNNILTMI TVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.39794
Match:	1f5sA_
Description:	Phosphoserine phosphatase
Matching Structure (courtesy of the PDB):

Predicted Domain #10

Region A:
Residues: [1155-1216]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKAMFRVKLN FLWSFTYNLF AILLAAGAFV DFHIPPEYAG LGELVSILPV IFVAILLRYA  60
   61 KI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: