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View Structure Prediction Details

Protein: DNM1
Organism: Homo sapiens
Length: 864 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNM1.

Description E-value Query
Range
Subject
Range
gi|123230375, gi... - gi|123230375|emb|CAM15853.1| dynamin 1 [Mus musculus], gi|116063570|ref|NP_034195.2| dynamin [Mus mu...
0.0 [1..860] [1..856]
DNM1 - dynamin 1
0.0 [1..850] [1..850]
DYN1_BOVIN - Dynamin-1 OS=Bos taurus GN=DNM1 PE=2 SV=1
0.0 [1..856] [1..856]

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Predicted Domain #1
Region A:
Residues: [1-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNRGMEDLI PLVNRLQDAF SAIGQNADLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG  60
   61 SGIVTRRPLV LQLVNATTEY AEFLHCKGKK FTDFEEVRLE IEAETDRVTG TNKGISPVPI 120
  121 NLRVYSPHVL NLTLVDLPGM TKVPVGDQPP DIEFQIRDML MQFVTKENCL ILAVSPANSD 180
  181 LANSDALKVA KEVDPQGQRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK 240
  241 DIDGKKDITA ALAAERKFFL SHPSYRHLAD RMGTPYLQKV LNQQLTNHIR DTLPGLRNKL 300
  301 QSQLLSIEKE VEEYKNFR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 136.0
Match: 2akaB
Description: Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [319-512]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDDPARKTKA LLQMVQQFAV DFEKRIEGSG DQIDTYELSG GARINRIFHE RFPFELVKME  60
   61 FDEKELRREI SYAIKNIHGI RTGLFTPDMA FETIVKKQVK KIREPCLKCV DMVISELIST 120
  121 VRQCTKKLQQ YPRLREEMER IVTTHIRERE GRTKEQVMLL IDIELAYMNT NHEDFIGFAN 180
  181 AQQRSNQMNK KKTS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [513-631]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNQDEILVIR KGWLTINNIG IMKGGSKEYW FVLTAENLSW YKDDEEKEKK YMLSVDNLKL  60
   61 RDVEKGFMSS KHIFALFNTE QRNVYKDYRQ LELACETQEE VDSWKASFLR AGVYPERVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 2dynA
Description: Dynamin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.72754591832642 bayes_pls_golite062009
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
actin filament binding 2.03444575838575 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
glutamate receptor binding 1.76346239890943 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
nucleic acid binding 1.55295906221034 bayes_pls_golite062009
clathrin binding 1.29927347270153 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
substrate-specific transporter activity 0.79883446648737 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
profilin binding 0.66906205737225 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
receptor activity 0.353510125274044 bayes_pls_golite062009
beta-amyloid binding 0.34714857141225 bayes_pls_golite062009
transmembrane receptor activity 0.207829786337892 bayes_pls_golite062009
structural molecule activity 0.160152014803717 bayes_pls_golite062009
protein complex binding 0.15504114076075 bayes_pls_golite062009
alpha-catenin binding 0.102004310679969 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [632-744]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKEKASETEE NGSDSFMHSM DPQLERQVET IRNLVDSYMA IVNKTVRDLM PKTIMHLMIN  60
   61 NTKEFIFSEL LANLYSCGDQ NTLMEESAEQ AQRRDEMLRM YHALKEALSI IGD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 28.769551
Match: PF02212.9
Description: No description for PF02212.9 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.953 0.002 GTPase activity a.7.4 Smac/diablo

Predicted Domain #5
Region A:
Residues: [745-864]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INTTTVSTPM PPPVDDSWLQ VQSVPAGRRS PTSSPTPQRR APAVPPARPG SRGPAPGPPP  60
   61 AGSALGGAPP VPSRPGASPD PFGPPPQVPS RPNRAPPGVP SRSGQASPSR PESPRPPFDL 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1y0fA
Description: No description for 1y0fA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle