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View Structure Prediction Details

Protein: gi|60655777, gi|...
Organism: synthetic construct
Length: 382 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|60655777, gi|....

Description E-value Query
Range		 Subject
Range
gi|30585317, gi|... - gi|60652683|gb|AAX29036.1| protein kinase cAMP-dependent regulatory type II, alpha [synthetic constr...
 2.0E-73 [1..382] [1..382]
PRKAR2A - protein kinase, cAMP-dependent, regulatory, type II, alpha
gi|208967188 - gi|208967188|dbj|BAG73608.1| protein kinase, cAMP-dependent, regulatory, type II alpha [synthetic co...
 3.0E-70 [1..382] [1..404]
gi|22506903, gi|... - gi|74210084|dbj|BAE21323.1| unnamed protein product [Mus musculus], gi|51329857|gb|AAH80276.1| Prote...
 1.0E-67 [1..382] [1..402]
gi|73985628 - gi|73985628|ref|XP_863227.1| PREDICTED: similar to cAMP-dependent protein kinase type II-alpha regul...
 7.0E-67 [1..382] [1..379]
KAP2_RAT - cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Rattus norvegicus GN=Prkar2a PE=1 ...
 5.0E-66 [1..382] [1..401]
KAP2_BOVIN - cAMP-dependent protein kinase type II-alpha regulatory subunit - Bos taurus (Bovine)
 1.0E-65 [2..382] [1..400]

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Predicted Domain #1
Region A:
Residues: [1-70] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG  60
   61 HPPPEPGPDR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.870 0.010 cAMP-dependent protein kinase regulator activity a.5.6 Hypothetical protein MTH1615

Predicted Domain #2
Region A:
Residues: [71-382] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH PKTDEQRCRL  60
   61 QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE RGTYDILVTK 120
  121 DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI IVKNNAKKRK 180
  181 MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QTKSNKDGGN QEVEIARCHK 240
  241 GQYFGELALV TNKPRAASAY AVGDVKCLVM DVQAFERLLG PCMDIMKRNI SHYEEQLVKM 300
  301 FGSSVDLGNL GQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 1cx4A
Description: Regulatory subunit of Protein kinase A
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
gated channel activity 3.75615867846417 bayes_pls_golite062009
ligand-gated ion channel activity 3.71111882888041 bayes_pls_golite062009
ligand-gated channel activity 3.71111882888041 bayes_pls_golite062009
cation channel activity 3.61025292543387 bayes_pls_golite062009
ion channel activity 3.49583875363169 bayes_pls_golite062009
substrate-specific channel activity 2.99565487349638 bayes_pls_golite062009
transporter activity 2.8998330876169 bayes_pls_golite062009
transmembrane transporter activity 2.85192191539872 bayes_pls_golite062009
cAMP-dependent protein kinase regulator activity 2.78017841119787 bayes_pls_golite062009
substrate-specific transporter activity 2.66890994787635 bayes_pls_golite062009
passive transmembrane transporter activity 2.66781824266082 bayes_pls_golite062009
channel activity 2.66781824266082 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.64973131242976 bayes_pls_golite062009
ion transmembrane transporter activity 2.62037413430064 bayes_pls_golite062009
cation transmembrane transporter activity 2.28218867890883 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.24699267672716 bayes_pls_golite062009
transcription regulator activity 1.97137082688083 bayes_pls_golite062009
binding 1.80151718402565 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 1.68618484766279 bayes_pls_golite062009
nucleic acid binding 1.62633054482127 bayes_pls_golite062009
DNA binding 1.54942974151543 bayes_pls_golite062009
enzyme regulator activity 1.40720858109605 bayes_pls_golite062009
molecular transducer activity 1.29733029674587 bayes_pls_golite062009
signal transducer activity 1.29733029674587 bayes_pls_golite062009
cyclic nucleotide-gated ion channel activity 1.26984296847489 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 1.26984296847489 bayes_pls_golite062009
transcription factor activity 1.14697837766975 bayes_pls_golite062009
kinase regulator activity 0.944734749939467 bayes_pls_golite062009
GTPase regulator activity 0.930640481652164 bayes_pls_golite062009
protein kinase regulator activity 0.921648634540942 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.910527807644534 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.848189810874263 bayes_pls_golite062009
protein binding 0.81302068072988 bayes_pls_golite062009
nucleotide binding 0.274529576258456 bayes_pls_golite062009
voltage-gated ion channel activity 0.26553997342843 bayes_pls_golite062009
voltage-gated channel activity 0.26063388960068 bayes_pls_golite062009
ribonucleotide binding 0.0296966221249605 bayes_pls_golite062009
purine ribonucleotide binding 0.0295376254112757 bayes_pls_golite062009
purine nucleotide binding 0.025744194913981 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle