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Protein Overview: PRKAR2A

General Information:
Name(s) found: PRKAR2A [HGNC (HUGO)]
Description(s) found:
Found 33 descriptions.
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  • protein kinase, cAMP-dependent, regulatory, type II, alpha [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 404 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG  60
   61 HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH 120
  121 PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE 180
  181 RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI 240
  241 IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI 300
  301 IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL 360
  361 VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 23.045757 Regulatory domain of epac2, domain 2; Regulatory domain of Epac2, domains 1 and 3
    2 View Details [87..404] PSI-BLAST 48.39794 Regulatory subunit of Protein kinase A

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • gated channel activity
    		•  3.75615867846417 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.71111882888041 bayes_pls_golite062009
  • cation channel activity
    		•  3.61025292543387 bayes_pls_golite062009
  • ion channel activity
    		•  3.49583875363169 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.99565487349638 bayes_pls_golite062009
  • transporter activity
    		•  2.8998330876169 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.85192191539872 bayes_pls_golite062009
  • cAMP-dependent protein kinase regulator activity
    		•  2.78017841119787 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.66890994787635 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.66781824266082 bayes_pls_golite062009
  • channel activity
    		•  2.66781824266082 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.64973131242976 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.62037413430064 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.28218867890883 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.24699267672716 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.97137082688083 bayes_pls_golite062009
  • binding
    		•  1.80151718402565 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  1.68618484766279 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62633054482127 bayes_pls_golite062009
  • DNA binding
    		•  1.54942974151543 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.40720858109605 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14697837766975 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.944734749939467 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.930640481652164 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.921648634540942 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.910527807644534 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.848189810874263 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
  • nucleotide binding
    		•  0.274529576258456 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.26553997342843 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.26063388960068 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0296966221249605 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0295376254112757 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.025744194913981 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle