YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|61361334, gi\|...
Organism:	synthetic construct
Length:	341 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|61361334, gi|....

Description	E-value	Query Range	Subject Range
gi\|30583863, gi\|... - gi\|60653587\|gb\|AAX29487.1\| hydroxysteroid (17-beta) dehydrogenase 7 [synthetic construct], gi\|305838...	2.0E-59	[1..341]	[1..341]
gi\|33150794 - gi\|33150794\|gb\|AAP97275.1\|AF145023_1 ovarian-specific protein; OSP [Homo sapiens]	3.0E-59	[1..341]	[1..341]
gi\|114561037 - gi\|114561037\|ref\|XP_001174381.1\| PREDICTED: hydroxysteroid (17-beta) dehydrogenase 7 isoform 2 [Pan ...	3.0E-59	[1..341]	[1..341]
gi\|219540094, gi... - gi\|68206640\|ref\|ZP_00558823.1\| Glucose/ribitol dehydrogenase [Desulfitobacterium hafniense DCB-2], g...	8.0E-59	[4..292]	[7..247]
gi\|89098688, gi\|... - gi\|89098688\|ref\|ZP_01171570.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus sp. NRRL B-149...	1.0E-58	[1..292]	[1..247]
gi\|27262214 - gi\|27262214\|gb\|AAN87388.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Heliobacillus mobilis]	1.0E-58	[3..292]	[15..256]
gi\|25283158 - pir\|\|C83961 3-oxoacyl-(acyl-carrier protein) reductase fabG [imported] - Bacillus halodurans (strain... gi\|10175111, gi\|... - gi\|15615054\|ref\|NP_243357.1\| 3-oxoacyl-(acyl-carrier protein) reductase [Bacillus halodurans C-125],...	2.0E-58	[3..292]	[5..246]
gi\|255313843 - gi\|255313843\|ref\|ZP_05355426.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255516524 - gi\|255516524\|ref\|ZP_05384200.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255649624 - gi\|255649624\|ref\|ZP_05396526.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|254974717 - gi\|254974717\|ref\|ZP_05271189.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255092105 - gi\|255092105\|ref\|ZP_05321583.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile CI... gi\|90575404, gi\|... - gi\|90575404\|ref\|ZP_01231888.1\| hypothetical protein CdifQ_02001165 [Clostridium difficile QCD-32g58]...	4.0E-58	[3..292]	[7..248]

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Predicted Domain #1

Region A:
Residues: [1-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV  60
   61 QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA 120
  121 EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS 180
  181 LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW 240
  241 TLLMPAILLL RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ 300
  301 KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.045757
Match:	1yxmA
Description:	Crystal structure of peroxisomal trans 2-enoyl CoA reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
retinol dehydrogenase activity	4.16823156055592	bayes_pls_golite062009
steroid dehydrogenase activity	3.70115036051018	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	3.56748749904419	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.27417613545298	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.97774592602866	bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity	1.80383455383329	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
retinoid binding	1.72614743805853	bayes_pls_golite062009
isoprenoid binding	1.61095405873981	bayes_pls_golite062009
alcohol binding	1.07158175924364	bayes_pls_golite062009
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	1.03845584151228	bayes_pls_golite062009
molecular transducer activity	0.620476349006324	bayes_pls_golite062009
signal transducer activity	0.620476349006324	bayes_pls_golite062009
binding	0.553666136934364	bayes_pls_golite062009
oxidoreductase activity	0.39101464838432	bayes_pls_golite062009
retinol binding	0.343379136183648	bayes_pls_golite062009
11-beta-hydroxysteroid dehydrogenase activity	0.29049379068443	bayes_pls_golite062009
NADPH:quinone reductase activity	0.0822919343613215	bayes_pls_golite062009
receptor activity	0.0485610523889735	bayes_pls_golite062009
ethanol binding	0.0448614072391299	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: