YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|116805330, gi...
Organism:	Homo sapiens
Length:	731 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|116805330, gi....

Description	E-value	Query Range	Subject Range
KCNN3 - potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.0	[1..731]	[1..736]
KCNN3_PIG - Small conductance calcium-activated potassium channel protein 3 OS=Sus scrofa GN=KCNN3 PE=2 SV=1	0.0	[1..731]	[1..724]
gi\|72172134 - gi\|72172134\|gb\|AAZ66791.1\| small conductance calcium-activated potassium channel 3 [Mus musculus]	0.0	[1..731]	[1..731]
KCNN3_RAT - Small conductance calcium-activated potassium channel protein 3 OS=Rattus norvegicus GN=Kcnn3 PE=2 S...	0.0	[1..731]	[1..732]
gi\|76612086 - gi\|76612086\|ref\|XP_873779.1\| PREDICTED: similar to calcium activated potassium channel SK3 isoform 2...	0.0	[1..731]	[1..721]

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Predicted Domain #1

Region A:
Residues: [1-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ  60
   61 PQPPQLQQQQ QQQQQQQQQQ PPHPLSQLAQ LQSQPVHPGL LHSSPTAFRA PPSSNSTAIL 120
  121 HPSSRQGSQL NLNDHLLGHS PSSTATSGPG GGSRHRQASP LVHRRDSNPF TEIAMSSCKY 180
  181 SGGVMKPLSR LSASRRNLIE AETEGQPLQL FSPSNPPEIV ISSREDNHAH QTLLHHPNAT 240
  241 HNHQHAGTTA SSTTFPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.39794
Match:	1y0fA
Description:	No description for 1y0fA was found.

Predicted Domain #2

Region A:
Residues: [258-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANKRKNQNIG YKLGHRRALF EKRKRLSDYA LIFGMFGIVV MVIETELSWG LYSKDSMFS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	23.221849
Match:	PF03530.5
Description:	No description for PF03530.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [317-560]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LALKCLISLS TIILLGLIIA YHTREVQLFV IDNGADDWRI AMTYERILYI SLEMLVCAIH  60
   61 PIPGEYKFFW TARLAFSYTP SRAEADVDII LSIPMFLRLY LIARVMLLHS KLFTDASSRS 120
  121 IGALNKINFN TRFVMKTLMT ICPGTVLLVF SISLWIIAAW TVRVCERYHD QQDVTSNFLG 180
  181 AMWLISITFL SIGYGDMVPH TYCGKGVCLL TGIMGAGCTA LVVAVVARKL ELTKAEKHVH 240
  241 NFMM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.69897
Match:	1orqC
Description:	Potassium channel KVAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
voltage-gated potassium channel activity	12.0716262326447	bayes_pls_golite062009
potassium channel activity	12.0564503263181	bayes_pls_golite062009
voltage-gated cation channel activity	11.2479281243224	bayes_pls_golite062009
voltage-gated ion channel activity	11.0164314117387	bayes_pls_golite062009
voltage-gated channel activity	10.9923023836994	bayes_pls_golite062009
metal ion transmembrane transporter activity	9.85051068330727	bayes_pls_golite062009
cation channel activity	9.62064031772276	bayes_pls_golite062009
ion channel activity	8.91395130684665	bayes_pls_golite062009
gated channel activity	8.84587381436962	bayes_pls_golite062009
channel activity	8.68489845295557	bayes_pls_golite062009
passive transmembrane transporter activity	8.68489845295557	bayes_pls_golite062009
substrate-specific channel activity	8.67927944890782	bayes_pls_golite062009
ligand-gated ion channel activity	5.74511802205447	bayes_pls_golite062009
ligand-gated channel activity	5.74511802205447	bayes_pls_golite062009
cation transmembrane transporter activity	5.13805155650973	bayes_pls_golite062009
inward rectifier potassium channel activity	5.0997110076666	bayes_pls_golite062009
ion transmembrane transporter activity	5.04374327766634	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.64120459994573	bayes_pls_golite062009
transporter activity	2.93091397928047	bayes_pls_golite062009
transmembrane transporter activity	2.82224868778929	bayes_pls_golite062009
substrate-specific transporter activity	2.79688978937497	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [561-644]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTQLTKRIKN AAANVLRETW LIYKHTKLLK KIDHAKVRKH QRKFLQAIHQ LRSVKMEQRK  60
   61 LSDQANTLVD LSKMQNVMYD LITE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	20.045757
Match:	1g4yB
Description:	Small-conductance potassium channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
potassium channel activity	12.9154216859515	bayes_pls_golite062009
metal ion transmembrane transporter activity	10.690117627191	bayes_pls_golite062009
cation channel activity	10.4729582700993	bayes_pls_golite062009
ion channel activity	9.76420146980976	bayes_pls_golite062009
gated channel activity	9.69845089208228	bayes_pls_golite062009
channel activity	9.53251272468341	bayes_pls_golite062009
passive transmembrane transporter activity	9.53251272468341	bayes_pls_golite062009
substrate-specific channel activity	9.52766364291262	bayes_pls_golite062009
cation transmembrane transporter activity	5.94944590079392	bayes_pls_golite062009
ion transmembrane transporter activity	5.84582254185274	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.42471865207378	bayes_pls_golite062009
calcium-activated potassium channel activity	4.85096783740785	bayes_pls_golite062009
ion gated channel activity	3.66857233866209	bayes_pls_golite062009
transporter activity	3.65156094985283	bayes_pls_golite062009
substrate-specific transporter activity	3.56349914685586	bayes_pls_golite062009
transmembrane transporter activity	3.5594499564237	bayes_pls_golite062009
small conductance calcium-activated potassium channel activity	3.44162773824006	bayes_pls_golite062009
calcium activated cation channel activity	3.35031790098165	bayes_pls_golite062009
protein binding	1.61033690476624	bayes_pls_golite062009
binding	1.32969330984971	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [645-731]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNDRSEDLEK QIGSLESKLE HLTASFNSLP LLIADTLRQQ QQQLLSAIIE ARGVSVAVGT  60
   61 THTPISDSPI GVSSTSFPTP YTSSSSC

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: