YRC Public Data Repository - Protein Structure Prediction

Protein:	ERCC5
Organism:	Homo sapiens
Length:	1186 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERCC5.

Description	E-value	Query Range	Subject Range
gi\|109121254 - gi\|109121254\|ref\|XP_001096257.1\| PREDICTED: XPG-complementing protein [Macaca mulatta]	0.0	[31..1186]	[579..1730]
gi\|62088204 - gi\|62088204\|dbj\|BAD92549.1\| DNA-repair protein complementing XP-G cells variant [Homo sapiens]	0.0	[31..1170]	[456..1595]
gi\|114650610 - gi\|114650610\|ref\|XP_509723.2\| PREDICTED: similar to DNA-repair protein complementing XP-G cells vari...	0.0	[31..1170]	[599..1738]
gi\|60811379 - gi\|60811379\|gb\|AAX36171.1\| excision repair cross-complementing rodent repair deficiency complementat...	0.0	[1..1170]	[1..1170]
gi\|1209080, gi\|1... - gi\|6756023\|ref\|NP_035859.1\| excision repair cross-complementing rodent repair deficiency, complement...	0.0	[1..1186]	[1..1170]

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Predicted Domain #1

Region A:
Residues: [1-329]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVQGLWKLL ECSGRQVSPE ALEGKILAVD ISIWLNQALK GVRDRHGNSI ENPHLLTLFH  60
   61 RLCKLLFFRI RPIFVFDGDA PLLKKQTLVK RRQRKDLASS DSRKTTEKLL KTFLKRQAIK 120
  121 TAFRSKRDEA LPSLTQVRRE NDLYVLPPLQ EEEKHSSEEE DEKEWQERMN QKQALQEEFF 180
  181 HNPQAIDIES EDFSSLPPEV KHEILTDMKE FTKRRRTLFE AMPEESDDFS QYQLKGLLKK 240
  241 NYLNQHIEHV QKEMNQQHSG HIRRQYEDEG GFLKEVESRR VVSEDTSHYI LIKGIQAKTV 300
  301 AEVDSESLPS SSKMHGMSFD VKSSPCEKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.0
Match:	1ul1X
Description:	Crystal structure of the human FEN1-PCNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
single-stranded DNA specific endodeoxyribonuclease activity	4.11750564105954	bayes_pls_golite062009
flap endonuclease activity	4.10438637013244	bayes_pls_golite062009
endodeoxyribonuclease activity	4.07340135619133	bayes_pls_golite062009
deoxyribonuclease activity	4.00347149381256	bayes_pls_golite062009
exonuclease activity	3.99717729574528	bayes_pls_golite062009
endonuclease activity	3.40075034200919	bayes_pls_golite062009
5'-3' exonuclease activity	3.19536858640519	bayes_pls_golite062009
nuclease activity	2.9643999717473	bayes_pls_golite062009
hydrolase activity	2.80884894948531	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2.66071760609476	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	2.50398903419616	bayes_pls_golite062009
exodeoxyribonuclease activity	2.49591627688404	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.45364009363271	bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity	2.26658239783943	bayes_pls_golite062009
damaged DNA binding	2.10834170214137	bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity	2.09057967200253	bayes_pls_golite062009
binding	2.06833406478856	bayes_pls_golite062009
5'-flap endonuclease activity	1.81850767854435	bayes_pls_golite062009
structure-specific DNA binding	1.70042864382698	bayes_pls_golite062009
DNA binding	1.67328600485167	bayes_pls_golite062009
nucleic acid binding	1.61574912542722	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	1.61167902830399	bayes_pls_golite062009
catalytic activity	1.37534898662234	bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	1.15948049342759	bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.901965019685213	bayes_pls_golite062009
ribonuclease activity	0.6888465193558	bayes_pls_golite062009
nucleotidyltransferase activity	0.635612216135205	bayes_pls_golite062009
double-stranded DNA binding	0.626785110524684	bayes_pls_golite062009
3'-5' exonuclease activity	0.50487165366129	bayes_pls_golite062009
protein binding	0.488846604207788	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.184182067728799	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.176453677293411	bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	0.14861832363159	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.0941467407417242	bayes_pls_golite062009
DNA polymerase activity	0.0691107435153178	bayes_pls_golite062009
3'-5'-exodeoxyribonuclease activity	0.0205129272358	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [330-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTEKEPDATP PSPRTLLAMQ AALLGSSSEE ELESENRRQA RGRNAPAAVD EGSISPRTLS  60
   61 AIKRALDDDE DVKV

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [404-590]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CAGDDVQTGG PGAEEMRINS STENSDEGLK VRDGKGIPFT ATLASSSVNS AEEHVASTNE  60
   61 GREPTDSVPK EQMSLVHVGT EAFPISDESM IKDRKDRLPL ESAVVRHSDA PGLPNGRELT 120
  121 PASPTCTNSV SKNETHAEVL EQQNELCPYE SKFDSSLLSS DDETKCKPNS ASEVIGPVSL 180
  181 QETSSIV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [591-683]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPSEAVDNV ENVVSFNAKE HENFLETIQE QQTTESAGQD LISIPKAVEP MEIDSEESES  60
   61 DGSFIEVQSV ISDEELQAEF PETSKPPSEQ GEE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [684-1071]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELVGTREGEA PAESESLLRD NSERDDVDGE PQEAEKDAED SLHEWQDINL EELETLESNL  60
   61 LAQQNSLKAQ KQQQERIAAT VTGQMFLESQ ELLRLFGIPY IQAPMEAEAQ CAILDLTDQT 120
  121 SGTITDDSDI WLFGARHVYR NFFNKNKFVE YYQYVDFHNQ LGLDRNKLIN LAYLLGSDYT 180
  181 EGIPTVGCVT AMEILNEFPG HGLEPLLKFS EWWHEAQKNP KIRPNPHDTK VKKKLRTLQL 240
  241 TPGFPNPAVA EAYLKPVVDD SKGSFLWGKP DLDKIREFCQ RYFGWNRTKT DESLFPVLKQ 300
  301 LDAQQTQLRI DSFFRLAQQE KEDAKRIKSQ RLNRAVTCML RKEKEAAASE IEAVSVAMEK 360
  361 EFELLDKAKG KTQKRGITNT LEESSSLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.0
Match:	2izoA
Description:	No description for 2izoA was found.

Predicted Domain #6

Region A:
Residues: [1072-1186]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKRLSDSKGK NTCGGFLGET CLSESSDGSS SEDAESSSLM NVQRRTAAKE PKTSASDSQN  60
   61 SVKEAPVKNG GATTSSSSDS DDDGGKEKMV LVTARSVFGK KRRKLRRARG RKRKT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: