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View Structure Prediction Details

Protein: gi|55749567
Organism: SPECIES UNKNOWN
Length: 282 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|55749567.

Description E-value Query
Range		 Subject
Range
gi|76640366 - gi|76640366|ref|XP_875974.1| PREDICTED: similar to seven in absentia homolog 1 isoform b [Bos taurus...
 6.0E-80 [1..282] [254..535]
gi|50753723 - gi|50753723|ref|XP_414105.1| PREDICTED: similar to SIAH1 protein [Gallus gallus]
 3.0E-79 [1..282] [370..651]
gi|55749557, gi|... - gi|55749557|ref|NP_001006611.1| seven in absentia homolog 1 isoform b [Homo sapiens], gi|27503514|gb...
CCDS32444.1_1 - null
gi|109128439 - gi|109128439|ref|XP_001114300.1| PREDICTED: seven in absentia homolog 1 (Drosophila) isoform 1 [Maca...
gi|55749557 - ref|NP_001006611.1| seven in absentia homolog 1 isoform b [Homo sapiens]
ENSPTRT00000014925 - null
 7.0E-78 [1..282] [32..313]
gi|68389919 - gi|68389919|ref|XP_707669.1| PREDICTED: similar to Seven in absentia 1A isoform 2 [Danio rerio]
 9.0E-78 [1..282] [53..334]
gi|57043872 - gi|57043872|ref|XP_544419.1| PREDICTED: similar to seven in absentia homolog 1 isoform b isoform 1 [...
 1.0E-77 [1..282] [32..313]
gi|60654479 - gi|60654479|gb|AAX29930.1| seven in absentia-like 1 [synthetic construct]
 1.0E-76 [1..282] [1..282]
gi|62751353, gi|... - gi|62751353|ref|NP_001015836.1| seven in absentia homolog 1 [Xenopus (Silurana) tropicalis], gi|5847...
gi|49117837, gi|... - gi|49117837|gb|AAH72747.1| MGC79105 protein [Xenopus laevis], gi|148231169|ref|NP_001085438.1| MGC79...
 1.0E-76 [1..282] [1..282]
SIAH1_RAT - E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2
tr|G3HYR1|G3HYR1... - E3 ubiquitin-protein ligase OS=Cricetulus griseus GN=H671_3g8983 PE=3 SV=1
SIA1A_MOUSE - E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1
 2.0E-76 [1..282] [1..282]

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Predicted Domain #1
Region A:
Residues: [1-77] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL  60
   61 VCSNCRPKLT CCPTCRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 1rmdA
Description: RAG1 DIMERIZATION DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.32809533104435 bayes_pls_golite062009
small conjugating protein ligase activity 5.17943669371679 bayes_pls_golite062009
acid-amino acid ligase activity 4.2482314105959 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.15929427993458 bayes_pls_golite062009
protein binding 1.49775478023418 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.786612602432575 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
peptidase activity 0.629020501929934 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.616462655649223 bayes_pls_golite062009
ubiquitin-specific protease activity 0.549461161056205 bayes_pls_golite062009
transcription regulator activity 0.181063140818134 bayes_pls_golite062009
cysteine-type peptidase activity 0.159023519781458 bayes_pls_golite062009
hydrolase activity 0.156835837705934 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
nucleic acid binding 0.125491277540945 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [78-282] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGSIRNLAM EKVANSVLFP CKYASSGCEI TLPHTEKADH EELCEFRPYS CPCPGASCKW  60
   61 QGSLDAVMPH LMHQHKSITT LQGEDIVFLA TDINLPGAVD WVMMQSCFGF HFMLVLEKQE 120
  121 KYDGHQQFFA IVQLIGTRKQ AENFAYRLEL NGHRRRLTWE ATPRSIHEGI ATAIMNSDCL 180
  181 VFDTSIAQLF AENGNLGINV TISMC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.522879
Match: 2a25A
Description: Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle