YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: gi|38327510
Organism: Cloning vector pPGA89
Length: 571 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|38327510.

Description E-value Query
Range		 Subject
Range
gi|151945749 - gi|151945749|gb|EDN63990.1| phosphoribosylaminoimidazole carboxylase [Saccharomyces cerevisiae YJM78...
gi|195972362 - gi|195972362|gb|ACG61339.1| ADE-1 [Expression vector pYAA-ZP-MCS]
gi|3243009 - gi|3243009|gb|AAC23867.1| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-A]
gi|3243012 - gi|3243012|gb|AAC23869.1| phosphoribosylaminoimidazole carboxylase [Expression vector pBEVY-GA]
gi|3243116 - gi|3243116|gb|AAC40224.1| phosphoribosylamino-imidazole-carboxylase [Integrating expression vector Y...
gi|38327510 - gi|38327510|gb|AAR17787.1| phosphoribosylamino-imidazole-carboxylase [Cloning vector pPGA89]
PUR6_YEAST - Phosphoribosylaminoimidazole carboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
ADE2 - Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosyn...
 0.0 [1..571] [1..571]
gi|1813614 - gi|1813614|gb|AAC49742.1| phosphoribosylaminoimidazole carboxylase [Candida albicans]
 0.0 [1..571] [1..565]
PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata GN=ADE2 PE=3 SV=2
PUR6_CANGA - Phosphoribosylaminoimidazole carboxylase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 ...
 0.0 [1..571] [1..570]
PUR6_SCHOC - Phosphoribosylaminoimidazole carboxylase OS=Schwanniomyces occidentalis GN=ADE2 PE=3 SV=1
 0.0 [1..567] [1..557]
gi|6018748, gi|1... - gi|6018748|emb|CAB57994.1| phosphoribosylaminoimidazole carboxylase [Zygosaccharomyces rouxii], gi|2...
gi|254585243 - gi|254585243|ref|XP_002498189.1| ZYRO0G04400p [Zygosaccharomyces rouxii]
gi|146189516 - gi|146189516|emb|CAM91751.1| phosphoribosylaminoimidazole carboxylase [Cloning vector pZCAA]
gi|146189499 - gi|146189499|emb|CAM91225.1| phosphoribosylaminoimidazole carboxylase [Cloning vector pZEA]
 0.0 [1..568] [1..567]
gi|18482492 - gi|18482492|gb|AAL68881.1| phosphoribosylaminoimidazole carboxylase [Dipodascus magnusii]
 0.0 [1..571] [1..581]
PUR6_SCHPO - Phosphoribosylaminoimidazole carboxylase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=a...
ade6 - phosphoribosylaminoimidazole carboxylase Ade6
 0.0 [1..567] [1..550]
PUR6_PICME - Phosphoribosylaminoimidazole carboxylase OS=Pichia methanolica GN=ADE1 PE=3 SV=1
PUR6_OGAME - Phosphoribosylaminoimidazole carboxylase OS=Ogataea methanolica GN=ADE1 PE=3 SV=1
 0.0 [1..535] [1..534]

Back

Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSRTVGILG GGQLGRMIVE AANRLNIKTV ILDAENSPAK QISNSNDHVN GSFSNPLDIE  60
   61 KLAEKCDVLT IEIEHVDVPT LKNLQVKHPK LKIYPSPETI RLIQDKYIQK EHLIKNGIAV 120
  121 TQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 342.917458
Match: 1b6rA_
Description: N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoribosylaminoimidazole carboxylase activity 8.30252180826751 bayes_pls_golite062009
carboxy-lyase activity 4.46679646341684 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.99262646198755 bayes_pls_golite062009
carbamoyl-phosphate synthase activity 2.80055235272563 bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 2.72231827182887 bayes_pls_golite062009
catalytic activity 1.681309422157 bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity 1.37477732460326 bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity 1.20917335424321 bayes_pls_golite062009
ligase activity 1.13657217096051 bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1.11645327303429 bayes_pls_golite062009
methyltransferase activity 1.01641658620582 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.94663663480966 bayes_pls_golite062009
acid-amino acid ligase activity 0.730894973410499 bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity 0.56822429064158 bayes_pls_golite062009
binding 0.552939485505354 bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates 0.344740566585736 bayes_pls_golite062009
protein binding 0.259473641428437 bayes_pls_golite062009
glycine hydroxymethyltransferase activity 0.258234666901931 bayes_pls_golite062009
glutathione synthase activity 0.0685848191991462 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [123-185] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPVEQASET SLLNVGRDLG FPFVLKSRTL AYDGRGNFVV KNKEMIPEAL EVLKDRPLYA  60
   61 EKW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 342.917458
Match: 1b6rA_
Description: N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoribosylaminoimidazole carboxylase activity 12.126616405613 bayes_pls_golite062009
carboxy-lyase activity 8.23768576957333 bayes_pls_golite062009
carbon-carbon lyase activity 2.36590642968819 bayes_pls_golite062009
catalytic activity 1.94758748334979 bayes_pls_golite062009
lyase activity 0.685887227538264 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [186-393] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APFTKELAVM IVRSVNGLVF SYPIVETIHK DNICDLCYAP ARVPDSVQLK AKLLAENAIK  60
   61 SFPGCGIFGV EMFYLETGEL LINEIAPRPH NSGHYTIDAC VTSQFEAHLR SILDLPMPKN 120
  121 FTSFSTITTN AIMLNVLGDK HTKDKELETC ERALATPGSS VYLYGKESRP NRKVGHINII 180
  181 ASSMAECEQR LNYITGRTDI PIKISVAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 342.917458
Match: 1b6rA_
Description: N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), C-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), N-domain; N5-carboxyaminoimidazole ribonucleotide synthetase PurK (AIRC), domain 2
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [394-571] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLDLEAMVKP LVGIIMGSDS DLPVMSAACA VLKDFGVPFE VTIVSAHRTP HRMSAYAISA  60
   61 SKRGIKTIIA GAGGAAHLPG MVAAMTPLPV IGVPVKGSCL DGVDSLHSIV QMPRGVPVAT 120
  121 VAINNSTNAA LLAVRLLGAY DSSYTTKMEQ FLLKQEEEVL VKAQKLETVG YEAYLENK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 304.045757
Match: 1qczA_
Description: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle