YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|51980547
Organism:	Xenopus laevis
Length:	164 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|51980547.

Description	E-value	Query Range	Subject Range
gi\|50301248 - gi\|50301248\|gb\|AAT73777.1\| TRIM5/cyclophilin A fusion protein [Aotus trivirgatus]	281.0	[0..1]	[164..311]
gi\|82491991 - gi\|82491991\|gb\|ABB77877.1\| peptidylprolyl isomerase A [Gorilla gorilla] PPIA_HYLLA - Peptidyl-prolyl cis-trans isomerase A OS=Hylobates lar GN=PPIA PE=3 SV=3 PPIA_NOMLE - Peptidyl-prolyl cis-trans isomerase A OS=Nomascus leucogenys GN=PPIA PE=3 SV=3 PPIA_SYMSY - Peptidyl-prolyl cis-trans isomerase A OS=Symphalangus syndactylus GN=PPIA PE=3 SV=3 PPIA_GORGO - Peptidyl-prolyl cis-trans isomerase A OS=Gorilla gorilla gorilla GN=PPIA PE=3 SV=3 PPIA_PAPAN - Peptidyl-prolyl cis-trans isomerase A OS=Papio anubis GN=PPIA PE=2 SV=2 gi\|2565299 - gi\|2565299\|gb\|AAB81959.1\| cyclophilin A [Papio hamadryas] gi\|208967012, gi... - gi\|208967012\|dbj\|BAG73520.1\| peptidylprolyl isomerase A [synthetic construct], gi\|123998379\|gb\|ABM86... PPIA_CHLAE - Peptidyl-prolyl cis-trans isomerase A OS=Chlorocebus aethiops GN=PPIA PE=2 SV=2 gi\|90075960 - gi\|90075960\|dbj\|BAE87660.1\| unnamed protein product [Macaca fascicularis] PPIA - peptidylprolyl isomerase A (cyclophilin A) PPIA_MACMU - Peptidyl-prolyl cis-trans isomerase A OS=Macaca mulatta GN=PPIA PE=1 SV=2 gi\|31615579, gi\|... - gi\|31615580\|pdb\|1M9Y\|F Chain F, X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain ... PPIA_PANPA - Peptidyl-prolyl cis-trans isomerase A OS=Pan paniscus GN=PPIA PE=3 SV=3 PPIA_PANTR - Peptidyl-prolyl cis-trans isomerase A OS=Pan troglodytes GN=PPIA PE=3 SV=3 PPIA_PONPY - Peptidyl-prolyl cis-trans isomerase A OS=Pongo pygmaeus GN=PPIA PE=2 SV=4	267.0	[0..1]	[164..1]
gi\|55730219, gi\|... - gi\|75061782\|sp\|Q5R8S7\|PPIA_PONPY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (Rotamase A) (Cycl... gi\|197098846 - gi\|197098846\|ref\|NP_001126060.1\| peptidylprolyl isomerase A [Pongo abelii]	266.0	[0..1]	[164..1]
gi\|94381275, gi\|... - gi\|94381275\|ref\|XP_918992.2\| PREDICTED: similar to Peptidyl-prolyl cis-trans isomerase A (PPIase) (R...	266.0	[0..1]	[164..73]
gi\|114683679, gi... - gi\|114683681\|ref\|XP_001156644.1\| PREDICTED: similar to peptidylprolyl isomerase isoform 1 [Pan trogl...	265.0	[0..1]	[164..1]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNPTVFFDI TADDEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SSFHRIIPGF  60
   61 MCQGGDFTRH NGTGGRSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE 120
  121 WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITISD CGQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.0
Match:	1ak4A
Description:	Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	4.3775483906311	bayes_pls_golite062009
histone deacetylase activity	4.29026678196473	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
deacetylase activity	3.49940864924766	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.01511519120932	bayes_pls_golite062009
RNA binding	2.94609837984526	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.46018233647024	bayes_pls_golite062009
mRNA binding	1.45537055700871	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
hydrolase activity	0.493806105600863	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.408539130322443	bayes_pls_golite062009
drug binding	0.36339132904137	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.322244688184474	bayes_pls_golite062009
small conjugating protein ligase activity	0.286133802341887	bayes_pls_golite062009
histone binding	0.268719695649015	bayes_pls_golite062009
protein binding	0.130251391659493	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: