YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SENP2
Organism: Homo sapiens
Length: 589 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SENP2.

Description E-value Query
Range
Subject
Range
gi|14042385 - gi|14042385|dbj|BAB55222.1| unnamed protein product [Homo sapiens]
0.0 [1..589] [1..589]
SENP2_PONAB - Sentrin-specific protease 2 OS=Pongo abelii GN=SENP2 PE=2 SV=1
SENP2_PONPY - Sentrin-specific protease 2 - Pongo pygmaeus (Orangutan)
0.0 [1..589] [1..589]
gi|109042343 - gi|109042343|ref|XP_001095662.1| PREDICTED: SUMO1/sentrin/SMT3 specific protease 2 isoform 2 [Macaca...
0.0 [1..589] [1..588]
gi|74003536 - gi|74003536|ref|XP_535831.2| PREDICTED: similar to Sentrin-specific protease 2 (Sentrin/SUMO-specifi...
0.0 [1..589] [1..590]
gi|114590909 - gi|114590909|ref|XP_516925.2| PREDICTED: similar to KIAA1331 protein [Pan troglodytes]
0.0 [1..589] [249..821]
SENP2_MOUSE - Sentrin-specific protease 2 OS=Mus musculus GN=Senp2 PE=1 SV=2
0.0 [1..589] [1..588]
SENP2_RAT - Sentrin-specific protease 2 OS=Rattus norvegicus GN=Senp2 PE=1 SV=1
0.0 [1..589] [1..588]

Back

Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK  60
   61 NSLYNAASLF G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.395 a.1.1 Globin-like
View Download 0.469 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.390 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.325 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.319 a.1.1 Globin-like

Predicted Domain #2
Region A:
Residues: [72-263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FPFQLTTKPM VTSACNGTRN VAPSGEVFSN SSSCELTGSG SWNNMLKLGN KSPNGISDYP  60
   61 KIRVTVTRDQ PRRVLPSFGF TLNSEGCNRR PGGRRHSKGN PESSLMWKPQ EQAVTEMISE 120
  121 ESGKGLRRPH CTVEEGVQKE EREKYRKLLE RLKESGHGNS VCPVTSNYHS SQRSQMDTLK 180
  181 TKGWGEEQNH GV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [264-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTTQFVPKQY RLVETRGPLC SLRSEKRCSK GKITDTETMV GIRFENESRR GYQLEPDLSE  60
   61 EVSARLRLGS GSNGLLRRKV SIIETKEKNC SGKERDRRTD DL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.452 b.1.18 E set domains
View Download 0.505 b.1.2 Fibronectin type III
View Download 0.459 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.691 b.7.2 Periplasmic chaperone C-domain
View Download 0.458 b.1.2 Fibronectin type III

Predicted Domain #4
Region A:
Residues: [366-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LELTEDMEKE ISNALGHGPQ DEILSSAFKL RITRGDIQTL KNYHWLNDEV INFYMNLLVE  60
   61 RNKKQGYPAL HVFSTFFYPK LKSGGYQAVK RWTKGVNLFE QEIILVPIHR KVHWSLVVID 120
  121 LRKKCLKYLD SMGQKGHRIC EILLQYLQDE SKTKRNSDLN LLEWTHHSMK PHEIPQQLNG 180
  181 SDCGMFTCKY ADYISRDKPI TFTQHQMPLF RKKMVWEILH QQLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 65.69897
Match: 1tgzA
Description: Structure of human Senp2 in complex with SUMO-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SUMO-specific protease activity 7.14791995103471 bayes_pls_golite062009
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.52987342617304 bayes_pls_golite062009
ubiquitin thiolesterase activity 3.91170685383331 bayes_pls_golite062009
peptidase activity 2.99092799770282 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.70509346529146 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
endopeptidase activity 2.56654871607946 bayes_pls_golite062009
thiolester hydrolase activity 2.1617608442198 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.79166977301695 bayes_pls_golite062009
signal transducer activity 1.5684982941305 bayes_pls_golite062009
molecular transducer activity 1.5684982941305 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.874003454509364 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
transcription regulator activity 0.354062437867002 bayes_pls_golite062009
DNA binding 0.306964954191276 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.144331158319621 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle