YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30254616, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	562 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30254616, gi|....

Description	E-value	Query Range	Subject Range
gi\|72394929, gi\|... - gi\|73667767\|ref\|YP_303782.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina barkeri str. ...	0.0	[1..561]	[1..554]
gi\|20092588, gi\|... - gi\|20092588\|ref\|NP_618663.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina acetivorans C...	0.0	[1..561]	[1..554]
gi\|21226772, gi\|... - gi\|21226772\|ref\|NP_632694.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...	0.0	[1..561]	[1..553]
gi\|77919506, gi\|... - gi\|77919506\|ref\|YP_357321.1\| acetolactate synthase, large subunit, biosynthetic type [Pelobacter car...	0.0	[12..561]	[1..557]
gi\|88602528, gi\|... - gi\|88602528\|ref\|YP_502706.1\| acetolactate synthase, large subunit, biosynthetic type [Methanospirill...	0.0	[13..560]	[1..547]
gi\|146399240, gi... - gi\|88936939\|ref\|ZP_01142531.1\| Acetolactate synthase, large subunit, biosynthetic type [Geobacter ur...	0.0	[12..561]	[1..558]
gi\|219993234, gi... - gi\|89210057\|ref\|ZP_01188450.1\| Acetolactate synthase, large subunit, biosynthetic type [Halothermoth...	0.0	[11..560]	[1..547]
gi\|222054607, gi... - gi\|222054607\|ref\|YP_002536969.1\| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...	0.0	[12..561]	[1..558]
gi\|17232105, gi\|... - gi\|17232105\|ref\|NP_488653.1\| acetolactate synthase 3 catalytic subunit [Nostoc sp. PCC 7120], gi\|171... gi\|25291313 - pir\|\|AE2382 acetohydroxy acid synthase [imported] - Nostoc sp. (strain PCC 7120)	0.0	[10..562]	[29..591]
gi\|75908969, gi\|... - gi\|75908969\|ref\|YP_323265.1\| acetolactate synthase 3 catalytic subunit [Anabaena variabilis ATCC 294...	0.0	[10..562]	[29..591]

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Predicted Domain #1

Region A:
Residues: [1-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTGVKANDV KTKTKGADLV VDCLIKQGVT HVFGIPGAKI DSVFDVLQER GPELIVCRHE  60
   61 QNAAFMAAAI GRLTGKPGVC LVTSGPGTSN LATGLVTANA ESDPVVALAG AVPRTDRLKR 120
  121 THQSMDNAAL FEPITKYSVE VEHPDNVPEA LSNAFRSATS TNPGATLVSL PQDVMTAETT 180
  181 VESIGALSKP QLGIAPTHDI TYVVEKIKAA KLPVILLGMR ASTNEVTKAV RALIADTELP 240
  241 VVETYQAAGA ISRELEDHFF GRVGLFRNQP GDILLEEADL VISIGYDPIE YDPKFWNKLG 300
  301 DRTIIHLDDH QADIDHDYQP ERELIGDIAL TVNSIAERLP KLVLSTKSEA VLERLRAKLS 360
  361 EQAEVPNRDS EGVTHPLQVI RTLRSLISDD TTVTCDIGSH SIWMARCFRS YEPRRLLFSN 420
  421 GMQTLGVALP WAIAATLVEP GKKVVSVSGD GGFLFSAMEL ETAVRLNSPI VHLVWRDGTY 480
  481 DMVAFQQMMK YGRTSATEFG DVDLVKYAES FGATGLRVNT PDELEGVLKS ALAADGPVII 540
  541 DIPIDYRDNI KLSEKLLPNQ LN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	107.0
Match:	1ozfA
Description:	The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactors
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	12.903449876837	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	12.3239025230705	bayes_pls_golite062009
pyruvate dehydrogenase activity	5.28857071459273	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.21233670052586	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	5.08663245333808	bayes_pls_golite062009
transketolase activity	2.50501741089295	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.15444163802756	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.98546381612935	bayes_pls_golite062009
thiamin pyrophosphate binding	1.87247313698582	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.82969293063325	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	1.65348126142808	bayes_pls_golite062009
deoxyhypusine synthase activity	1.46517585302326	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	1.20517690263403	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.0611726850452	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.982646671777	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	0.86895852396873	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	0.86895852396873	bayes_pls_golite062009
histone deacetylase activity	0.830930720411622	bayes_pls_golite062009
protein deacetylase activity	0.824658712859653	bayes_pls_golite062009
transcription regulator activity	0.815985589880088	bayes_pls_golite062009
cation transmembrane transporter activity	0.78591260444574	bayes_pls_golite062009
binding	0.742632379338885	bayes_pls_golite062009
nucleic acid binding	0.625412573920025	bayes_pls_golite062009
DNA binding	0.57275483406399	bayes_pls_golite062009
hydrolase activity	0.536729211484905	bayes_pls_golite062009
ion transmembrane transporter activity	0.51426028502998	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
deacetylase activity	0.34210759801484	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: