YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24350835, gi\|...
Organism:	Shewanella oneidensis MR-1
Length:	500 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24350835, gi|....

Description	E-value	Query Range	Subject Range
gi\|73668585, gi\|... - gi\|73668585\|ref\|YP_304600.1\| sensory transduction histidine kinase [Methanosarcina barkeri str. Fusa...	260.0	[0..46]	[500..270]
gi\|51974390, gi\|... - gi\|52140921\|ref\|YP_085908.1\| phosphate regulon sensor protein [Bacillus cereus E33L], gi\|51974390\|gb...	259.0	[0..90]	[498..186]
gi\|47557784, gi\|... - gi\|47564998\|ref\|ZP_00236041.1\| sensory box histidine kinase PhoR [Bacillus cereus G9241], gi\|4755778...	259.0	[0..90]	[498..186]
gi\|89154470, gi\|... - gi\|89207576\|ref\|ZP_01186114.1\| PAS [Bacillus weihenstephanensis KBAB4], gi\|89154470\|gb\|EAR74501.1\| P...	258.0	[0..90]	[498..186]
gi\|42783765, gi\|... - gi\|42783765\|ref\|NP_981012.1\| sensory box histidine kinase PhoR [Bacillus cereus ATCC 10987], gi\|4273...	257.0	[0..90]	[498..186]
gi\|49330250, gi\|... - gi\|49478694\|ref\|YP_038633.1\| phosphate regulon sensor protein [Bacillus thuringiensis serovar konkuk...	257.0	[0..90]	[498..186]
gi\|30264658, gi\|... - gi\|30264658\|ref\|NP_847035.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Ames], gi\|30... gi\|65321955, gi\|... - gi\|65321955\|ref\|ZP_00394914.1\| COG0642: Signal transduction histidine kinase [Bacillus anthracis str... gi\|165869708, gi... - gi\|165869708\|ref\|ZP_02214366.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0488], g... gi\|167530779, gi... - gi\|167633978\|ref\|ZP_02392301.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0442], g... gi\|167513830, gi... - gi\|167638013\|ref\|ZP_02396291.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0193], g... gi\|47530128, gi\|... - gi\|47530128\|ref\|YP_021477.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. 'Ames Ancest... gi\|170685740, gi... - gi\|170685740\|ref\|ZP_02876963.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0465], g... gi\|254757502 - gi\|254757502\|ref\|ZP_05209529.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Australia... gi\|254754670 - gi\|254754670\|ref\|ZP_05206705.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Vollum] gi\|254741732 - gi\|254741732\|ref\|ZP_05199419.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Kruger B] gi\|254736695 - gi\|254736695\|ref\|ZP_05194401.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Western N... gi\|254724958 - gi\|254724958\|ref\|ZP_05186741.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A1055] gi\|254687395 - gi\|254687395\|ref\|ZP_05151251.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. CNEVA-906... gi\|229264805, gi... - gi\|229600397\|ref\|YP_002868867.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0248], ... gi\|170705359, gi... - gi\|170705359\|ref\|ZP_02895823.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0389], g... gi\|227004296, gi... - gi\|227817372\|ref\|YP_002817381.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. CDC 684]... gi\|177651147, gi... - gi\|177651147\|ref\|ZP_02933978.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. A0174], g... gi\|190559871, gi... - gi\|190569089\|ref\|ZP_03021989.1\| sensory box histidine kinase PhoR [Bacillus anthracis Tsiankovskii-I... gi\|196032783, gi... - gi\|196032783\|ref\|ZP_03100196.1\| sensory box histidine kinase PhoR [Bacillus cereus W], gi\|195994212\|... gi\|218905815, gi... - gi\|218905815\|ref\|YP_002453649.1\| sensory box histidine kinase PhoR [Bacillus cereus AH820], gi\|21854...	257.0	[0..90]	[498..186]
gi\|74490501, gi\|... - gi\|75762015\|ref\|ZP_00741929.1\| Phosphate regulon sensor protein phoR [Bacillus thuringiensis serovar... gi\|218899741, gi... - gi\|218899741\|ref\|YP_002448152.1\| sensory box histidine kinase PhoR [Bacillus cereus G9842], gi\|21854...	257.0	[0..90]	[498..186]
gi\|30022663, gi\|... - gi\|30022663\|ref\|NP_834294.1\| phosphate regulon sensor protein phoR [Bacillus cereus ATCC 14579], gi\|...	257.0	[0..90]	[498..186]
gi\|49187478, gi\|... - gi\|49187478\|ref\|YP_030730.1\| sensory box histidine kinase PhoR [Bacillus anthracis str. Sterne], gi\|...	256.0	[0..90]	[498..186]

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Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTQNYEHYLF LFVIITGLIM GVISYFGFRA LTQESTLNEY QTQQLAKSHV AQTQSFILQQ  60
   61 LNQKQVRLDA MLAYLSLDKN ALHTLISQDS DIENIFVLQK NKLAFPDISQ PLSLKDQTLA 120
  121 ELIMPISHDP TLLMAKQPTS ED

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [143-266]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSPNSGWLVL QDNNYPALIY WRKTDEDTVG IKLSYVKFLA DVISALDTNF TPDGIKISDN  60
   61 GQVLYQLSPE PIGNNQTPSY SQNLPFPLHG WQIDYYTAPV KGQSLYYLGT ILIVTIILAV 120
  121 GFMA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.045757
Match:	1d06A
Description:	Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ion transmembrane transporter activity	1.94020112661684	bayes_pls_golite062009
binding	1.79230776794479	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.70629448457771	bayes_pls_golite062009
cation transmembrane transporter activity	1.55042643398568	bayes_pls_golite062009
two-component response regulator activity	1.45691562840107	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.31850321187865	bayes_pls_golite062009
transcription regulator activity	1.13913685347546	bayes_pls_golite062009
protein binding	1.0133195984081	bayes_pls_golite062009
potassium channel activity	0.93265112299626	bayes_pls_golite062009
voltage-gated ion channel activity	0.92661046549451	bayes_pls_golite062009
voltage-gated cation channel activity	0.926512767264521	bayes_pls_golite062009
voltage-gated potassium channel activity	0.92204538811959	bayes_pls_golite062009
voltage-gated channel activity	0.91469735366704	bayes_pls_golite062009
ion channel activity	0.75430461252947	bayes_pls_golite062009
cation channel activity	0.73262554730695	bayes_pls_golite062009
DNA binding	0.73243452463464	bayes_pls_golite062009
gated channel activity	0.67217953143815	bayes_pls_golite062009
substrate-specific channel activity	0.650205954115699	bayes_pls_golite062009
channel activity	0.64202076714636	bayes_pls_golite062009
passive transmembrane transporter activity	0.64202076714636	bayes_pls_golite062009
two-component sensor activity	0.58151911764083	bayes_pls_golite062009
protein histidine kinase activity	0.56538125817883	bayes_pls_golite062009
nucleic acid binding	0.5545839402512	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.518111391350209	bayes_pls_golite062009
signal transducer activity	0.441034662376355	bayes_pls_golite062009
molecular transducer activity	0.441034662376355	bayes_pls_golite062009
transcription factor activity	0.36759096137141	bayes_pls_golite062009
transporter activity	0.360938622392148	bayes_pls_golite062009
catalytic activity	0.285447488878019	bayes_pls_golite062009
transmembrane transporter activity	0.217804199010847	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [267-500]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FMLYREFNRA TRLASQQVSF VGQVSHELKT PLTNITLYAE MLNEMEAEEN DQRAHYLGVI  60
   61 ISESQRLSRL IQNVLTFTKL PQICIRQVDI NQLMNQIYTA FKPVFEAKEI HLNLNINGQL 120
  121 STKTDVDLVT QIISNLLSNA EKYAATGKQV DLNVEQDNDN IFIHIRDYGN GITAKELKQI 180
  181 FQPFYRVRSS ITEGVSGTGI GLTIARQLAE TLSGEINAIN NEPGMTFTLR LPKR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.69897
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: