| Protein: | XRN1_YEAST |
| Organism: | Saccharomyces cerevisiae S288c |
| Length: | 1528 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for XRN1_YEAST.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..1247] | [1..1213] |
|
|
0.0 | [1..1247] | [1..1212] |
|
|
0.0 | [1..1236] | [1..1174] |
|
|
0.0 | [1..1528] | [1..1528] |
|
|
0.0 | [1..685] | [1..691] |
|
Region A: Residues: [1-231] |
1 11 21 31 41 51
| | | | | |
1 MGIPKFFRYI SERWPMILQL IEGTQIPEFD NLYLDMNSIL HNCTHGNDDD VTKRLTEEEV 60
61 FAKICTYIDH LFQTIKPKKI FYMAIDGVAP RAKMNQQRAR RFRTAMDAEK ALKKAIENGD 120
121 EIPKGEPFDS NSITPGTEFM AKLTKNLQYF IHDKISNDSK WREVQIIFSG HEVPGEGEHK 180
181 IMNFIRHLKS QKDFNQNTRH CIYGLDADLI MLGLSTHGPH FALLREEVTF G
|
| Detection Method: |  |
| Confidence: | 171.387216 |
| Match: | PF03159 |
| Description: | XRN 5'-3' exonuclease N-terminus |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
| Term | Confidence | Notes |
| endonuclease activity | 2.8669665385948 | bayes_pls_golite062009 |
| hydrolase activity | 2.47801245425307 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.24517620525137 | bayes_pls_golite062009 |
| nuclease activity | 2.0989149357263 | bayes_pls_golite062009 |
| exonuclease activity | 1.76587867909916 | bayes_pls_golite062009 |
| endodeoxyribonuclease activity | 1.74349203224875 | bayes_pls_golite062009 |
| DNA binding | 1.695958856922 | bayes_pls_golite062009 |
| nucleic acid binding | 1.68917463278047 | bayes_pls_golite062009 |
| deoxyribonuclease activity | 1.68760157046614 | bayes_pls_golite062009 |
| ribonuclease activity | 1.49206381939599 | bayes_pls_golite062009 |
| binding | 1.42234233865461 | bayes_pls_golite062009 |
| catalytic activity | 1.27951740231695 | bayes_pls_golite062009 |
| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.79417076649627 | bayes_pls_golite062009 |
| protein binding | 0.488078371576565 | bayes_pls_golite062009 |
| flap endonuclease activity | 0.405877291452351 | bayes_pls_golite062009 |
| 5'-3' exonuclease activity | 0.371408632109349 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity, producing 5'-phosphomonoesters | 0.267787854683683 | bayes_pls_golite062009 |
| exodeoxyribonuclease activity | 0.260397221344929 | bayes_pls_golite062009 |
| ribonuclease H activity | 0.234391225960316 | bayes_pls_golite062009 |
| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters | 0.158336939964254 | bayes_pls_golite062009 |
| endoribonuclease activity | 0.097472492148219 | bayes_pls_golite062009 |
|
Region A: Residues: [232-303] |
1 11 21 31 41 51
| | | | | |
1 RRNSEKKSLE HQNFYLLHLS LLREYMELEF KEIADEMQFE YNFERILDDF ILVMFVIGND 60
61 FLPNLPDLHL NK
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.349 | a.64.1 | Saposin |
| View | Download | 0.325 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.617 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.430 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.331 | a.112.1 | Description not found. |
| View | Download | 0.307 | a.4.1 | Homeodomain-like |
| View | Download | 0.299 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.289 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.283 | a.74.1 | Cyclin-like |
| View | Download | 0.251 | a.21.1 | HMG-box |
| View | Download | 0.241 | d.58.11 | EF-G/eEF-2 domains III and V |
| View | Download | 0.239 | a.74.1 | Cyclin-like |
| View | Download | 0.216 | a.28.1 | ACP-like |
| View | Download | 0.213 | f.34.1 | Mechanosensitive channel protein MscS (YggB), transmembrane region |
| View | Download | 0.213 | a.142.1 | PTS-regulatory domain, PRD |
| View | Download | 0.213 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.212 | a.58.1 | Chemotaxis receptor methyltransferase CheR, N-terminal domain |
| View | Download | 0.207 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.205 | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
|
Region A: Residues: [304-714] |
1 11 21 31 41 51
| | | | | |
1 GAFPVLLQTF KEALLHTDGY INEHGKINLK RLGVWLNYLS QFELLNFEKD DIDVEWFNKQ 60
61 LENISLEGER KRQRVGKKLL VKQQKKLIGS IKPWLMEQLQ EKLSPDLPDE EIPTLELPKD 120
121 LDMKDHLEFL KEFAFDLGLF ITHSKSKGSY SLKMDLDSIN PDETEEEFQN RVNSIRKTIK 180
181 KYQNAIIVED KEELETEKTI YNERFERWKH EYYHDKLKFT TDSEEKVRDL AKDYVEGLQW 240
241 VLYYYYRGCP SWSWYYPHHY APRISDLAKG LDQDIEFDLS KPFTPFQQLM AVLPERSKNL 300
301 IPPAFRPLMY DEQSPIHDFY PAEVQLDKNG KTADWEAVVL ISFVDEKRLI EAMQPYLRKL 360
361 SPEEKTRNQF GKDLIYSFNP QVDNLYKSPL GGIFSDIEHN HCVEKEYITI P
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [715-1528] |
1 11 21 31 41 51
| | | | | |
1 LDSSEIRYGL LPNAKLGAEM LAGFPTLLSL PFTSSLEYNE TMVFQQPSKQ QSMVLQITDI 60
61 YKTNNVTLED FSKRHLNKVI YTRWPYLRES KLVSLTDGKT IYEYQESNDK KKFGFITKPA 120
121 ETQDKKLFNS LKNSMLRMYA KQKAVKIGPM EAIATVFPVT GLVRDSDGGY IKTFSPTPDY 180
181 YPLQLVVESV VNEDERYKER GPIPIEEEFP LNSKVIFLGD YAYGGETTID GYSSDRRLKI 240
241 TVEKKFLDSE PTIGKERLQM DHQAVKYYPS YIVSKNMHLH PLFLSKITSK FMITDATGKH 300
301 INVGIPVKFE ARHQKVLGYA RRNPRGWEYS NLTLNLLKEY RQTFPDFFFR LSKVGNDIPV 360
361 LEDLFPDTST KDAMNLLDGI KQWLKYVSSK FIAVSLESDS LTKTSIAAVE DHIMKYAANI 420
421 EGHERKQLAK VPREAVLNPR SSFALLRSQK FDLGDRVVYI QDSGKVPIFS KGTVVGYTTL 480
481 SSSLSIQVLF DHEIVAGNNF GGRLRTNRGL GLDASFLLNI TNRQFIYHSK ASKKALEKKK 540
541 QSNNRNNNTK TAHKTPSKQQ SEEKLRKERA HDLLNFIKKD TNEKNSESVD NKSMGSQKDS 600
601 KPAKKVLLKR PAQKSSENVQ VDLANFEKAP LDNPTVAGSI FNAVANQYSD GIGSNLNIPT 660
661 PPHPMNVVGG PIPGANDVAD VGLPYNIPPG FMTHPNGLHP LHPHQMPYPN MNGMSIPPPA 720
721 PHGFGQPISF PPPPPMTNVS DQGSRIVVNE KESQDLKKFI NGKQHSNGST IGGETKNSRK 780
781 GEIKPSSGTN STECQSPKSQ SNAADRDNKK DEST
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [865-938] |
1 11 21 31 41 51
| | | | | |
1 EAIATVFPVT GLVRDSDGGY IKTFSPTPDY YPLQLVVESV VNEDERYKER GPIPIEEEFP 60
61 LNSKVIFLGD YAYG
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [939-1146] |
1 11 21 31 41 51
| | | | | |
1 GETTIDGYSS DRRLKITVEK KFLDSEPTIG KERLQMDHQA VKYYPSYIVS KNMHLHPLFL 60
61 SKITSKFMIT DATGKHINVG IPVKFEARHQ KVLGYARRNP RGWEYSNLTL NLLKEYRQTF 120
121 PDFFFRLSKV GNDIPVLEDL FPDTSTKDAM NLLDGIKQWL KYVSSKFIAV SLESDSLTKT 180
181 SIAAVEDHIM KYAANIEGHE RKQLAKVP
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1147-1221] |
1 11 21 31 41 51
| | | | | |
1 REAVLNPRSS FALLRSQKFD LGDRVVYIQD SGKVPIFSKG TVVGYTTLSS SLSIQVLFDH 60
61 EIVAGNNFGG RLRTN
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
|
Region A: Residues: [1222-1528] |
1 11 21 31 41 51
| | | | | |
1 RGLGLDASFL LNITNRQFIY HSKASKKALE KKKQSNNRNN NTKTAHKTPS KQQSEEKLRK 60
61 ERAHDLLNFI KKDTNEKNSE SVDNKSMGSQ KDSKPAKKVL LKRPAQKSSE NVQVDLANFE 120
121 KAPLDNPTVA GSIFNAVANQ YSDGIGSNLN IPTPPHPMNV VGGPIPGAND VADVGLPYNI 180
181 PPGFMTHPNG LHPLHPHQMP YPNMNGMSIP PPAPHGFGQP ISFPPPPPMT NVSDQGSRIV 240
241 VNEKESQDLK KFINGKQHSN GSTIGGETKN SRKGEIKPSS GTNSTECQSP KSQSNAADRD 300
301 NKKDEST
|
| Detection Method: | |
| Confidence: | 1.23 |
| Match: | 1h1kI |
| Description: | THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA |
Matching Structure (courtesy of the PDB): |
|
