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View Structure Prediction Details

Protein: TAF6_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 516 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF6_YEAST.

Description E-value Query
Range		 Subject
Range
TAF6 - Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase...
TAF6_YEAST - Transcription initiation factor TFIID subunit 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2...
 0.0 [1..516] [1..516]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 0.0 [15..473] [10..427]
gi|220943388 - gi|220943388|gb|ACL84237.1| Taf6-PA [synthetic construct]
Taf6-PA - The gene TBP-associated factor 6 is referred to in FlyBase by the symbol Dmel\Taf6 (CG32211, FBgn001...
 0.0 [15..473] [24..441]
TAF6_MOUSE - Transcription initiation factor TFIID subunit 6 OS=Mus musculus GN=Taf6 PE=1 SV=1
 0.0 [1..470] [1..443]
gi|1109650 - gi|1109650|dbj|BAA08435.1| TFIID subunit p80 [Rattus sp.]
TAF6_RAT - Transcription initiation factor TFIID subunit 6 OS=Rattus norvegicus GN=Taf6 PE=1 SV=1
 0.0 [1..470] [1..443]
TAF6 - TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
gi|123996257, gi... - gi|123996257|gb|ABM85730.1| TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor...
 0.0 [1..470] [1..443]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [1..470] [1..443]
TAF6_XENLA - Transcription initiation factor TFIID subunit 6 OS=Xenopus laevis GN=taf6 PE=2 SV=2
 0.0 [1..470] [1..436]

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Predicted Domain #1
Region A:
Residues: [1-84] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQQQSYTI WSPQDTVKDV AESLGLENIN DDVLKALAMD VEYRILEIIE QAVKFKRHSK  60
   61 RDVLTTDDVS KALRVLNVEP LYGY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.221849
Match: 1tafB_
Description: TAF(II)62
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 9.25279783093877 bayes_pls_golite062009
lysine N-acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
histone acetyltransferase activity 5.97252613675094 bayes_pls_golite062009
N-acetyltransferase activity 4.49886535711761 bayes_pls_golite062009
DNA binding 4.49118409263799 bayes_pls_golite062009
nucleic acid binding 4.35201412176948 bayes_pls_golite062009
N-acyltransferase activity 4.22222466548509 bayes_pls_golite062009
transcription regulator activity 4.08606081850613 bayes_pls_golite062009
transcription initiation factor activity 3.96621818094279 bayes_pls_golite062009
acetyltransferase activity 3.91614625961398 bayes_pls_golite062009
acyltransferase activity 3.38611688546892 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.35015681315177 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.28941584139552 bayes_pls_golite062009
binding 3.27510691458843 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.1782337747057 bayes_pls_golite062009
transcription factor activity 2.51581622888695 bayes_pls_golite062009
transcription activator activity 1.25487495162413 bayes_pls_golite062009
transcription factor binding 1.15204005455906 bayes_pls_golite062009
transcription coactivator activity 1.1297723528047 bayes_pls_golite062009
nucleotidyltransferase activity 1.10331930589736 bayes_pls_golite062009
protein binding 1.07873333188144 bayes_pls_golite062009
centromeric DNA binding 1.03586371237592 bayes_pls_golite062009
transcription cofactor activity 1.01502031330902 bayes_pls_golite062009
transcription repressor activity 0.72554769377984 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.437760073242714 bayes_pls_golite062009
histone binding 0.218942897869955 bayes_pls_golite062009
transferase activity 0.106182831892296 bayes_pls_golite062009
sequence-specific DNA binding 0.0852726470007639 bayes_pls_golite062009
transcription corepressor activity 0.0736756545988504 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [85-194] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDGSEVNKAV SFSKVNTSGG QSVYYLDEEE VDFDRLINEP LPQVPRLPTF TTHWLAVEGV  60
   61 QPAIIQNPNL NDIRVSQPPF IRGAIVTALN DNSLQTPVTS TTASASVTDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.435 a.4.12 TrpR-like
View Download 0.331 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.360 c.53.1 Resolvase-like
View Download 0.313 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.435 a.4.12 TrpR-like
View Download 0.360 c.53.1 Resolvase-like
View Download 0.331 a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.313 a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.312 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.312 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.280 d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.260 a.7.7 BAG domain
View Download 0.232 d.137.1 Monooxygenase (hydroxylase) regulatory protein
View Download 0.200 d.52.4 YhbC-like, N-terminal domain

Predicted Domain #3
Region A:
Residues: [195-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASQHLSNVK PGQNTEVKPL VKHVLSKELQ IYFNKVISTL TAKSQADEAA QHMKQAALTS  60
   61 LRTDSGLHQL VPYFIQFIAE QITQNLSDLQ LLTTILEMIY SLLSNTSIFL DP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [475-516] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGEKVTDEDK EKLLERCGVT IGFHILKRDD AKELISAIFF GE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.22
Match: 1wq1G
Description: p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [307-474] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIHSLMPSIL TLLLAKKLGG SPKDDSPQEI HEFLERTNAL RDFAASLLDY VLKKFPQAYK  60
   61 SLKPRVTRTL LKTFLDINRV FGTYYGCLKG VSVLEGESIR FFLGNLNNWA RLVFNESGIT 120
  121 LDNIEEHLND DSNPTRTKFT KEETQILVDT VISALLVLKK DLPDLYEG

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.22
Match: 1wq1G
Description: p120GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [424-516] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GITLDNIEEH LNDDSNPTRT KFTKEETQIL VDTVISALLV LKKDLPDLYE GKGEKVTDED  60
   61 KEKLLERCGV TIGFHILKRD DAKELISAIF FGE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.841 a.112.1 Description not found.
View Download 0.734 a.112.1 Description not found.
View Download 0.667 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.622 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.575 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like

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