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View Structure Prediction Details

Protein: NGL1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 363 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NGL1_YEAST.

Description E-value Query
Range		 Subject
Range
NGL1 - Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA dead...
NGL1_YEAST - RNA exonuclease NGL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NGL1 PE=1 SV=1
gi|151945591 - gi|151945591|gb|EDN63832.1| conserved protein [Saccharomyces cerevisiae YJM789]
 0.0 [1..363] [1..363]
gi|17391192, gi|... - gi|21450299|ref|NP_659159.1| CCR4-NOT transcription complex, subunit 6-like isoform 1 [Mus musculus]...
gi|149046868, gi... - gi|157823321|ref|NP_001101825.1| CCR4-NOT transcription complex, subunit 6-like [Rattus norvegicus],...
 2.0E-96 [4..359] [167..530]
gi|6330365 - gi|6330365|dbj|BAA86508.1| KIAA1194 protein [Homo sapiens]
 1.0E-89 [4..363] [190..559]
ccr4 - CCR4-Not complex subunit Ccr4
CCR4_SCHPO - Glucose-repressible alcohol dehydrogenase transcriptional effector OS=Schizosaccharomyces pombe (str...
 8.0E-89 [26..361] [335..672]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-87 [4..362] [230..580]
CCR4_NEUCR - Glucose-repressible alcohol dehydrogenase transcriptional effector - Neurospora crassa
gi|85091025 - gi|85091025|ref|XP_958700.1| related to CCR4 protein [MIPS] [Neurospora crassa OR74A]
 7.0E-87 [26..362] [394..727]
CCR4A_ARATH - Carbon catabolite repressor protein 4 homolog 1 OS=Arabidopsis thaliana GN=CCR4-1 PE=2 SV=1
 3.0E-78 [4..363] [222..593]

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Predicted Domain #1
Region A:
Residues: [1-363] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTRRFIPVV QSTKQNIGKY VRKDARFTLL TYNMLSPSYM WPQVYTYVAE PYKNWSYRHR  60
   61 LLEKELLNTF KADIMCLQEM TARDYEDYWH DSIGVDVNYG SKFISKTPPK YWKKPVKDMD 120
  121 GVSIFYNLAK FDFISSSGIY LNQLLNVFNQ RELKYLYNKK VTLTDGASNV IGEDSLLDVL 180
  181 KGKNQVCLFV SLRHKETGTI FVVLNTHLYW KYDEVKLTQC MIIMRELSKI IKQLLPGDVK 240
  241 GQERVKILFT GDLNSTRDSL VVNFLQGQIV SHGDLNLINP MRPYLDRCVY DDIPKDYFVH 300
  301 TCYSGKLKGI FDYVWYHDSD FLLTKILTGN EVSDELLASN QLGLPNENHP SDHIPLLTEF 360
  361 KIL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.06
Match: 1hd7A
Description: DNA repair endonuclease Hap1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.03637986118891 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 2.64138912616286 bayes_pls_golite062009
transcription regulator activity 2.38142407142222 bayes_pls_golite062009
nucleic acid binding 2.36300991054709 bayes_pls_golite062009
DNA binding 2.34848945028683 bayes_pls_golite062009
binding 1.77207262408714 bayes_pls_golite062009
catalytic activity 1.63030570728465 bayes_pls_golite062009
nuclease activity 1.43406183661088 bayes_pls_golite062009
transcription coactivator activity 1.3192080792879 bayes_pls_golite062009
deoxyribonuclease activity 1.2263976316786 bayes_pls_golite062009
exonuclease activity 1.0469071871605 bayes_pls_golite062009
oxidoreductase activity 1.01237142327007 bayes_pls_golite062009
ribonuclease activity 0.921398762372674 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.816802516530232 bayes_pls_golite062009
transcription activator activity 0.794530147502372 bayes_pls_golite062009
transcription factor binding 0.676190329566283 bayes_pls_golite062009
protein binding 0.477100720412367 bayes_pls_golite062009
transcription cofactor activity 0.456888438009074 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.268550639537333 bayes_pls_golite062009
exodeoxyribonuclease activity 0.260804033000249 bayes_pls_golite062009
endonuclease activity 0.122198690326292 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle