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Protein: EFTU_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 437 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EFTU_YEAST.

Description E-value Query
Range		 Subject
Range
TUF1 - Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchang...
EFTU_YEAST - Elongation factor Tu, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TUF1...
 0.0 [1..437] [1..437]
EFTU_THICU - Elongation factor Tu OS=Thiobacillus cuprina GN=tuf PE=3 SV=1
EFTU_THIDL - Elongation factor Tu OS=Thiomonas delicata GN=tuf PE=3 SV=1
 0.0 [38..437] [2..396]
EFTU_RALSO - Elongation factor Tu OS=Ralstonia solanacearum GN=tufA PE=3 SV=1
EFTU_RALSO - Elongation factor Tu OS=Ralstonia solanacearum (strain GMI1000) GN=tufA PE=3 SV=1
 0.0 [38..437] [2..396]
gi|2624675, gi|2... - gi|2624676|pdb|1AIP|F Chain F, Ef-Tu Ef-Ts Complex From Thermus Thermophilus, gi|2624675|pdb|1AIP|E ...
 0.0 [38..437] [1..405]
EFTU_BURCE - Elongation factor Tu OS=Burkholderia cepacia GN=tuf PE=3 SV=1
 0.0 [38..437] [2..396]
gi|640371, gi|15... - gi|640371|pdb|1EFT| Chain , Elongation Factor Tu (Ef-Tu) Complexed With Guanosine-5'-(Beta,Gamma-I...
 0.0 [38..437] [1..405]

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Predicted Domain #1
Region A:
Residues: [1-44] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALLPRLLT RTAFKASGKL LRLSSVISRT FSQTTTSYAA AFDR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [243-437] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDLNKPFLMP VEDIFSISGR GTVVTGRVER GNLKKGEELE IVGHNSTPLK TTVTGIEMFR  60
   61 KELDSAMAGD NAGVLLRGIR RDQLKRGMVL AKPGTVKAHT KILASLYILS KEEGGRHSGF 120
  121 GENYRPQMFI RTADVTVVMR FPKEVEDHSM QVMPGDNVEM ECDLIHPTPL EVGQRFNIRE 180
  181 GGRTVGTGLI TRIIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1652.0
Match: 1b23P_
Description: Elongation factor Tu (EF-Tu), domain 2; Elongation factor Tu (EF-Tu); Elongation factor Tu (EF-Tu), N-terminal (G) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation elongation factor activity 8.90683166637832 bayes_pls_golite062009
structural constituent of ribosome 7.90308112669861 bayes_pls_golite062009
structural molecule activity 7.31087460425911 bayes_pls_golite062009
translation factor activity, nucleic acid binding 6.75036567581468 bayes_pls_golite062009
translation regulator activity 6.7106575654195 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
translation initiation factor activity 2.68619850021832 bayes_pls_golite062009
active transmembrane transporter activity 2.50494515048649 bayes_pls_golite062009
primary active transmembrane transporter activity 2.39629638016861 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 2.39600931083427 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
nucleic acid binding 2.39500449599674 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.36051733655256 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 2.35906629925754 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 2.35679406876731 bayes_pls_golite062009
ATPase activity, coupled 2.24901251684901 bayes_pls_golite062009
binding 2.01866595777668 bayes_pls_golite062009
substrate-specific transporter activity 1.65609907941094 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
motor activity 1.34881124154297 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.3182108176243 bayes_pls_golite062009
translation release factor activity 1.27090696996316 bayes_pls_golite062009
translation termination factor activity 1.2623252798648 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
RNA binding 0.798696391797967 bayes_pls_golite062009
transcription regulator activity 0.748437190903548 bayes_pls_golite062009
peptidyltransferase activity 0.705667095586631 bayes_pls_golite062009
ion transmembrane transporter activity 0.704934361725919 bayes_pls_golite062009
microtubule motor activity 0.60036517876321 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
GTPase activity 0.437665353870877 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 0.353150780751661 bayes_pls_golite062009
cation transmembrane transporter activity 0.282397764628576 bayes_pls_golite062009
protein binding 0.242047208982959 bayes_pls_golite062009
RNA helicase activity 0.2302541318658 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 0.12168417344278 bayes_pls_golite062009
microfilament motor activity 0.10236059675512 bayes_pls_golite062009
protein transporter activity 0.0397092337273124 bayes_pls_golite062009
protein transmembrane transporter activity 0.0378638259240902 bayes_pls_golite062009
peptide transporter activity 0.0135927378126404 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009
signal sequence binding 6.53725193420218E-4 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [45-242] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKPHVNIGTI GHVDHGKTTL TAAITKTLAA KGGANFLDYA AIDKAPEERA RGITISTAHV  60
   61 EYETAKRHYS HVDCPGHADY IKNMITGAAQ MDGAIIVVAA TDGQMPQTRE HLLLARQVGV 120
  121 QHIVVFVNKV DTIDDPEMLE LVEMEMRELL NEYGFDGDNA PIIMGSALCA LEGRQPEIGE 180
  181 QAIMKLLDAV DEYIPTPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1652.0
Match: 1b23P_
Description: Elongation factor Tu (EF-Tu), domain 2; Elongation factor Tu (EF-Tu); Elongation factor Tu (EF-Tu), N-terminal (G) domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle