YRC Public Data Repository - Protein Structure Prediction

Protein:	CYP8_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	308 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CYP8_YEAST.

Description	E-value	Query Range	Subject Range
CYP8_YEAST - Peptidyl-prolyl cis-trans isomerase CYP8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... CPR8 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide ...	2.0E-83	[1..308]	[1..308]
gi\|82491991 - gi\|82491991\|gb\|ABB77877.1\| peptidylprolyl isomerase A [Gorilla gorilla] PPIA_HYLLA - Peptidyl-prolyl cis-trans isomerase A OS=Hylobates lar GN=PPIA PE=3 SV=3 PPIA_NOMLE - Peptidyl-prolyl cis-trans isomerase A OS=Nomascus leucogenys GN=PPIA PE=3 SV=3 PPIA_SYMSY - Peptidyl-prolyl cis-trans isomerase A OS=Symphalangus syndactylus GN=PPIA PE=3 SV=3 PPIA_GORGO - Peptidyl-prolyl cis-trans isomerase A OS=Gorilla gorilla gorilla GN=PPIA PE=3 SV=3 PPIA_PAPAN - Peptidyl-prolyl cis-trans isomerase A OS=Papio anubis GN=PPIA PE=2 SV=2 gi\|2565299 - gi\|2565299\|gb\|AAB81959.1\| cyclophilin A [Papio hamadryas] gi\|208967012, gi... - gi\|208967012\|dbj\|BAG73520.1\| peptidylprolyl isomerase A [synthetic construct], gi\|123998379\|gb\|ABM86... PPIA_CHLAE - Peptidyl-prolyl cis-trans isomerase A OS=Chlorocebus aethiops GN=PPIA PE=2 SV=2 gi\|90075960 - gi\|90075960\|dbj\|BAE87660.1\| unnamed protein product [Macaca fascicularis] PPIA - peptidylprolyl isomerase A (cyclophilin A) PPIA_MACMU - Peptidyl-prolyl cis-trans isomerase A OS=Macaca mulatta GN=PPIA PE=1 SV=2 gi\|31615579, gi\|... - gi\|31615580\|pdb\|1M9Y\|F Chain F, X-Ray Crystal Structure Of Cyclophilin AHIV-1 Ca N- Terminal Domain ... PPIA_PANPA - Peptidyl-prolyl cis-trans isomerase A OS=Pan paniscus GN=PPIA PE=3 SV=3 PPIA_PANTR - Peptidyl-prolyl cis-trans isomerase A OS=Pan troglodytes GN=PPIA PE=3 SV=3 PPIA_PONPY - Peptidyl-prolyl cis-trans isomerase A OS=Pongo pygmaeus GN=PPIA PE=2 SV=4	3.0E-70	[49..217]	[1..165]
gi\|2981756, gi\|2... - gi\|2981756\|pdb\|1AWT\|L Chain L, Secypa Complexed With Hagpia, gi\|2981755\|pdb\|1AWT\|K Chain K, Secypa C... gi\|2981751\|pdb\|1... - Chain J, Cypa Complexed With Hagpia, Chain L, Cypa Complexed With Hagpia, Chain I, Cypa Complexed Wi...	2.0E-69	[50..217]	[1..164]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	8.0E-69	[50..216]	[1..163]
PPIA_RABIT - Peptidyl-prolyl cis-trans isomerase A OS=Oryctolagus cuniculus GN=PPIA PE=2 SV=3	1.0E-68	[49..216]	[1..164]
gi\|118098, gi\|49496 - gi\|49496\|emb\|CAA34961.1\| unnamed protein product [Cricetulus longicaudatus], sp\|P14851\|PPIA_CRILO Pe... PPIA_CRIGR - Peptidyl-prolyl cis-trans isomerase A OS=Cricetulus griseus GN=PPIA PE=2 SV=2	3.0E-68	[49..216]	[1..164]

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Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV NIGIVFTDPE  60
   61 SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH SYSPERDFDK ILPNGAIEGS 120
  121 SVSSSSIEET EMLAPKLPEE NHSLIHDRPG RVSMIKDDKG LKFIIETSET PLEGESVVFG 180
  181 QVTAGLKDLM DKLANVKTDE NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG 240
  241 DLEKGITLKN YLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	161.522879
Match:	1cynA_
Description:	Cyclophilin (eukaryotic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	2.94609837984526	bayes_pls_golite062009
mRNA binding	1.45537055700871	bayes_pls_golite062009
transcription regulator activity	1.26149030245805	bayes_pls_golite062009
binding	1.0658238478447	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	1.05326644345172	bayes_pls_golite062009
cis-trans isomerase activity	0.985752998974367	bayes_pls_golite062009
DNA binding	0.9531600253493	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
procollagen-proline 4-dioxygenase activity	0.482467028485988	bayes_pls_golite062009
procollagen-proline dioxygenase activity	0.482467028485988	bayes_pls_golite062009
peptidyl-proline dioxygenase activity	0.482467028485988	bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity	0.482467028485988	bayes_pls_golite062009
transcription factor activity	0.374364600772076	bayes_pls_golite062009
protein binding	0.213899354841013	bayes_pls_golite062009
hydrolase activity	0.0640969351727338	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [254-308]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGSQRKLEDA KYNQLHHPLP KIMLGISVLL LFYVLAKYRK RIFNRSSKIV SIRED

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.508	a.4.1	Homeodomain-like
View	Download	0.365	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.549	a.157.1	Skp1 dimerisation domain-like
View	Download	0.337	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.307	a.157.1	Skp1 dimerisation domain-like
View	Download	0.303	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.284	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.278	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.269	d.55.1	Ribosomal protein L22
View	Download	0.269	d.54.1	Enolase N-terminal domain-like
View	Download	0.267	a.16.1	S15/NS1 RNA-binding domain
View	Download	0.262	a.2.10	Epsilon subunit of F1F0-ATP synthase C-terminal domain
View	Download	0.260	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.259	a.4.1	Homeodomain-like
View	Download	0.253	a.164.1	C-terminal domain of DFF45/ICAD (DFF-C domain)
View	Download	0.249	a.2.7	tRNA-binding arm
View	Download	0.246	a.30.1	ROP protein
View	Download	0.242	a.4.1	Homeodomain-like
View	Download	0.238	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.234	a.2.7	tRNA-binding arm
View	Download	0.232	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.225	a.161.1	beta-catenin-interacting protein ICAT
View	Download	0.225	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.214	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.207	a.37.1	A DNA-binding domain in eukaryotic transcription factors
View	Download	0.206	a.4.1	Homeodomain-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: