YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213027063
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. 404ty
Length:	431 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213027063.

Description	E-value	Query Range	Subject Range
gi\|192927182, gi... - gi\|75256772\|ref\|ZP_00728377.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E22],... gi\|75209956, gi\|... - gi\|75209956\|ref\|ZP_00710145.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B171]... gi\|75194619, gi\|... - gi\|75194619\|ref\|ZP_00704689.1\| COG0642: Signal transduction histidine kinase [Escherichia coli HS], ... gi\|209910870, gi... - gi\|209917611\|ref\|YP_002291695.1\| phosphate regulon sensor protein [Escherichia coli SE11], gi\|209910... gi\|157079009, gi... - gi\|75189467\|ref\|ZP_00702734.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E2437... gi\|218552962, gi... - gi\|218552962\|ref\|YP_002385875.1\| phosphate regulon sensor protein [Escherichia coli IAI1], gi\|218359...	2.0E-74	[1..431]	[1..431]
gi\|253774615, gi... - gi\|254287270\|ref\|YP_003053018.1\| sensory histidine kinase in two-component regulatory system with Ph... gi\|242376178, gi... - gi\|251783905\|ref\|YP_002998209.1\| hypothetical protein B21_00352 [Escherichia coli BL21], gi\|24237617... gi\|83585681, gi\|... - gi\|83585681\|ref\|ZP_00924323.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 101-1... gi\|253972368, gi... - gi\|254160467\|ref\|YP_003043575.1\| sensory histidine kinase in two-component regulatory system with Ph...	4.0E-74	[1..431]	[1..431]
gi\|197243078, gi... - gi\|197264823\|ref\|ZP_03164897.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. en... gi\|224582235, gi... - gi\|224582235\|ref\|YP_002636033.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. e... lcl\|NC_016856.1_... - [gene=phoR] [protein=phosphate regulon sensor protein] [protein_id=YP_005236087.1] [location=452247.... gi\|194406707, gi... - gi\|194448403\|ref\|YP_002044431.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteri... gi\|194470414, gi... - gi\|194470414\|ref\|ZP_03076398.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. en... gi\|195631736, gi... - gi\|195631736\|gb\|EDX50256.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|194442327, gi... - gi\|194442327\|ref\|YP_002039638.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. e... gi\|16418902, gi\|... - gi\|16763778\|ref\|NP_459393.1\| phosphate regulon sensor protein [Salmonella typhimurium LT2], gi\|16418... gi\|205333420, gi... - gi\|205333420\|gb\|EDZ20184.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|168240216, gi... - gi\|205340126\|gb\|EDZ26890.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|167551796, gi... - gi\|205323434\|gb\|EDZ11273.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|205329541, gi... - gi\|205329541\|gb\|EDZ16305.1\| phosphate regulon sensor protein PhoR [Salmonella enterica subsp. enteri... gi\|62126642, gi\|... - gi\|62179009\|ref\|YP_215426.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|238911468 - gi\|238911468\|ref\|ZP_04655305.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteric...	2.0E-72	[1..431]	[1..431]
gi\|56414447, gi\|... - gi\|56414447\|ref\|YP_151522.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enterica s... gi\|197094845, gi... - gi\|197363368\|ref\|YP_002143005.1\| phosphate regulon sensor protein [Salmonella enterica subsp. enteri...	3.0E-72	[1..431]	[1..431]
gi\|13359907, gi\|... - gi\|15829704\|ref\|NP_308477.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 str. Sakai],... gi\|13359907, gi\|... - gi\|15829704\|ref\|NP_308477.1\| PhoR [Escherichia coli O157:H7], gi\|13359907\|dbj\|BAB33873.1\| positive a... gi\|209744228, gi... - pir\|\|F85535 hypothetical protein phoR [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|217325530, gi... - gi\|217325530\|ref\|ZP_03441614.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|15800126, gi\|... - gi\|15800126\|ref\|NP_286138.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 EDL933], gi\|... gi\|195938539 - gi\|195938539\|ref\|ZP_03083921.1\| phosphate regulon sensor protein [Escherichia coli O157:H7 str. EC40... gi\|189377386, gi... - gi\|189377386\|gb\|EDU95802.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC5... gi\|168786238, gi... - gi\|189373469\|gb\|EDU91885.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC8... gi\|168783257, gi... - gi\|188999394\|gb\|EDU68380.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|209159660, gi... - gi\|209398260\|ref\|YP_002269038.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str... gi\|208737438, gi... - gi\|208823245\|ref\|ZP_03263563.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|208815881, gi... - gi\|208815881\|ref\|ZP_03257060.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|208727269, gi... - gi\|208807468\|ref\|ZP_03249805.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str.... gi\|168749853, gi... - gi\|188015838\|gb\|EDU53960.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168776303, gi... - gi\|187768310\|gb\|EDU32154.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|189362390, gi... - gi\|189362390\|gb\|EDU80809.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168761597, gi... - gi\|189368101\|gb\|EDU86517.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|168756933, gi... - gi\|189356011\|gb\|EDU74430.1\| phosphate regulon sensor protein PhoR [Escherichia coli O157:H7 str. EC4... gi\|254791578, gi... - gi\|254791578\|ref\|YP_003076415.1\| sensory histidine kinase in two-component regulatory system with Ph...	5.0E-72	[1..431]	[1..431]
gi\|81244300, gi\|... - gi\|82542889\|ref\|YP_406836.1\| phosphate regulon sensor protein [Shigella boydii Sb227], gi\|81244300\|g... gi\|24050565, gi\|... - gi\|24111778\|ref\|NP_706288.1\| phosphate regulon sensor protein [Shigella flexneri 2a str. 301], gi\|24... gi\|30040140, gi\|... - gi\|30061896\|ref\|NP_836067.1\| phosphate regulon sensor protein [Shigella flexneri 2a str. 2457T], gi\|... gi\|110613971, gi... - gi\|110804423\|ref\|YP_687943.1\| phosphate regulon sensor protein [Shigella flexneri 5 str. 8401], gi\|1...	6.0E-72	[1..431]	[1..431]
gi\|169887821, gi... - gi\|170079986\|ref\|YP_001729306.1\| sensory histidine kinase in two-component regulatory system with Ph... gi\|89107270, gi\|... - gi\|89107270\|ref\|AP_001050.1\| sensory histidine kinase in two-component regulatory system with PhoB [... gi\|16209156 - gi\|16209156\|gb\|AAL09903.1\| PhoR+ [CRIM plasmid pAH152] EG10733 - sensory histidine kinase in two-component regulatory system with PhoB / Sensor histidine kinase /phos... gi\|16209169 - gi\|16209169\|gb\|AAL09907.1\| PhoR[Ec] [CRIM plasmid pAH156] EG10733 - sensory histidine kinase in two-component regulatory system with PhoB / Sensor histidine kinase /phos... gi\|238899688, gi... - gi\|238899688\|ref\|YP_002925484.1\| sensory histidine kinase in two-component regulatory system with Ph... PHOR_ECOLI - Phosphate regulon sensor protein phoR (EC 2.7.13.3) - Escherichia coli	7.0E-72	[1..431]	[1..431]
gi\|188493157, gi... - gi\|75512461\|ref\|ZP_00735000.1\| COG0642: Signal transduction histidine kinase [Escherichia coli 53638...	8.0E-72	[1..431]	[1..431]
gi\|75238727, gi\|... - gi\|75238727\|ref\|ZP_00722715.1\| COG0642: Signal transduction histidine kinase [Escherichia coli F11],... gi\|110640661, gi... - gi\|110640661\|ref\|YP_668389.1\| phosphate regulon sensor protein [Escherichia coli 536], gi\|110342253\|...	1.0E-71	[1..431]	[1..431]
gi\|218688262, gi... - gi\|218688262\|ref\|YP_002396474.1\| phosphate regulon sensor protein [Escherichia coli ED1a], gi\|218425... gi\|218557309, gi... - gi\|218557309\|ref\|YP_002390222.1\| phosphate regulon sensor protein [Escherichia coli S88], gi\|2183640... gi\|227884594, gi... - gi\|227884594\|ref\|ZP_04002399.1\| PAS/PAC sensor signal transduction histidine kinase [Escherichia col... gi\|218368682, gi... - gi\|218698696\|ref\|YP_002406325.1\| phosphate regulon sensor protein [Escherichia coli IAI39], gi\|21836... gi\|237707607, gi... - gi\|237707607\|ref\|ZP_04538088.1\| phosphate regulon sensor protein phoR [Escherichia sp. 3_2_53FAA], g... gi\|218350592, gi... - gi\|218693860\|ref\|YP_002401527.1\| phosphate regulon sensor protein [Escherichia coli 55989], gi\|21835... gi\|26246404, gi\|... - gi\|26246404\|ref\|NP_752443.1\| phosphate regulon sensor protein [Escherichia coli CFT073], gi\|26106802... gi\|194419136, gi... - gi\|83570332\|ref\|ZP_00921777.1\| COG0642: Signal transduction histidine kinase [Shigella dysenteriae 1... gi\|75230125, gi\|... - gi\|75230125\|ref\|ZP_00716629.1\| COG0642: Signal transduction histidine kinase [Escherichia coli B7A],... gi\|75237219, gi\|... - gi\|75237219\|ref\|ZP_00721266.1\| COG0642: Signal transduction histidine kinase [Escherichia coli E1100...	1.0E-71	[1..431]	[1..431]

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Predicted Domain #1

Region A:
Residues: [1-182]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLERLSWKRL VLELVLCCIP ALILSAFFGY LPWFLLAAVT GLLVWHFWNL LRLSWWLWVD  60
   61 RSMTPPPGRG SWEPLLYGLH QMQLRNKKRR RELGNLIKRF RSGAESLPDA VVLTTEEGGI 120
  121 FWCNGLAQQI LGLRWPDDNG QNILNLLRYP EFTQYLKTRD FTRPLHLVLN TGRHLEIRVM 180
  181 PY

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.98
Match:	1v9yA
Description:	Crystal Structure of the heme PAS sensor domain of Ec DOS (ferric form)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ion transmembrane transporter activity	1.81312487233411	bayes_pls_golite062009
binding	1.67984576110273	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.60314341650446	bayes_pls_golite062009
two-component response regulator activity	1.41577088905201	bayes_pls_golite062009
cation transmembrane transporter activity	1.40823491489039	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.10325694432704	bayes_pls_golite062009
transcription regulator activity	0.931375605669218	bayes_pls_golite062009
protein binding	0.888256242702267	bayes_pls_golite062009
voltage-gated ion channel activity	0.563198063703829	bayes_pls_golite062009
potassium channel activity	0.563028071397075	bayes_pls_golite062009
voltage-gated channel activity	0.552480950289765	bayes_pls_golite062009
voltage-gated cation channel activity	0.551619757281389	bayes_pls_golite062009
DNA binding	0.533187513797767	bayes_pls_golite062009
voltage-gated potassium channel activity	0.532581714382914	bayes_pls_golite062009
ion channel activity	0.483348490364346	bayes_pls_golite062009
two-component sensor activity	0.466388018187262	bayes_pls_golite062009
protein histidine kinase activity	0.452475261443277	bayes_pls_golite062009
cation channel activity	0.445728116294453	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.409938237891918	bayes_pls_golite062009
substrate-specific channel activity	0.391671932145714	bayes_pls_golite062009
passive transmembrane transporter activity	0.388177774524707	bayes_pls_golite062009
channel activity	0.388177774524707	bayes_pls_golite062009
nucleic acid binding	0.387046112137798	bayes_pls_golite062009
gated channel activity	0.383085563903689	bayes_pls_golite062009
signal transducer activity	0.341738261779128	bayes_pls_golite062009
molecular transducer activity	0.341738261779128	bayes_pls_golite062009
catalytic activity	0.335650048048265	bayes_pls_golite062009
transporter activity	0.308330515689802	bayes_pls_golite062009
transcription factor activity	0.15709070306709	bayes_pls_golite062009
transmembrane transporter activity	0.154730712374367	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [183-431]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDKQLLMVAR DVTQMHQLEG ARRNFFANVS HELRTPLTVL QGYLEMMQEQ ALEGATREKA  60
   61 LHTMREQTYR MEGLVKQLLT LSKIEVAPAL LLNEKVDVPM MLRVVEREAQ TLSQQKHTFT 120
  121 FAVDDSLSVL GNEEQLRSAI SNLVYNAVNH TPAGTHITVS WRRAAHGAEF CIQDNGPGIA 180
  181 AEHIPRLTER FYRVDKARSR QTGGSGLGLA IVKHALNHHE SRLEIDSSPG KGTRFSFVLP 240
  241 ERLIAKNSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	50.045757
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: