YRC Public Data Repository - Protein Structure Prediction

Protein:	MUTS_ECODH
Organism:	Escherichia coli str. K-12 substr. DH10B
Length:	853 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MUTS_ECODH.

Description	E-value	Query Range	Subject Range
MUTS_ERWCT - DNA mismatch repair protein mutS OS=Erwinia carotovora subsp. atroseptica GN=mutS PE=3 SV=1 MUTS_PECAS - DNA mismatch repair protein MutS OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN...	946.0	[0..6]	[853..8]
gi\|205324663, gi... - gi\|205324663\|gb\|EDZ12502.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|167993148, gi... - gi\|205328749\|gb\|EDZ15513.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... gi\|168242649, gi... - gi\|205338197\|gb\|EDZ24961.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALCH - DNA mismatch repair protein MutS OS=Salmonella choleraesuis (strain SC-B67) GN=mutS PE=3 SV=1 lcl\|NC_016856.1_... - [gene=mutS] [protein=DNA mismatch repair protein] [protein_id=YP_005239020.1] [location=3070516..307... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALCH - DNA mismatch repair protein mutS OS=Salmonella choleraesuis GN=mutS PE=3 SV=1 MUTS_SALTI - DNA mismatch repair protein MutS OS=Salmonella typhi GN=mutS PE=3 SV=1 MUTS_SALG2 - DNA mismatch repair protein MutS OS=Salmonella gallinarum (strain 287/91 / NCTC 13346) GN=mutS PE=3 ... MUTS_SALTY - DNA mismatch repair protein MutS OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=... gi\|213854165 - gi\|213854165\|ref\|ZP_03382697.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica ser... MUTS_SALTY - DNA mismatch repair protein mutS OS=Salmonella typhimurium GN=mutS PE=1 SV=1 MUTS_SALPB - DNA mismatch repair protein mutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALPB - DNA mismatch repair protein MutS OS=Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) GN=mutS PE=... MUTS_SALTI - DNA mismatch repair protein mutS OS=Salmonella typhi GN=mutS PE=3 SV=1 gi\|168463951, gi... - gi\|195633763\|gb\|EDX52177.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enterica se... MUTS_SALHS - DNA mismatch repair protein MutS OS=Salmonella heidelberg (strain SL476) GN=mutS PE=3 SV=1 gi\|29143167, gi\|... - gi\|29143167\|ref\|NP_806509.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... MUTS_SALA4 - DNA mismatch repair protein MutS OS=Salmonella agona (strain SL483) GN=mutS PE=3 SV=1 gi\|16761683 - gi\|16761683\|ref\|NP_457300.1\| DNA mismatch repair protein [Salmonella enterica subsp. enterica serova... gi\|197240275, gi... - gi\|197262020\|ref\|ZP_03162094.1\| DNA mismatch repair protein MutS [Salmonella enterica subsp. enteric...	944.0	[0..5]	[853..7]
MUTS_SALPA - DNA mismatch repair protein mutS OS=Salmonella paratyphi A GN=mutS PE=3 SV=1 MUTS_SALPA - DNA mismatch repair protein MutS OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=mutS PE=3 ...	943.0	[0..5]	[853..7]
gi\|190908438, gi... - gi\|191171138\|ref\|ZP_03032688.1\| DNA mismatch repair protein MutS [Escherichia coli F11], gi\|19090843... MUTS_ECOL5 - DNA mismatch repair protein MutS OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=mutS PE=3 SV=...	934.0	[0..1]	[853..1]
MUTS_PHOLL - DNA mismatch repair protein mutS OS=Photorhabdus luminescens subsp. laumondii GN=mutS PE=3 SV=1 MUTS_PHOLL - DNA mismatch repair protein MutS OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CI...	933.0	[0..1]	[853..1]
gi\|227888273, gi... - gi\|227888273\|ref\|ZP_04006078.1\| DNA mismatch repair protein [Escherichia coli 83972], gi\|227834542\|g... MUTS_ECOL6 - DNA mismatch repair protein mutS OS=Escherichia coli O6 GN=mutS PE=3 SV=1 MUTS_ECOL6 - DNA mismatch repair protein MutS OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=m...	930.0	[0..1]	[853..1]
MUTS_ECO45 - DNA mismatch repair protein MutS OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mutS PE=3 SV=1 MUTS_ECOK1 - DNA mismatch repair protein MutS OS=Escherichia coli O1:K1 / APEC GN=mutS PE=3 SV=1 gi\|237706641, gi... - gi\|237706641\|ref\|ZP_04537122.1\| DNA mismatch repair protein mutS [Escherichia sp. 3_2_53FAA], gi\|226... MUTS_ECOUT - DNA mismatch repair protein MutS OS=Escherichia coli (strain UTI89 / UPEC) GN=mutS PE=3 SV=1	930.0	[0..1]	[853..1]
gi\|157156430, gi... - gi\|75187457\|ref\|ZP_00700724.1\| COG0249: Mismatch repair ATPase (MutS family) [Escherichia coli E2437...	929.0	[0..5]	[853..12]
gi\|254594075, gi... - gi\|254794675\|ref\|YP_003079512.1\| methyl-directed mismatch repair protein [Escherichia coli O157:H7 s... gi\|208739537, gi... - gi\|208819414\|ref\|ZP_03259734.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC40... gi\|208735412, gi... - gi\|208814135\|ref\|ZP_03255464.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC40... MUTS_ECO8A - DNA mismatch repair protein MutS OS=Escherichia coli O8 (strain IAI1) GN=mutS PE=3 SV=1 MUTS_ECO5E - DNA mismatch repair protein MutS OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=mutS PE=3 SV=... gi\|192957000, gi... - gi\|193069637\|ref\|ZP_03050589.1\| DNA mismatch repair protein MutS [Escherichia coli E110019], gi\|1929... gi\|191166787, gi... - gi\|191166787\|ref\|ZP_03028613.1\| DNA mismatch repair protein MutS [Escherichia coli B7A], gi\|19090315... gi\|208807935, gi... - gi\|208807935\|ref\|ZP_03250272.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC42... gi\|195938486 - gi\|195938486\|ref\|ZP_03083868.1\| DNA mismatch repair protein [Escherichia coli O157:H7 str. EC4024] gi\|15832843, gi\|... - gi\|15832843\|ref\|NP_311616.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. Sakai],... gi\|168787991, gi... - gi\|189372119\|gb\|EDU90535.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC869], ... gi\|168778718, gi... - gi\|189003145\|gb\|EDU72131.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4076],... gi\|188493251, gi... - gi\|188493251\|ref\|ZP_03000521.1\| DNA mismatch repair protein MutS [Escherichia coli 53638], gi\|188488... gi\|189377459, gi... - gi\|189377459\|gb\|EDU95875.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC508], ... gi\|189357264, gi... - gi\|189357264\|gb\|EDU75683.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4401],... gi\|188015814, gi... - gi\|188015814\|gb\|EDU53936.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4113],... gi\|168774732, gi... - gi\|187769600\|gb\|EDU33444.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4196],... gi\|168768827, gi... - gi\|189362111\|gb\|EDU80530.1\| DNA mismatch repair protein MutS [Escherichia coli O157:H7 str. EC4486],... MUTS_ECO57 - DNA mismatch repair protein MutS OS=Escherichia coli O157:H7 GN=mutS PE=3 SV=1 gi\|25317150, gi\|... - gi\|4887554\|emb\|CAB43497.1\| mismatch repair protein [Escherichia coli], pir\|\|E91077 MutS protein [imp...	929.0	[0..1]	[853..1]
gi\|12517186, gi\|... - gi\|15803252\|ref\|NP_289284.1\| DNA mismatch repair protein [Escherichia coli O157:H7 EDL933], gi\|12517... gi\|25317161 - gi\|25317161\|pir\|\|F85922 methyl-directed mismatch repair [imported] - Escherichia coli (strain O157:H...	928.0	[0..1]	[853..1]

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Predicted Domain #1

Region A:
Residues: [1-853]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA  60
   61 SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS 120
  121 DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY 180
  181 AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL 240
  241 LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT 300
  301 PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA 360
  361 RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR 420
  421 DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG 480
  481 QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE 540
  541 ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP 600
  601 LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA 660
  661 DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK 720
  721 ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG 780
  781 VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR 840
  841 QALEWIYRLK SLV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1e3mA
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
mismatched DNA binding	7.6300905919597	bayes_pls_golite062009
	6.67853997762091	bayes_pls_golite062009
guanine/thymine mispair binding	6.45283004617788	bayes_pls_golite062009
DNA insertion or deletion binding	6.26024791706598	bayes_pls_golite062009
single base insertion or deletion binding	5.15853852267378	bayes_pls_golite062009
dinucleotide insertion or deletion binding	4.09431251446007	bayes_pls_golite062009
oxidized purine DNA binding	3.84835351634579	bayes_pls_golite062009
oxidized DNA binding	3.84835351634579	bayes_pls_golite062009
single guanine insertion binding	3.84835351634579	bayes_pls_golite062009
DNA secondary structure binding	3.18179842526435	bayes_pls_golite062009
dinucleotide repeat insertion binding	3.17347240690102	bayes_pls_golite062009
loop DNA binding	3.13510929288157	bayes_pls_golite062009
mismatch repair complex binding	2.99730753457176	bayes_pls_golite062009
single thymine insertion binding	2.28303894489307	bayes_pls_golite062009
four-way junction DNA binding	2.23712359726448	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.16381244011837	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.11265775498161	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.11046854230259	bayes_pls_golite062009
double-strand/single-strand DNA junction binding	1.91034220759707	bayes_pls_golite062009
MutLalpha complex binding	1.83584397705627	bayes_pls_golite062009
hydrolase activity	1.66122526893602	bayes_pls_golite062009
binding	1.62320027057768	bayes_pls_golite062009
ATPase activity	1.53315090215319	bayes_pls_golite062009
DNA-dependent ATPase activity	1.1653223755451	bayes_pls_golite062009
Y-form DNA binding	1.0681332518071	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA helicase activity	0.8104901979223	bayes_pls_golite062009
helicase activity	0.701689608967233	bayes_pls_golite062009
nucleic acid binding	0.503971340374059	bayes_pls_golite062009
structure-specific DNA binding	0.269513772401086	bayes_pls_golite062009
ATP-dependent helicase activity	0.146865639513637	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.146865639513637	bayes_pls_golite062009
double-stranded DNA binding	0.11598665103566	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
DNA binding	0.111331583742205	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: