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View Structure Prediction Details

Protein: gi|190689913, gi...
Organism: synthetic construct
Length: 463 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190689913, gi....

Description E-value Query
Range
Subject
Range
gi|109019327, gi... - gi|109019327|ref|XP_001085313.1| PREDICTED: retinoid X receptor, gamma isoform 3 [Macaca mulatta], g...
0.0 [1..463] [1..463]
gi|55726030 - gi|55726030|emb|CAH89791.1| hypothetical protein [Pongo abelii]
RXRG_PONAB - Retinoic acid receptor RXR-gamma OS=Pongo abelii GN=RXRG PE=2 SV=1
0.0 [1..463] [1..463]
RXRG_BOVIN - Retinoic acid receptor RXR-gamma OS=Bos taurus GN=RXRG PE=2 SV=1
0.0 [1..463] [1..463]
gi|74006096 - gi|74006096|ref|XP_536146.2| PREDICTED: similar to Retinoic acid receptor RXR-gamma (Retinoid X rece...
0.0 [1..463] [1..463]
RXRG_RAT - Retinoic acid receptor RXR-gamma OS=Rattus norvegicus GN=Rxrg PE=2 SV=1
0.0 [1..463] [1..463]
gi|386367 - gi|386367|gb|AAB27244.1| retinoid-X receptor-gamma isoform 1; mRXR gamma 1 [Mus sp.]
RXRG_MOUSE - Retinoic acid receptor RXR-gamma OS=Mus musculus GN=Rxrg PE=2 SV=2
0.0 [1..463] [1..463]
gi|194332487, gi... - gi|194332487|ref|NP_001123685.1| retinoid X receptor, gamma [Sus scrofa], gi|112820329|gb|ABI24018.1...
0.0 [1..463] [1..463]
gi|114561089 - gi|114561089|ref|XP_001174549.1| PREDICTED: retinoid X receptor, gamma isoform 1 [Pan troglodytes]
0.0 [1..463] [1..469]

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Predicted Domain #1
Region A:
Residues: [1-130]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYGNYSHFMK FPAGYGGSPG HTGSTSMSPS AALSTGKPMD SHPSYTDTPV SAPRTLSAVG  60
   61 TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG 120
  121 IGNMNYPSTS 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.43
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #2
Region A:
Residues: [131-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR  60
   61 CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1ynwB
Description: Crystal Structure of Vitmain D Receptor and 9-cis Retinoic Acid Receptor DNA-Binding Domains Bound to a DR3 Response Element
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [226-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CATSGHEDMP VERILEAELA VEPKTESYGD MNMENSTNDP VTNICHAADK QLFTLVEWAK  60
   61 RIPHFSDLTL EDQVILLRAG WNELLIASFS HRSVSVQDGI LLATGLHVHR SSAHSAGVGS 120
  121 IFDRVLTELV SKMKDMQMDK SELGCLRAIV LFNPDAKGLS NPSEVETLRE KVYATLEAYT 180
  181 KQKYPEQPGR FAKLLLRLPA LRSIGLKCLE HLFFFKLIGD TPIDTFLMEM LETPLQIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.154902
Match: 1lbdA
Description: LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.53061626347066 bayes_pls_golite062009
DNA binding 4.92165988569962 bayes_pls_golite062009
steroid hormone receptor activity 4.81441024181511 bayes_pls_golite062009
nucleic acid binding 4.78024150262074 bayes_pls_golite062009
transcription activator activity 4.53302455129434 bayes_pls_golite062009
sequence-specific DNA binding 4.11614358606713 bayes_pls_golite062009
transcription factor activity 4.0914094580319 bayes_pls_golite062009
nuclear hormone receptor binding 3.91470119037087 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 3.89763470197726 bayes_pls_golite062009
binding 3.85318710398432 bayes_pls_golite062009
transcription repressor activity 3.83878598697109 bayes_pls_golite062009
hormone receptor binding 3.79647267365529 bayes_pls_golite062009
molecular transducer activity 3.57626193382263 bayes_pls_golite062009
signal transducer activity 3.57626193382263 bayes_pls_golite062009
protein binding 3.21524787168952 bayes_pls_golite062009
transcription activator binding 2.98235973123409 bayes_pls_golite062009
estrogen receptor activity 2.84886725099086 bayes_pls_golite062009
transcription factor binding 2.68044489404568 bayes_pls_golite062009
receptor activity 2.62895787183554 bayes_pls_golite062009
ecdysteroid hormone receptor activity 2.54335605534182 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.38308182853979 bayes_pls_golite062009
transcription coactivator activity 2.27959329058894 bayes_pls_golite062009
hormone binding 2.22128813425565 bayes_pls_golite062009
transcription cofactor activity 1.73827483890179 bayes_pls_golite062009
structure-specific DNA binding 1.70383793233433 bayes_pls_golite062009
retinoic acid receptor binding 1.59968001933699 bayes_pls_golite062009
estrogen response element binding 1.56094639526803 bayes_pls_golite062009
double-stranded DNA binding 1.48246587604476 bayes_pls_golite062009
retinoid X receptor binding 1.45560845709347 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.34794228300778 bayes_pls_golite062009
promoter binding 1.28787959668198 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 1.23181585568439 bayes_pls_golite062009
transcription corepressor activity 0.995333369475571 bayes_pls_golite062009
steroid binding 0.933060984463406 bayes_pls_golite062009
retinoic acid receptor activity 0.853869057774515 bayes_pls_golite062009
protein dimerization activity 0.797229273848179 bayes_pls_golite062009
steroid hormone receptor binding 0.754240851368212 bayes_pls_golite062009
retinoic acid binding 0.676688935879073 bayes_pls_golite062009
protein N-terminus binding 0.57701453824007 bayes_pls_golite062009
thyroid hormone receptor activity 0.49784404390361 bayes_pls_golite062009
lipid binding 0.475303782949439 bayes_pls_golite062009
protein heterodimerization activity 0.45265806678057 bayes_pls_golite062009
vitamin D3 receptor activity 0.428420599209378 bayes_pls_golite062009
receptor binding 0.418843034756825 bayes_pls_golite062009
androgen receptor activity 0.399730816072004 bayes_pls_golite062009
ligand-regulated transcription factor activity 0.202197503742221 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.15737167800277 bayes_pls_golite062009
catalytic activity 0.106902059021677 bayes_pls_golite062009
androgen binding 0.0219623894804069 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle