YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190409582
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	688 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190409582.

Description	E-value	Query Range	Subject Range
YMR1 - Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, i... YMR1_YEAST - Phosphoinositide 3-phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMR1 PE=1... gi\|190409582 - gi\|190409582\|gb\|EDV12847.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] gi\|207343784 - gi\|207343784\|gb\|EDZ71137.1\| YJR110Wp-like protein [Saccharomyces cerevisiae AWRI1631]	0.0	[1..688]	[1..688]
MTMR2_MOUSE, MTR... - (Q9Z2D1) Myotubularin-related protein 2 (EC 3.1.3.-), Myotubularin-related protein 2 OS=Mus musculus...	0.0	[2..668]	[82..620]
MTMR8 - myotubularin related protein 8	0.0	[1..666]	[1..524]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI YGVHKNPGST  60
   61 LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK DYAVFSLDFG GDLHLQARKV 120
  121 YDSILNLTVL SNITQLYAFI YISNNLERKL PSPDSWDIYD PIKEFRRQGL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
phosphatase activity	7.03758345564381	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.82821455971597	bayes_pls_golite062009
phosphoprotein phosphatase activity	6.3275802559101	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.83769298632658	bayes_pls_golite062009
protein tyrosine phosphatase activity	4.98117543861822	bayes_pls_golite062009
lipid phosphatase activity	4.03975183132282	bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity	2.71515178944974	bayes_pls_golite062009
transmembrane receptor protein phosphatase activity	2.71515178944974	bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity	2.60529675907066	bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity	2.5359729064152	bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity	2.05577133553311	bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	1.72084618199574	bayes_pls_golite062009
protein serine/threonine phosphatase activity	1.68447406212301	bayes_pls_golite062009
hydrolase activity	1.64178855997223	bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity	1.51576958903553	bayes_pls_golite062009
binding	1.42026750513729	bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity	1.1200449509328	bayes_pls_golite062009
protein binding	1.07441758584517	bayes_pls_golite062009
catalytic activity	1.06283028154109	bayes_pls_golite062009
kinase activity	0.541255358115631	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.532875179381704	bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity	0.502994448655937	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.359793029026564	bayes_pls_golite062009
GTPase regulator activity	0.355387992614734	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.335498703113274	bayes_pls_golite062009
transmembrane receptor activity	0.291525352733402	bayes_pls_golite062009
receptor activity	0.191946218805025	bayes_pls_golite062009
transferase activity	0.05073595579848	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [171-688]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSKDETCPWR LSTVNEHYEF CPTYPSKLFV PRSTSDILLK HASKFRSQKR IPVLTYHHKA  60
   61 TDCNILRSSQ PLPGLINQRS IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA 120
  121 LGGGTENMDN YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD 180
  181 LNLPLEQNLI RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG WDRTSQVVSL 240
  241 LEICLDPFYR TFEGFMILVE KDWCSFGHRF LERSGHLNSD IRFHDNTMHS NFNDVDTNGD 300
  301 DLDIGVNTQD DYAEDDEGGE DETNLINLSR ISKKFNENFK LNKKSLKFVS PVFQQFLDCV 360
  361 YQLLTQNPDL FEFNERFLRR LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR 420
  421 RKQFINPNFI QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH 480
  481 KRDSVPISVD KKSKEHSNSD GGKGLNLSIF GFDMFNRK