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View Structure Prediction Details

Protein: gi|208967719, gi...
Organism: synthetic construct
Length: 971 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|208967719, gi....

Description E-value Query
Range		 Subject
Range
XPO2_ORENI - Exportin-2 OS=Oreochromis niloticus GN=cse1l PE=2 SV=1
 0.0 [1..971] [1..971]
XPO2_MOUSE - Exportin-2 OS=Mus musculus GN=Cse1l PE=1 SV=1
 0.0 [1..971] [1..971]
XPO2_PONPY - Exportin-2 - Pongo pygmaeus (Orangutan)
XPO2_PONAB - Exportin-2 OS=Pongo abelii GN=CSE1L PE=2 SV=1
 0.0 [1..971] [1..971]
gi|3560557 - gi|3560557|gb|AAC35008.1| cellular apoptosis susceptibility protein [Homo sapiens]
 0.0 [1..971] [1..971]
gi|149042854, gi... - gi|34860723|ref|XP_342582.1| PREDICTED: similar to chromosome segregation 1-like [Rattus norvegicus]...
 0.0 [1..971] [1..971]
XPO2_PAGMA - Exportin-2 OS=Pagrus major GN=cse1l PE=2 SV=1
 0.0 [1..971] [1..971]
XPO2_XENLA - Exportin-2 OS=Xenopus laevis GN=cse1l PE=2 SV=1
 0.0 [1..971] [1..971]
XPO2_DANRE - Exportin-2 OS=Danio rerio GN=cse1l PE=2 SV=1
 0.0 [1..971] [1..971]
gi|109091665 - gi|109091665|ref|XP_001100361.1| PREDICTED: similar to CSE1 chromosome segregation 1-like protein is...
gi|114682543 - gi|114682543|ref|XP_001165837.1| PREDICTED: CSE1 chromosome segregation 1-like protein isoform 1 [Pa...
 0.0 [1..971] [1..962]

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Predicted Domain #1
Region A:
Residues: [1-971] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV  60
   61 CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR 120
  121 EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF 180
  181 ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN 240
  241 NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL 300
  301 LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE 360
  361 AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP 420
  421 SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL 480
  481 KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL 540
  541 FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ 600
  601 KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI 660
  661 PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA 720
  721 SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN 780
  781 SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK 840
  841 ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ 900
  901 TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ 960
  961 GYLQAASVTL L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 132.0
Match: 1z3hA
Description: The exportin Cse1 in its cargo-free, cytoplasmic state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 4.58709163830613 bayes_pls_golite062009
nuclear export signal receptor activity 3.48172991171337 bayes_pls_golite062009
binding 3.0667965351474 bayes_pls_golite062009
protein transmembrane transporter activity 2.74547353635661 bayes_pls_golite062009
transporter activity 2.48700774379895 bayes_pls_golite062009
nucleic acid binding 2.34284977509828 bayes_pls_golite062009
substrate-specific transporter activity 2.26725422172281 bayes_pls_golite062009
nuclear localization sequence binding 1.91487015967262 bayes_pls_golite062009
transcription regulator activity 1.76231475025891 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
DNA binding 1.62032607987786 bayes_pls_golite062009
transmembrane transporter activity 1.28481004323799 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 1.09652988954158 bayes_pls_golite062009
transcription factor activity 0.923253759652909 bayes_pls_golite062009
structural molecule activity 0.908029258648777 bayes_pls_golite062009
translation initiation factor activity 0.83079633551839 bayes_pls_golite062009
translation regulator activity 0.82193201542158 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.803700928110921 bayes_pls_golite062009
clathrin binding 0.70539170437469 bayes_pls_golite062009
molecular transducer activity 0.662662274021266 bayes_pls_golite062009
signal transducer activity 0.662662274021266 bayes_pls_golite062009
signal sequence binding 0.57106697498903 bayes_pls_golite062009
mRNA binding 0.46864854653143 bayes_pls_golite062009
RNA binding 0.40024158562931 bayes_pls_golite062009
importin-alpha export receptor activity 0.259676026705859 bayes_pls_golite062009
active transmembrane transporter activity 0.252495966234234 bayes_pls_golite062009
ion transmembrane transporter activity 0.248585912061178 bayes_pls_golite062009
primary active transmembrane transporter activity 0.226380819487924 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.217517113570989 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.178770060806735 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.175241020572885 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.174922130116569 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.100181463251306 bayes_pls_golite062009
pyrophosphatase activity 0.0635404099346928 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0548082069333885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.052195223119721 bayes_pls_golite062009
cation transmembrane transporter activity 0.0405268469927988 bayes_pls_golite062009
transcription activator activity 0.0232727461674547 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle