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View Structure Prediction Details

Protein: gi|224502886
Organism: Listeria monocytogenes FSL R2-561
Length: 579 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|224502886.

Description E-value Query
Range		 Subject
Range
gi|75702277, gi|... - gi|75908552|ref|YP_322848.1| ATPase [Anabaena variabilis ATCC 29413], gi|75702277|gb|ABA21953.1| ATP...
 377.0 [0..4] [579..168]
CLPB2_ORYSJ - Chaperone protein ClpB2, chloroplastic OS=Oryza sativa subsp. japonica GN=CLPB2 PE=2 SV=1
 377.0 [0..5] [579..250]
gi|17232576, gi|... - gi|17232576|ref|NP_489124.1| endopeptidase Clp ATP-binding chain B [Nostoc sp. PCC 7120], gi|1713422...
gi|25289937 - pir||AD2441 endopeptidase Clp ATP-binding chain B [imported] - Nostoc sp. (strain PCC 7120)
 375.0 [0..4] [579..131]
CLPB_GLOVI - Chaperone protein ClpB OS=Gloeobacter violaceus GN=clpB PE=3 SV=1
CLPB_GLOVI - Chaperone protein ClpB OS=Gloeobacter violaceus (strain PCC 7421) GN=clpB PE=3 SV=1
 373.0 [0..4] [579..169]
CLPB3_ARATH - Chaperone protein ClpB3, chloroplastic OS=Arabidopsis thaliana GN=CLPB3 PE=2 SV=1
 372.0 [0..5] [579..243]
CLPB1_SYNEL, CLB... - Chaperone protein clpB 1 OS=Synechococcus elongatus GN=clpB1 PE=3 SV=1, (Q8DJ40) Chaperone clpB 1
CLPB1_THEEB - Chaperone protein ClpB 1 OS=Thermosynechococcus elongatus (strain BP-1) GN=clpB1 PE=3 SV=1
 369.0 [0..4] [579..167]
CLPB_LEPBY - Chaperone protein ClpB OS=Leptolyngbya boryana GN=clpB PE=2 SV=2
 369.0 [0..4] [579..169]

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Predicted Domain #1
Region A:
Residues: [1-197] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYQALYRVF RPQSFQDVVG QEHVTKTLKN AIVQNKTSHA YLFSGPRGTG KTSAAKIFAK  60
   61 AINCEHGHDG EPCNECEICK GTTDGSIPDV LEIDAASNNG VEEIRDIREK VKYAPTVAKY 120
  121 KVYIIDEVHM LSTGAFNALL KTLEEPPKHV IFILATTEPH KLPLTIISRV QRFDFKRITT 180
  181 QDIIGRLKFI LEEEKIP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.69897
Match: 1xxiB
Description: ADP Bound E. coli Clamp Loader Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 6.51495346697904 bayes_pls_golite062009
protein-DNA loading ATPase activity 6.40748863504898 bayes_pls_golite062009
DNA-directed DNA polymerase activity 6.09279996112705 bayes_pls_golite062009
DNA polymerase activity 6.04865791514294 bayes_pls_golite062009
nucleotidyltransferase activity 3.99580940620614 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
mismatched DNA binding 2.51625633651862 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.85506769032946 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.77451606086272 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
guanine/thymine mispair binding 1.69026972999845 bayes_pls_golite062009
DNA insertion or deletion binding 1.68890613599528 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
transferase activity 1.23626141560528 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
microtubule motor activity 1.1277447806079 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
transcription regulator activity 0.748437190903548 bayes_pls_golite062009
single base insertion or deletion binding 0.629563765934841 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
double-strand/single-strand DNA junction binding 0.0136229525922795 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-579] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDEKALMIVA RAAEGGMRDA LSLLDQVISY GSEEVTVEDA LEITGSVAQN LLTKLVSAAF  60
   61 DGDAAEAIST LTALLAEGKD PVRLVEDLLV FFRDVLLYQK APNLEETMER ALIDDDFVAL 120
  121 AKRADSLKVY EFVKILNTAQ QQMRFSNHPG IYVEVALVQL TQAGQSVAGG GNVPADAASG 180
  181 SDVSDLKRQM EQMHQEIQTL KKQIASGAGA APADKPTQNR GGSKKAINNG KQFKAPIGKI 240
  241 NHVLGEAKKE NLQLIRGCWG ELLSMLMASQ AALLNDAEPV AASQDTFVLK FKHEIHCQMA 300
  301 MDNPNFVETI TSSIARLTQV NYTFIGIPED QWADVRENFL HSHGSDADAE DGANPEAKKP 360
  361 AEDPFVAEAA KLVGEDLLEI KD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.39794
Match: 1ksfX
Description: N-terminal, ClpS-binding domain of ClpA, an Hsp100 chaperone; ClpA, an Hsp100 chaperone, AAA+ modules
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 6.51495346697904 bayes_pls_golite062009
protein-DNA loading ATPase activity 6.40748863504898 bayes_pls_golite062009
DNA-directed DNA polymerase activity 6.09279996112705 bayes_pls_golite062009
DNA polymerase activity 6.04865791514294 bayes_pls_golite062009
nucleotidyltransferase activity 3.99580940620614 bayes_pls_golite062009
DNA-dependent ATPase activity 2.72462789867829 bayes_pls_golite062009
binding 2.64537357529343 bayes_pls_golite062009
mismatched DNA binding 2.51625633651862 bayes_pls_golite062009
DNA helicase activity 2.2817164193758 bayes_pls_golite062009
pyrophosphatase activity 2.13284212711072 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.88455339138556 bayes_pls_golite062009
1.85506769032946 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.77451606086272 bayes_pls_golite062009
helicase activity 1.70242731830224 bayes_pls_golite062009
guanine/thymine mispair binding 1.69026972999845 bayes_pls_golite062009
DNA insertion or deletion binding 1.68890613599528 bayes_pls_golite062009
RNA helicase activity 1.63960194106079 bayes_pls_golite062009
ATP-dependent RNA helicase activity 1.61735400124552 bayes_pls_golite062009
RNA-dependent ATPase activity 1.60404584546501 bayes_pls_golite062009
nucleic acid binding 1.49633029954726 bayes_pls_golite062009
structure-specific DNA binding 1.2539059700735 bayes_pls_golite062009
transferase activity 1.23626141560528 bayes_pls_golite062009
purine NTP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
ATP-dependent helicase activity 1.19311444180077 bayes_pls_golite062009
motor activity 1.14667913749579 bayes_pls_golite062009
microtubule motor activity 1.1277447806079 bayes_pls_golite062009
double-stranded DNA binding 1.117585097627 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
DNA binding 0.967303417236485 bayes_pls_golite062009
transcription regulator activity 0.748437190903548 bayes_pls_golite062009
single base insertion or deletion binding 0.629563765934841 bayes_pls_golite062009
single-stranded DNA binding 0.568457189190858 bayes_pls_golite062009
cytoskeletal protein binding 0.500462538667228 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.147579541298736 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.113504049290503 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.111293884322157 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structural constituent of ribosome 0.089234257580272 bayes_pls_golite062009
3'-5' DNA helicase activity 0.0769112340058804 bayes_pls_golite062009
double-strand/single-strand DNA junction binding 0.0136229525922795 bayes_pls_golite062009
actin binding 0.00482938540552702 bayes_pls_golite062009
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Created and Maintained by: Michael Riffle