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View Structure Prediction Details

Protein: SPRC_PONAB
Organism: Pongo abelii
Length: 303 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPRC_PONAB.

Description E-value Query
Range
Subject
Range
gi|3411212 - gi|3411212|gb|AAD12179.1| osteonectin precursor [Coturnix coturnix]
SPRC_COTJA - SPARC OS=Coturnix coturnix japonica GN=SPARC PE=2 SV=1
0.0 [1..303] [1..298]
gi|61365991, gi|... - gi|61365991|gb|AAX42796.1| secreted protein acidic cysteine-rich [synthetic construct], gi|61365439|...
0.0 [1..303] [1..303]
SPRC_BOVIN - SPARC OS=Bos taurus GN=SPARC PE=1 SV=2
0.0 [1..303] [1..303]
gi|73954161 - gi|73954161|ref|XP_854982.1| PREDICTED: similar to SPARC precursor (Secreted protein acidic and rich...
0.0 [1..303] [1..303]
gi|27924266, gi|... - gi|76779918|gb|AAI06299.1| MGC53121 protein [Xenopus laevis], gi|27924266|gb|AAH45013.1| MGC53121 pr...
0.0 [1..303] [1..300]
gi|197102212 - gi|197102212|ref|NP_001127042.1| secreted protein, acidic, cysteine-rich (osteonectin) [Pongo abelii...
gi|55733613 - gi|55733613|emb|CAH93483.1| hypothetical protein [Pongo abelii]
0.0 [1..303] [1..303]
gi|50754911 - gi|50754911|ref|XP_429233.1| PREDICTED: hypothetical protein XP_429233 [Gallus gallus]
0.0 [1..303] [1..298]
SPRC_RAT - SPARC OS=Rattus norvegicus GN=Sparc PE=1 SV=4
0.0 [1..303] [1..301]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE  60
   61 E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [62-303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEEEVVAENP CQNHHCKHGK VCELDENNTP MCVCQDPTSC PAPIGEFEKV CSNDNKTFDS  60
   61 SCHFFATKCT LEGTKKGHKL HLDYIGPCKY IPPCLDSELT EFPLRMRDWL KNVLVTLYER 120
  121 DEDNNLLTEK QKLRVKKIHE NEKRLEAGDH PVELLARDFE KNYNMYIFPV HWQFGQLDQH 180
  181 PIDGYLSHTE LAPLRAPLIP MEHCTTRFFE TCDLDNDKYI ALDEWAGCFG IKQKDIDKDL 240
  241 VI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.69897
Match: 1bmoA
Description: C-terminal (EC) domain of BM-40/SPARC/osteonectin; Domain of BM-40/SPARC/osteonectin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.60755835611133 bayes_pls_golite062009
growth factor activity 3.99369234248402 bayes_pls_golite062009
epidermal growth factor receptor binding 3.33042410578504 bayes_pls_golite062009
glycosaminoglycan binding 2.86713236325679 bayes_pls_golite062009
heparin binding 2.49012176521764 bayes_pls_golite062009
extracellular matrix structural constituent 2.05269657997842 bayes_pls_golite062009
ErbB-2 class receptor binding 2.03157496298046 bayes_pls_golite062009
binding 1.9180887037845 bayes_pls_golite062009
peptidase inhibitor activity 1.53810598398471 bayes_pls_golite062009
endopeptidase inhibitor activity 1.36634831540772 bayes_pls_golite062009
transcription regulator activity 1.32276701662595 bayes_pls_golite062009
polysaccharide binding 1.29357847772022 bayes_pls_golite062009
pattern binding 1.26957983931218 bayes_pls_golite062009
serine-type endopeptidase inhibitor activity 1.23661226950215 bayes_pls_golite062009
ErbB-3 class receptor binding 1.17748426017837 bayes_pls_golite062009
transcription factor binding 1.12166879177902 bayes_pls_golite062009
transcription cofactor activity 0.99108904558314 bayes_pls_golite062009
protein binding 0.583752463668114 bayes_pls_golite062009
cytoskeletal protein binding 0.37583220367244 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009
calcium-dependent protein binding 0.22929572509808 bayes_pls_golite062009
enzyme inhibitor activity 0.204626400011227 bayes_pls_golite062009
structural constituent of muscle 0.14454341648094 bayes_pls_golite062009
nucleic acid binding 0.0981928858355918 bayes_pls_golite062009
DNA binding 0.0960817636106102 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle