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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL43B, RPL43A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • metal ion binding
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 2.6013E-26 20 101 16 6292
    cytosolic part 6.6126E-25 20 122 16 6292
    ribosomal subunit 5.9557E-22 20 183 16 6292
    cytosolic large ribosomal subunit 2.0942E-20 20 60 12 6292
    cytosol 8.0884E-19 20 284 16 6292
    ribosome 1.1362E-18 20 290 16 6292
    ribonucleoprotein complex 3.2365E-18 20 514 18 6292
    large ribosomal subunit 4.9601E-17 20 110 12 6292
    non-membrane-bounded organelle 2.0079E-10 20 959 16 6292
    intracellular non-membrane-bounded organelle 2.0079E-10 20 959 16 6292
    macromolecular complex 2.9554E-9 20 1635 18 6292
    cytosolic small ribosomal subunit 5.1144E-6 20 38 4 6292
    small ribosomal subunit 7.0211E-5 20 73 4 6292
    organelle part 8.0178E-5 20 2282 16 6292
    intracellular organelle part 8.0178E-5 20 2282 16 6292
    preribosome 1.5437E-4 20 34 3 6292
    cytoplasmic part 2.5683E-4 20 2482 16 6292
    90S preribosome 1.2688E-3 20 17 2 6292
    stress granule 3.1786E-3 20 1 1 6292
    cytoplasm 6.983E-3 20 3552 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 6.9097E-23 20 376 19 6292
    cellular macromolecule biosynthetic process 2.8607E-15 20 1187 20 6292
    macromolecule biosynthetic process 2.9594E-15 20 1189 20 6292
    gene expression 1.3717E-14 20 1283 20 6292
    cellular protein metabolic process 3.8001E-14 20 1074 19 6292
    protein metabolic process 1.1011E-13 20 1136 19 6292
    cellular biosynthetic process 7.6887E-13 20 1567 20 6292
    biosynthetic process 1.1992E-12 20 1602 20 6292
    cellular macromolecule metabolic process 1.5096E-9 20 2285 20 6292
    macromolecule metabolic process 2.629E-9 20 2349 20 6292
    primary metabolic process 1.757E-7 20 2896 20 6292
    cellular metabolic process 4.4416E-7 20 3033 20 6292
    ribosomal subunit assembly 5.9497E-7 20 55 5 6292
    metabolic process 9.9232E-7 20 3157 20 6292
    ribosome assembly 1.2808E-6 20 64 5 6292
    organelle assembly 1.8691E-6 20 69 5 6292
    ribonucleoprotein complex assembly 7.8106E-6 20 92 5 6292
    ribosomal small subunit biogenesis 6.8171E-5 20 26 3 6292
    cellular macromolecular complex assembly 2.0867E-4 20 182 5 6292
    ribosomal large subunit assembly 2.7112E-4 20 41 3 6292
    ribosome biogenesis 5.3131E-4 20 346 6 6292
    ribonucleoprotein complex biogenesis 8.0445E-4 20 374 6 6292
    ribosomal small subunit assembly 8.5383E-4 20 14 2 6292
    cellular process 8.6878E-4 20 4426 20 6292
    ribosomal large subunit biogenesis 1.0582E-3 20 65 3 6292
    cellular macromolecular complex subunit organization 1.0596E-3 20 259 5 6292
    macromolecular complex assembly 1.5279E-3 20 281 5 6292
    response to cycloalkane 3.1786E-3 20 1 1 6292
    response to organic cyclic substance 3.1786E-3 20 1 1 6292
    response to cycloheximide 3.1786E-3 20 1 1 6292
    macromolecular complex subunit organization 4.3653E-3 20 357 5 6292
    cellular component assembly 6.0258E-3 20 385 5 6292
    response to antibiotic 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 9.1705E-28 20 212 19 6292
    structural molecule activity 9.2239E-24 20 339 19 6292
    RNA binding 7.2769E-4 20 367 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle