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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.558E-14 11 211 10 6292
    nuclear lumen 3.5105E-11 11 453 10 6292
    non-membrane-bounded organelle 9.8204E-10 11 959 11 6292
    intracellular non-membrane-bounded organelle 9.8204E-10 11 959 11 6292
    organelle lumen 1.5115E-9 11 660 10 6292
    intracellular organelle lumen 1.5115E-9 11 660 10 6292
    membrane-enclosed lumen 2.7156E-9 11 700 10 6292
    nuclear part 2.4537E-7 11 1103 10 6292
    preribosome, large subunit precursor 3.321E-7 11 9 3 6292
    Noc1p-Noc2p complex 2.779E-6 11 2 2 6292
    nucleus 4.1084E-6 11 2041 11 6292
    preribosome 2.31E-5 11 34 3 6292
    Noc complex 2.771E-5 11 5 2 6292
    intracellular organelle part 2.8711E-4 11 2282 10 6292
    organelle part 2.8711E-4 11 2282 10 6292
    90S preribosome 3.7257E-4 11 17 2 6292
    nucleolar part 2.6406E-3 11 45 2 6292
    Noc2p-Noc3p complex 3.4937E-3 11 2 1 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    nuclear envelope 4.2616E-3 11 199 3 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292
    ribonucleoprotein complex 9.1283E-3 11 514 4 6292
    nuclear outer membrane 9.3747E-3 11 86 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.1946E-14 11 346 11 6292
    ribonucleoprotein complex biogenesis 2.846E-14 11 374 11 6292
    cellular component biogenesis 2.7383E-11 11 694 11 6292
    ribosomal large subunit biogenesis 4.263E-10 11 65 6 6292
    ribosome assembly 4.0957E-8 11 64 5 6292
    organelle assembly 6.0129E-8 11 69 5 6292
    ribonucleoprotein complex assembly 2.583E-7 11 92 5 6292
    ribosomal large subunit assembly 4.9559E-7 11 41 4 6292
    ribosomal subunit assembly 1.6483E-6 11 55 4 6292
    cellular macromolecular complex assembly 7.6897E-6 11 182 5 6292
    cellular macromolecular complex subunit organization 4.2853E-5 11 259 5 6292
    macromolecular complex assembly 6.3461E-5 11 281 5 6292
    macromolecular complex subunit organization 1.988E-4 11 357 5 6292
    cellular component assembly 2.8391E-4 11 385 5 6292
    establishment of ribosome localization 8.8271E-4 11 26 2 6292
    ribosome localization 8.8271E-4 11 26 2 6292
    ribosomal subunit export from nucleus 8.8271E-4 11 26 2 6292
    rRNA processing 1.2042E-3 11 128 3 6292
    rRNA metabolic process 1.466E-3 11 137 3 6292
    establishment of organelle localization 3.9232E-3 11 55 2 6292
    ncRNA processing 5.2979E-3 11 215 3 6292
    ncRNA metabolic process 8.7081E-3 11 257 3 6292
    regulation of transcription, mating-type specific 8.7135E-3 11 5 1 6292
    organelle localization 9.1655E-3 11 85 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    5S rRNA binding 2.779E-6 11 2 2 6292
    rRNA binding 3.2905E-4 11 16 2 6292
    ATP-dependent RNA helicase activity 1.0247E-3 11 28 2 6292
    RNA-dependent ATPase activity 1.0996E-3 11 29 2 6292
    7S RNA binding 1.7483E-3 11 1 1 6292
    RNA helicase activity 2.3031E-3 11 42 2 6292
    RNA binding 2.7066E-3 11 367 4 6292
    ATP-dependent helicase activity 3E-3 11 48 2 6292
    purine NTP-dependent helicase activity 3E-3 11 48 2 6292
    rRNA primary transcript binding 8.7135E-3 11 5 1 6292
    helicase activity 8.7534E-3 11 83 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle